Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, normal aged and Alzheimer donors

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

1986 • 775 citations

Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels

1987 • 529 citations

Calcium and the aging nervous system

1987 • 384 citations

Decreased levels of protein kinase C in Alzheimer brain

1988 • 242 citations

Reduced Phosphoinositide Concentrations in Anterior Temporal Cortex of Alzheimer‐Diseased Brains

1987 • 201 citations

Differential involvement of protein kinase C isozymes in Alzheimer's disease

1990 • 168 citations

Metabolism of <scp>d</scp>-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate

1987 • 147 citations

Age-related defect in signal transduction during lectin activation of murine T lymphocytes.

1987 • 147 citations

Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors.

1986 • 135 citations

Reduced Protein Kinase C Immunoreactivity and Altered Protein Phosphorylation in Alzheimer's Disease Fibroblasts

1989 • 100 citations

Effect of Age on Brain Cortical Protein Kinase C and Its Mediation of 5‐Hydroxytryptamine Release

1989 • 93 citations

Platelet activity and phosphoinositide turnover increase with advancing age

1990 • 80 citations

Altered response of fibroblasts from aged and Alzheimer donors to drugs that elevate cytosolic free calcium

1988 • 73 citations

Down-regulation of protein kinase C potentiates angiotensin II-stimulated polyphosphoinositide hydrolysis in vascular smooth-muscle cells

1989 • 69 citations

Concentrations and disappearance post mortem of polyphosphoinositides in developing rat brain

1967 • 57 citations

Free and total lipid myo-inositol concentrations decrease with age in human brain

1983 • 42 citations

Age-related impairment in rat parotid cell α1-adrenergic action at the level of inositol trisphosphate responsiveness

1988 • 41 citations

Decreased efficacy of inositol 1,4,5-trisphosphate to elicit calcium mobilization from cerebrocortical microsomes of aged rats.

1990 • 39 citations

Control of platelet protein kinase C activation by cyclic AMP

1988 • 29 citations

Turnover of inositol phosphates in brain during ischemia-induced breakdown of polyphosphoinositides

1988 • 26 citations

Cultured Cells as a Screen for Novel Treatments of Alzheimer's Disease

1989 • 17 citations

Interactions between inositol phosphates and cytosolic free calcium following bradykinin stimulation in cultured human skin fibroblasts

1991 • 17 citations

Activators of protein kinase C enhance cyclic AMP accumulation in cerebral cortical and diencephalic neurons in primary culture

1988 • 6 citations

Abnormal calcium homeostasis in platelets isolated from Alzheimer's disease patients

1990 • 1 citations