Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

1993 • 3,080 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis

1994 • 2,067 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Progressive Supranuclear Palsy

1964 • 1,864 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Age-related changes in oxidized proteins.

1987 • 1,229 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

1994 • 1,120 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

1989 • 1,117 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

1984 • 1,005 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

1996 • 976 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

1997 • 866 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

1997 • 792 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy

1999 • 775 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Mitochondrial defect in Huntington's disease caudate nucleus

1996 • 737 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 • 718 citations

Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency

1995 • 711 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

Superoxide Dismutase Activity, Oxidative Damage, and Mitochondrial Energy Metabolism in Familial and Sporadic Amyotrophic Lateral Sclerosis

1993 • 627 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

1994 • 604 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1997 • 593 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

1992 • 575 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

1999 • 546 citations

Brain Cytochrome Oxidase in Alzheimer's Disease

1992 • 526 citations

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

1994 • 502 citations

Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease

1998 • 497 citations

Electron transport chain defects in Alzheimer's disease brain

1994 • 483 citations

Nitric oxide, mitochondria and neurological disease

1999 • 474 citations

Evidence for irnnairment of energy metabofism in vivo in Huntington's disease using localized 1H NMR spectroscopy

1993 • 471 citations

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

1994 • 462 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle

1999 • 450 citations

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

1992 • 450 citations

A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra

1989 • 445 citations

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

1994 • 420 citations

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

1994 • 420 citations

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1992 • 416 citations

Energy metabolism defects in Huntington's disease and effects of coenzyme Q₁₀

1997 • 407 citations

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

1988 • 406 citations

Genetic evidence for the involvement of τ in progressive supranuclear palsy

1997 • 387 citations

Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1998 • 382 citations

Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease

1992 • 367 citations

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

1992 • 362 citations

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1983 • 355 citations

Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice

1995 • 353 citations

Expression of heme oxygenase‐1 in the senescent and alzheimer‐diseased brain

1995 • 352 citations

RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

1997 • 345 citations

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

1992 • 329 citations

Oxidative damage to protein in sporadic motor neuron disease spinal cord

1995 • 326 citations

Decline with age of the respiratory chain activity in human skeletal muscle

1994 • 325 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

Mitochondrial enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death

1999 • 324 citations

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

1994 • 316 citations

Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease

1996 • 313 citations

Glutathione peroxidase activity in Parkinson's disease brain

1985 • 301 citations

Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophc lateral sclerosis

1996 • 300 citations

Neurofibrillary Degeneration in Progressive Supranuclear Palsy and Corticobasal Degeneration

1999 • 284 citations

Neurodegenerative disorders with extensive tau pathology: A comparative study and review

1996 • 280 citations

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease

1991 • 269 citations

Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia

1991 • 265 citations

Iron deposits in multiple sclerosis and Alzheimer's disease brains

1997 • 262 citations

Cybrids in Alzheimer's disease: A cellular model of the disease?

1998 • 260 citations

Decreased Ferritin Levels in Brain in Parkinson's Disease

1990 • 254 citations

Calcium Homeostasis and Reactive Oxygen Species Production in Cells Transformed by Mitochondria from Individuals with Sporadic Alzheimer’s Disease

1997 • 253 citations

Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing

1994 • 253 citations

Presence of 4‐hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

1998 • 249 citations

Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis

1998 • 249 citations

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease

1997 • 245 citations

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

1990 • 243 citations

Cytochrome c Oxidase subunit I microdeletion in a patient with motor neuron disease

1998 • 241 citations

Oxygen toxicity protecting enzymes in Parkinson's disease

1988 • 239 citations

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1992 • 237 citations

¹ H NMR spectroscopy studies of Huntington's disease

1998 • 235 citations

Altered cerebral energy metabolism in Alzheimer's disease: a PET study.

1994 • 229 citations

SUBCORTICAL DEMENTIA

1985 • 228 citations

Increased Cerebral Glucose‐6‐Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress

1986 • 226 citations

Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease

1991 • 224 citations

Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease

1995 • 224 citations

Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca²⁺ concentration in transfected neuroblastoma SH‐SY5Y cells

1997 • 221 citations

Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle

1999 • 215 citations

Induction of Heme Oxygenase‐1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease

1995 • 209 citations

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

1994 • 203 citations

Positron Emission Tomography Study in Progressive Supranuclear Palsy

1990 • 199 citations

Evidence of an oxidative challenge in the Alzheimer's brain

1994 • 194 citations

Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's disease

1992 • 192 citations

An immunohistochemical study on ?-ketoglutarate dehydrogenase complex in Parkinson's disease

1994 • 192 citations

Biochemical abnormalities in Huntington's chorea brains

1974 • 185 citations

Mitochondria in Sporadic Amyotrophic Lateral Sclerosis

1998 • 179 citations

Brain α‐Ketoglutarate Dehydrotenase Complex Activity in Alzheimer's Disease

1993 • 174 citations

4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau

1997 • 173 citations

Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy

1994 • 170 citations

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

1995 • 168 citations

Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease

1994 • 166 citations

Cerebral hypometabolism in progressive supranuclear palsy studied with positron emission tomography

1988 • 164 citations

Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

1990 • 160 citations

Lowered cerebral glucose utilization in amyotrophic lateral sclerosis

1987 • 158 citations

In vivo ³¹ P NMR profiles of Alzheimer's disease and multiple subcortical infarct dementia

1989 • 156 citations

Altered Calcium Homeostasis in Cells Transformed by Mitochondria from Individuals with Parkinson's Disease

1997 • 151 citations

Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus.

