Appetite control

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Central nervous system control of food intake

2000 • 6,305 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

The hormone resistin links obesity to diabetes

2001 • 4,720 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1995 • 3,159 citations

Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients

2000 • 3,142 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

2001 • 2,534 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Gut hormone PYY3-36 physiologically inhibits food intake

2002 • 2,263 citations

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

1996 • 2,229 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

2002 • 2,081 citations

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

1999 • 1,959 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

A role for glucagon-like peptide-1 in the central regulation of feeding

1996 • 1,880 citations

GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN

1987 • 1,845 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

2004 • 1,610 citations

Leptin-regulated endocannabinoids are involved in maintaining food intake

2001 • 1,557 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Cholecystokinin decreases food intake in rats.

1973 • 1,454 citations

Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat

1978 • 1,344 citations

Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans

1997 • 1,299 citations

Hypothalamic CART is a new anorectic peptide regulated by leptin

1998 • 1,283 citations

The stomach is a source of leptin

1998 • 1,215 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

A leptin missense mutation associated with hypogonadism and morbid obesity

1998 • 1,187 citations

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

1999 • 1,182 citations

Positional cloning of the mouse obese gene and its human homologue

1995 • 1,164 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

1998 • 1,136 citations

Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation

2002 • 1,132 citations

Ghrelin Causes Hyperphagia and Obesity in Rats

2001 • 1,121 citations

Transient increase in obese gene expression after food intake or insulin administration

1995 • 1,102 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

2001 • 1,091 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

1993 • 1,064 citations

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1994 • 1,055 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

2004 • 895 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight

1999 • 862 citations

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

2001 • 862 citations

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

2003 • 858 citations

Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity

1986 • 856 citations

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

1998 • 802 citations

Adiponectin acts in the brain to decrease body weight

2004 • 797 citations

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

1998 • 797 citations

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

2000 • 795 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

1998 • 753 citations

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

1997 • 750 citations

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

1988 • 743 citations

Brainstem projections of sensory and motor components of the vagus nerve in the rat

1982 • 741 citations

Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction.

1985 • 733 citations

Two brain cholecystokinin receptors: implications for behavioral actions

1986 • 719 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

1994 • 703 citations

Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

2004 • 699 citations

Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa

2001 • 695 citations

Post-prandial decrease of circulating human ghrelin levels

2001 • 691 citations

Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

1991 • 678 citations

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

1997 • 670 citations

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

1967 • 664 citations

Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus

1985 • 661 citations

Ghrelin Enhances Appetite and Increases Food Intake in Humans

2001 • 634 citations

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

2004 • 632 citations

Deletion of Ghrelin Impairs neither Growth nor Appetite

2003 • 631 citations

C-terminal octapeptide of cholecystokinin decreases food intake in man

1981 • 596 citations

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

1995 • 573 citations

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

2002 • 573 citations

Glucagon-Like Peptide-1 and Glucose-Dependent Insulin-Releasing Polypeptide Plasma Levels in Response to Nutrients

1995 • 572 citations

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

2002 • 547 citations

The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

2002 • 530 citations

An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat

1985 • 523 citations

Unraveling the central nervous system pathways underlying responses to leptin

1998 • 520 citations

Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood

1976 • 510 citations

Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist

2002 • 509 citations

Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

1999 • 502 citations

Weight loss increases circulating levels of ghrelin in human obesity

2002 • 498 citations

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

2004 • 496 citations

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

2004 • 489 citations

Activation of Central Melanocortin Pathways by Fenfluramine

2002 • 481 citations

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

1993 • 479 citations

Pancreatic Polypeptide Reduces Appetite and Food Intake in Humans

2003 • 475 citations

Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus

1996 • 473 citations

The source of cerebral insulin

2004 • 473 citations

Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

2003 • 458 citations

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

2000 • 454 citations

Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men.

1999 • 454 citations

Interactions of Glucagon-Like Peptide-1 (GLP-1) with the Blood-Brain Barrier

2002 • 452 citations

Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression.

1992 • 444 citations

Localization of insulin receptor mRNA in rat brain by in situ hybridization

1990 • 442 citations

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

1999 • 438 citations

Tissue‐specific expression of the human receptor for glucagon‐like peptide‐I: brain, heart and pancreatic forms have the same deduced amino acid sequences

1995 • 425 citations

The role of postprandial releases of insulin and incretin hormones in meal-induced satiety—effect of obesity and weight reduction

2001 • 421 citations

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

2002 • 421 citations

Role of the Y5 neuropeptide Y receptor in feeding and obesity

1998 • 419 citations

Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism

1991 • 414 citations

Modulation of Brain Reward Circuitry by Leptin

2000 • 411 citations

The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

2002 • 406 citations

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

2001 • 403 citations

Partial leptin deficiency and human adiposity

2001 • 402 citations

The lateral hypothalamic area revisited: Ingestive behavior

1996 • 400 citations

Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas.

