Mitochondrial DNA 4977 bp deletion and OH ⁸ dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients

Sequence and organization of the human mitochondrial genome

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Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

1997 • 1,108 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Oxidative Decay of DNA

1997 • 938 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

1998 • 694 citations

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1993 • 583 citations

A Direct Repeat Is a Hotspot for Large-Scale Deletion of Human Mitochondrial DNA

1989 • 566 citations

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

1997 • 526 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1992 • 416 citations

Marked Changes in Mitochondrial DNA Deletion Levels in Alzheimer Brains

1994 • 307 citations

Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system

1995 • 284 citations

Oxidative stress and mitochondrial dysfunction in neurodegeneration

1996 • 176 citations

Decreased Cytochrome-c Oxidase Activity and Lack of Age-Related Accumulation of Mitochondrial DNA Deletions in the Brains of Schizophrenics

1995 • 153 citations

Artifacts associated with the measurement of oxidized DNA bases.

1997 • 138 citations

Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine

1991 • 131 citations

Increased Oxidative Damage to Mitochondrial DNA Following Chronic Ethanol Consumption

1997 • 124 citations

Action of Mitochondrial DNA Polymerase γ at Sites of Base Loss or Oxidative Damage

1995 • 123 citations

Correlation Between Mitochondrial DNA 4977-bp Deletion and Respiratory Chain Enzyme Activities in Aging Human Skeletal Muscles

1994 • 115 citations

Artifacts Associated with the Measurement of Oxidized DNA Bases

1997 • 100 citations

Molecular aspects of aging

1996 • 90 citations

[38] Detection and quantification of oxidative adducts of mitochondrial DNA

1996 • 75 citations

Methods in Aging Research

1998 • 74 citations

Identification by in Organello Footprinting of Protein Contact Sites and of Single-stranded DNA Sequences in the Regulatory Region of Rat Mitochondrial DNA

1995 • 34 citations

Mitochondrial cardiomyopathy

1995 • 24 citations

Paucity of deleted mitochondrial DNAs in brain regions of Huntington's disease patients

1995 • 16 citations

Mitochondrial DNA Deletions

1998 • 11 citations