1995 • 150 citations

Amyotrophic lateral sclerosis

1996 • 140 citations

STEELE-RICHARDSON-OLSZEWSKI SYNDROME

1988 • 139 citations

Metabolic Dysfunction in Familial, but Not Sporadic, Amyotrophic Lateral Sclerosis

1998 • 136 citations

Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys

1994 • 133 citations

Hepatic Ultrastructural Changes and Liver Dysfunction in Amyotrophic Lateral Sclerosis

1987 • 133 citations

Decreased cytochrome c oxidase activity but unchanged superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis

1996 • 133 citations

Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and γ-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases

1985 • 131 citations

Positron tomography demonstrates frontal lobe hypometabolism in progressive supranuclear palsy

1989 • 128 citations

Mitochondria1 respiratory chain activity in skeletal muscle from patients with Parkinson's disease

1993 • 127 citations

Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q ₁₀ in parkinsonian patients

1998 • 112 citations

Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts

1991 • 110 citations

Cortical Motor-Sensory Hypometabolism in Amyotrophic Lateral Sclerosis

1988 • 109 citations

Frontal Lobe Dysfunction in Progressive Supranuclear Palsy

2000 • 106 citations

Respiratory chain and mitochondrial DNA in muscle and brain in Parkinson's disease patients

1993 • 98 citations

Association between Alzheimer's disease and theNOS3 gene

1999 • 98 citations

The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease.

1999 • 97 citations

Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatum

1998 • 95 citations

Brain membrane fluidity and lipid peroxidation in Alzheimer's disease

1990 • 95 citations

Decreased N-acetyl-aspartate/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: a proton magnetic resonance spectroscopy study.

1997 • 94 citations

Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria

1994 • 89 citations

Abnormal Substrate Levels That Depend upon Mitochondrial Function in Cerebrospinal Fluid from Alzheimer Patients

1998 • 86 citations

Glutamate uptake by astrocytes is inhibited by reactive oxygen intermediates but not by other macrophage-derived molecules including cytokines, leukotrienes or platelet-activating factor

1993 • 85 citations

Mitochondrial DNA 4977 bp deletion and OH ⁸ dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients

1999 • 74 citations

Increased sensitivity of fibroblasts from amyotrophic lateral sclerosis patients to oxidative stress

1998 • 71 citations

Mitochondria from Alzheimer's fibroblasts show decreased uptake of calcium and increased sensitivity to free radicals

1994 • 69 citations

Oxygen Free Radicals and Tissue Injury

1993 • 68 citations

Evidence for Oxidative Stress in the Subthalamic Nucleus in Progressive Supranuclear Palsy

1999 • 67 citations

Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia

1995 • 67 citations

Brain Energy Metabolism, Cognitive Function and Down-regulated Oxidative Phosphorylation in Alzheimer Disease

1996 • 65 citations

Functional and morphometric study of the liver in motor neuron disease

1985 • 64 citations

Identification of a novel polymorphism in the promoter region of the tau gene highly associated to progressive supranuclear palsy in humans

1999 • 62 citations

Calcium stores in cultured fibroblasts and their changes with Alzheimer's disease

1996 • 62 citations

Regional Brain Activity of Free Radical Defense Enzymes in Autopsy Samples from Patients with Alzheimer's Disease and from Nondemented Controls

1994 • 60 citations

Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, normal aged and Alzheimer donors

1991 • 58 citations

Oxidative damage in Alzheimer’s disease

2015 • 56 citations

Serum antioxidant enzyme activity in Parkinson's disease

1992 • 51 citations

Increased mitochondrial superoxide dismutase activity in Parkinson's disease but not amyotrophic lateral sclerosis motor cortex

1997 • 47 citations

Cerebral perfusion in progressive supranuclear palsy.

1992 • 47 citations

Subcortical damage and cortical dysfunction in progressive supranuclear palsy demonstrated by positron emission tomography

1992 • 45 citations

Role of protein oxidation in aging and in age-associated neurodegenerative diseases

1994 • 44 citations

Inhibition of α-Ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1995 • 43 citations

Rapid Communication Muscle Mitochondrial ATP Production in Progressive Supranuclear Palsy

1994 • 40 citations

Association between the gene encoding the E2 subunit of the α‐ketoglutarate dehydrogenase complex and Parkinson's disease

1998 • 39 citations

No evidence for altered muscle mitochondrial function in Parkinson's disease.

1993 • 38 citations

Isolation of a cytochrome oxidase gene overexpressed in Alzheimer's disease brain

1992 • 14 citations

Parkinsonism Treatment: Part III—Update

1992 • 8 citations