1992 • 398 citations

The Neuroanatomical Axis for Control of Energy Balance

2002 • 390 citations

Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion

1985 • 386 citations

CART peptides in the central control of feeding and interactions with neuropeptide Y

1998 • 379 citations

Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain

2001 • 378 citations

Attenuated GLP-1 secretion in obesity: cause or consequence?

1996 • 374 citations

Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats

1984 • 372 citations

The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity

2001 • 371 citations

Characterization of the effects of pancreatic polypeptide in the regulation of energy balance

2003 • 349 citations

Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice

2001 • 345 citations

Peripheral ghrelin selectively increases Fos expression in neuropeptide Y – synthesizing neurons in mouse hypothalamic arcuate nucleus

2002 • 330 citations

Orexin Synthesis and Response in the Gut

1999 • 329 citations

The multifunctional or moonlighting protein CD26/DPPIV

2003 • 328 citations

Impaired transport of leptin across the blood-brain barrier in obesity☆

1999 • 328 citations

Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract

2002 • 318 citations

Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade

2000 • 318 citations

Insulin and the Blood-Brain Barrier

2003 • 314 citations

Increased Hypothalamic Content of Preproneuropeptide Y Messenger Ribonucleic Acid in Genetically Obese Zucker Rats and Its Regulation by Food Deprivation*

1990 • 312 citations

Evidence of a Functional Relationship between the Nucleus Accumbens Shell and Lateral Hypothalamus Subserving the Control of Feeding Behavior

1999 • 310 citations

Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat

1999 • 309 citations

A Meta-Analysis of the Effect of Glucagon-Like Peptide-1 (7-36) Amide on Ad Libitum Energy Intake in Humans

2001 • 304 citations

Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

2001 • 295 citations

Subtypes Y1 and Y2 of the Neuropeptide Y Receptor Are Respectively Expressed in Pro-Opiomelanocortin- and Neuropeptide-Y-Containing Neurons of the Rat Hypothalamic Arcuate Nucleus

1997 • 294 citations

Ascending projections from the solitary tract nucleus to the hypothalamus. A Phaseolus vulgaris lectin tracing study in the rat

1989 • 293 citations

Ghrelin Modulates the Downstream Molecules of Insulin Signaling in Hepatoma Cells

2002 • 292 citations

Taste responses and preferences for sweet high-fat foods: Evidence for opioid involvement☆

1992 • 290 citations

Behavioral characterization of neuropeptide Y knockout mice

2000 • 287 citations

Neuronal localisation of neuropeptide Y gene expression in rat brain

1989 • 285 citations

Glucagon-Like Peptide-1-Responsive Catecholamine Neurons in the Area Postrema Link Peripheral Glucagon-Like Peptide-1 with Central Autonomic Control Sites

2003 • 282 citations

GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans

1999 • 277 citations

Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor

1999 • 276 citations

Long-term Follow-up of Patients' Status after Gastric Bypass

2001 • 274 citations

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

1999 • 274 citations

Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats

1991 • 274 citations

Disordered food intake and obesity in rats lacking cholecystokinin A receptors

1998 • 273 citations

Nucleus accumbens opioid, GABAergic, and dopaminergic modulation of palatable food motivation: Contrasting effects revealed by a progressive ratio study in the rat.

2003 • 266 citations

Reduced central leptin sensitivity in rats with diet-induced obesity

2002 • 266 citations

Enhanced intake of high-fat food following striatal mu-opioid stimulation: microinjection mapping and Fos expression

2000 • 258 citations

The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin

2000 • 257 citations

Distribution of pancreatic polypeptide and peptide YY

2002 • 254 citations

Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents

1998 • 254 citations

The Central Melanocortin System and the Integration of Short- and Long-term Regulators of Energy Homeostasis

2004 • 254 citations

The perifornical area: the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s)

1993 • 250 citations

Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat

1991 • 246 citations

Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats

2002 • 245 citations

Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice

2002 • 245 citations

Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype

2003 • 237 citations

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

1996 • 232 citations

Leptin and Insulin Action in the Central Nervous System

2002 • 231 citations

Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats

1986 • 230 citations

Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin

1997 • 221 citations

Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice

1998 • 217 citations

Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight

1999 • 215 citations

Effects of PYY[3–36] in rodent models of diabetes and obesity

2004 • 213 citations

Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans

2001 • 212 citations

Neuropeptide Y: Direct and indirect action on insulin secretion in the rat

1985 • 211 citations

Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity

2002 • 210 citations

Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.

