Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Mitochondrial DNA Mutation Associated with Leber's Hereditary Optic Neuropathy

1988 • 2,368 citations

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Mitochondrial DNA Deletions in Progressive External Ophthalmoplegia and Kearns-Sayre Syndrome

1989 • 1,009 citations

A practical guide to molecular cloning

1987 • 360 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

Cytochrome-c-oxidase deficient cardiomyocytes in the human heart--an age-related phenomenon. A histochemical ultracytochemical study.

1989 • 275 citations

Alterations in cardiovascular structure and function with advancing age

1986 • 194 citations

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging

1988 • 189 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1990 • 188 citations

Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy

1990 • 174 citations

Maternal inheritance of deleted mitochondrial DNA in a family with mitochondrial myopathy

1988 • 137 citations

A common mitochondrial DNA mutation in the t-RNA(Lys) of patients with myoclonus epilepsy associated with ragged-red fibers.

1990 • 105 citations

Age-related changes in left ventricular diastolic performance

1986 • 101 citations

Cardiac Muscle Changes in Senescence

1987 • 83 citations

Multiple populations of deleted mitochondrial DNA detected by a novel gene amplification method

1989 • 60 citations

The epidemiology of cardiac failure

1965 • 57 citations

Direct sequencing of deleted mitochondrial DNA in myopathic patients

1989 • 51 citations

Small, beautiful and essential

1989 • 46 citations

Deleted Work

1955 • 0 citations