2000 • 209 citations

Conformational flexibility in a small globular hormone: X‐ray analysis of avian pancreatic polypeptide at 0.98‐Å resolution

1983 • 208 citations

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus

1997 • 206 citations

Central connections of the sensory and motor nuclei of the vagus nerve

1983 • 206 citations

Brain Stem Is a Direct Target for Leptin’s Action in the Central Nervous System

2002 • 202 citations

Neuropeptide Y feeding receptors: are multiple subtypes involved?

1999 • 200 citations

Stimulation of Gastric Acid Secretion by Centrally Administered Orexin-A in Conscious Rats

1999 • 199 citations

Neuropeptide Y-Mediated Inhibition of Proopiomelanocortin Neurons in the Arcuate Nucleus Shows Enhanced Desensitization in ob/ob Mice

2004 • 197 citations

Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity

1997 • 197 citations

Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines

2004 • 196 citations

Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y

1999 • 195 citations

Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells

1975 • 194 citations

Role of Ghrelin Polymorphisms in Obesity Based on Three Different Studies

2002 • 189 citations

Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

2001 • 187 citations

Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands

1998 • 186 citations

Metabolic hormones and regulation of body weight.

1974 • 185 citations

Generation of Soluble Leptin Receptor by Ectodomain Shedding of Membrane-spanning Receptors in Vitro and in Vivo

2002 • 185 citations

Cholecystokinin and leptin act synergistically to reduce body weight

2000 • 185 citations

Central and peripheral vagal transport of cholecystokinin binding sites occurs in afferent fibers

1990 • 182 citations

Increased Hypothalamic Content of Preproneuropeptide-Y Messenger Ribonucleic Acid in Streptozotocin-Diabetic Rats*

1990 • 180 citations

A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences

2000 • 178 citations

Brain regions where cholecystokinin suppresses feeding in rats

2000 • 174 citations

Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain

1996 • 173 citations

Insulin in the brain: a hormonal regulator of energy balance

1992 • 167 citations

Molecular Forms of Human Enteroglucagon in Tissue and Plasma: Plasma Responses to Nutrient Stimuli in Health and in Disorders of the Upper Gastrointestinal Tract*

1983 • 165 citations

Metering of intravenous versus oral nutrients and regulation of energy balance

1976 • 165 citations

The cholecystokinin receptor antagonist L364,718 increases food intake in the rat by attenuation of the action of endogenous cholecystokinin

1988 • 163 citations

Cholecystokinin and stomach distension combine to reduce food intake in humans

2003 • 163 citations

A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

1998 • 163 citations

Gut hormone changes after jejunoileal (JIB) or biliopancreatic (BPB) bypass surgery for morbid obesity.

1981 • 160 citations

Ghrelin, A Novel Placental-Derived Hormone

2001 • 158 citations

Increased feeding in response to bilateral injection of insulin antibodies in the VMH

1977 • 157 citations

Pancreatic polypeptide: A possible role in the regulation of food intake in the mouse. Hypothesis

1977 • 154 citations

Ghrelin Stimulates GH But Not Food Intake in Arcuate Nucleus Ablated Rats

2002 • 153 citations

Effects of Chronic Central Nervous System Administration of Agouti-Related Protein in Pair-Fed Animals

2001 • 152 citations

A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats

2001 • 151 citations

Diverse functions of neuropeptide Y revealed using genetically modified animals

2002 • 150 citations

Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers

2002 • 146 citations

Ghrelin Receptor Gene: Identification of Several Sequence Variants in Extremely Obese Children and Adolescents, Healthy Normal-Weight and Underweight Students, and Children with Short Normal Stature

2004 • 146 citations

Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity

1993 • 145 citations

Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding.

1999 • 144 citations

Opioid receptor involvement in the effect of AgRP- (83–132) on food intake and food selection

2001 • 144 citations

Pancreatic polypeptide infusions reduce food intake in Prader-Willi syndrome

1993 • 141 citations

Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain

1990 • 139 citations

The Organization and Biochemical Specificity of Afferent Projections to the Paraventricular and Supraoptic Nuclei

1983 • 137 citations

Influence of meal composition on postprandial peripheral plasma concentrations of vasoactive peptides in man

1996 • 137 citations

A new molecular form of PYY: Structural characterization of human PYY(3–36) and PYY(1–36)

1989 • 136 citations

Roles of pancreatic polypeptide in regulation of food intake

2002 • 135 citations

Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat

1992 • 134 citations

Agouti-Related Protein (AGRP) Has a Central Inhibitory Action on the Hypothalamic-Pituitary-Thyroid (HPT) Axis; Comparisons between the Effect of AGRP and Neuropeptide Y on Energy Homeostasis and the HPT Axis

2002 • 134 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 134 citations

Acute orexin effects on insulin secretion in the rat: in vivo and in vitro studies

1999 • 134 citations

Selective reward deficit in mice lacking beta-endorphin and enkephalin.

2002 • 131 citations

Glucagon-like Peptide 1 (GLP-1): An Intestinal Hormone, Signalling Nutritional Abundance, with an Unusual Therapeutic Potential

1999 • 129 citations

Suppression of food intake by intravenous nutrients and insulin in the baboon

1984 • 128 citations

Effect of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246 on neuropeptide Y release

2000 • 124 citations

Evidence of altered hypothalamic pro-opiomelanocortin/ neuropeptide Y mRNA expression in tubby mice

1998 • 124 citations

A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep

2002 • 123 citations

Food Fails to Suppress Ghrelin Levels in Obese Humans

2002 • 122 citations

Abdominal vagal mediation of the satiety effects of CCK in rats

2004 • 121 citations

Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues

1999 • 118 citations

Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression

1995 • 115 citations

Obese mice and the satiety effects of cholecystokinin, bombesin and pancreatic polypeptide

1981 • 115 citations

Neurobiology of cholecystokinin.

1994 • 113 citations

Molecular Genetics of Human Obesity‐Associated MC4R Mutations

2003 • 112 citations

Altered levels of POMC, AgRP and MC4-R mRNA expression in the hypothalamus and other parts of the limbic system of mice prone or resistant to chronic high-energy diet-induced obesity

2003 • 112 citations

Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice☆

1999 • 112 citations

Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice

2002 • 109 citations

Evidence for the Existence of Distinct Central Appetite, Energy Expenditure, and Ghrelin Stimulation Pathways as Revealed by Hypothalamic Site-Specific Leptin Gene Therapy

2002 • 104 citations

Resistance to the Satiety Action of Leptin Following Chronic Central Leptin Infusion is Associated with the Development of Leptin Resistance in Neuropeptide Y Neurones

2002 • 100 citations

Gut hormones in tropical malabsorption.

1979 • 98 citations

Regulation of Neuropeptide Y Release by Neuropeptide Y Receptor Ligands and Calcium Channel Antagonists in Hypothalamic Slices

1999 • 98 citations

Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors

1999 • 97 citations

Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity

2004 • 97 citations

Chronic CNS administration of Agouti-related protein (Agrp) reduces energy expenditure

2003 • 96 citations

Oxyntomodulin-like immunoreactivity: diurnal profile of a new potential enterogastrone.

1992 • 96 citations

Insulin and the paraventricular hypothalamus: modulation of energy balance

1991 • 96 citations

Dynamic regulation of leptin entry into brain by the blood–brain barrier

2000 • 95 citations

Acute changes in the response to peripheral leptin with alteration in the diet composition

2001 • 95 citations

Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem

1997 • 95 citations

Plasma Enteroglucagon after Jejunoileal Bypass with 3:1 or 1:3 Jejunoileal Ratio

1979 • 93 citations

Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat

1997 • 90 citations

BLUNTED PANCREATIC POLYPEPTIDE RESPONSES IN CHILDREN WITH OBESITY OF PRADER-WILLI SYNDROME

1981 • 88 citations

Pancreatic Polypeptide Responses to Protein Meal Challenges in Obese but Otherwise Normal Children and Obese Children with Prader-Willi Syndrome*

1983 • 87 citations

Autoradiographic localization of receptors for glucagon-like peptide-1(7–36) amide in rat brain

1992 • 86 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 85 citations

Potential regulators of feeding behavior In anorexia nervosa

1992 • 85 citations

Hypothalamic Melanocortin System Regulates Sympathetic Nerve Activity in Brown Adipose Tissue

2004 • 85 citations

Orexin depolarizes rat hypothalamic paraventricular nucleus neurons

2001 • 85 citations

Stable expression of the rat GLP-I receptor in CHO cells: Activation and binding characteristics utilizing GLP-I(7–36)-amide, oxyntomodulin, exendin-4, and exendin(9–39)

1994 • 85 citations

Cannabinoid receptor antagonists and obesity.

2004 • 84 citations

Treatment of Type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors

2004 • 83 citations

Electrical activation and c‐fos mRNA expression in rat neurosecretory neurones after systemic administration of cholecystokinin.

1991 • 81 citations

Neuropeptide Y Induced Feeding in the Rat Is Mediated by a Novel Receptor

1997 • 81 citations

Repeated Intracerebroventricular Administration of Glucagon-Like Peptide-1-(7-36) Amide or Exendin-(9-39) Alters Body Weight in the Rat

1999 • 80 citations

Mechanisms of peptide YY release induced by an intraduodenal meal in rats: neural regulation by proximal gut

1997 • 80 citations

Cholecystokinin and peptide YY are released by fat in either proximal or distal small intestine in dogs

2003 • 78 citations

Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozocin-induced diabetic rats

1989 • 78 citations

Differential Regulation of Neuropeptide Y mRNA Expression in the Arcuate Nucleus and Locus Coeruleus by Stress and Antidepressants

2000 • 77 citations

CCK Elicits and Modulates Vagal Afferent Activity Arising from Gastric and Duodenal Sites

1994 • 77 citations

Intracarotid glucose selectively increases Fos-like immunoreactivity in paraventricular, ventromedial and dorsomedial nuclei neurons

1997 • 76 citations

Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats

2002 • 74 citations

Diurnal profile of pancreatic polypeptide, pancreatic glucagon, gut glucagon and insulin in human morbid obesity.

1983 • 74 citations

Effects of restricted daily feeding on neuropeptide Y release in the rat paraventricular nucleus

1996 • 74 citations

Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP

2002 • 72 citations

Role of the Y1 Receptor in the Regulation of Neuropeptide Y-Mediated Feeding: Comparison of Wild-Type, Y1 Receptor-Deficient, and Y5 Receptor-Deficient Mice

2000 • 72 citations

Increased cholecystokinin and pancreatic polypeptide responses to a fat-rich meal in patients with restrictive but not bulimic anorexia nervosa

1997 • 68 citations

Pancreatic Polypeptide Response to Secretin in Obesity: Effects of Glucose Intolerance

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Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake

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Human pancreatic polypeptide: studies of fasting and postprandial plasma concentrations

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Co-administration of dopamine D1 and D2 agonists additively decreases daily food intake, body weight and hypothalamic neuropeptide Y level in rats

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Ala67Thr polymorphism in the Agouti‐related peptide gene is associated with inherited leanness in humans

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Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

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Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynucleotides

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Effects of recombinant human leptin treatment as an adjunct of moderate energy restriction on body weight, resting energy expenditure and energy intake in obese humans.

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Differential Orexigenic Effects of Hexarelin and Its Analogs in the Rat Hypothalamus: Indication for Multiple Growth Hormone Secretagogue Receptor Subtypes

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c-fos expression in the paraventricular nucleus of the hypothalamus following intracerebroventricular infusions of neuropeptide Y

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Chronic Neuropeptide Y Infusion into the Lateral Ventricle Induces Sustained Feeding and Obesity in Mice Lacking Either Npy1r or Npy5r Expression

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The Role of the Dorsal Vagal Complex and the Vagus Nerve in Feeding Effects of Melanocortin-3/4 Receptor Stimulation

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Ghrelin Gene: Identification of Missense Variants and a Frameshift Mutation in Extremely Obese Children and Adolescents and Healthy Normal Weight Students

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Localization of Leptin Receptor (Ob-R) Messenger Ribonucleic Acid in the Rodent Hindbrain

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A tumour that secretes glucagon-like peptide-1 and somatostatin in a patient with reactive hypoglycaemia and diabetes

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Comparative effects of CCK-8 on feeding, sham feeding, and exocrine pancreatic secretion in rats

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Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus

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Effect of Circulating Peptide YY on Gallbladder Emptying in Humans

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Agouti-Related Protein Containing Nerve Terminals Innervate Thyrotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus

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Motilin is a biosignal controlling cyclic release of pancreatic polypeptide via the vagus in fasted dogs

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Infusion of cholecystokinin between meals into free-feeding rats fails to prolong the intermeal interval

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Effect of CCK antibodies on food intake and weight gain in zucker rats

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Hypocretin/Orexin‐ and melanin‐concentrating hormone‐expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene‐related protein systems

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Low plasma levels of pancreatic polypeptide in obesity

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The effect of hypothalamic peptide YY on hippocampal acetylcholine release in vivo: implications for limbic function in binge-eating behavior

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