The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

A role for glucagon-like peptide-1 in the central regulation of feeding

1996 • 1,880 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Electrophysiology of the pancreatic β-cell

1989 • 1,123 citations

Elementary and global aspects of calcium signalling.

1997 • 1,031 citations

The Glucagon-Like Peptides

1999 • 1,018 citations

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene

1996 • 771 citations

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

2000 • 590 citations

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)

1993 • 576 citations

Adenosine Diphosphate as an Intracellular Regulator of Insulin Secretion

1996 • 532 citations

Cell and Molecular Biology of the Incretin Hormones Glucagon-Like Peptide-I and Glucose-Dependent Insulin Releasing Polypeptide

1995 • 519 citations

Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2

1999 • 516 citations

Biological actions and therapeutic potential of the glucagon-like peptides

2002 • 496 citations

Defective insulin secretion and enhanced insulin action in K _ATP channel-deficient mice

1998 • 493 citations

Mechanisms of calcium channel modulation by β-adrenergic agents and dihydropyridine calcium agonists

1986 • 493 citations

The elemental principles of calcium signaling

1995 • 455 citations

CD26, let it cut or cut it down

1999 • 454 citations

Glucagon-Like Peptide-1 Induces Cell Proliferation and Pancreatic-Duodenum Homeobox-1 Expression and Increases Endocrine Cell Mass in the Pancreas of Old, Glucose-Intolerant Rats

2000 • 427 citations

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1999 • 405 citations

Minireview: The Glucagon-Like Peptides

2001 • 393 citations

Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells

1993 • 377 citations

Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion

2001 • 372 citations

Sur1 Knockout Mice

2000 • 369 citations

Glucagon-Like Peptide-1 and Exendin-4 Stimulate β-Cell Neogenesis in Streptozotocin-Treated Newborn Rats Resulting in Persistently Improved Glucose Homeostasis at Adult Age

2001 • 367 citations

Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients.

1999 • 335 citations

Regulation of a Heart Potassium Channel by Protein Kinase A and C

1988 • 317 citations

Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

1998 • 309 citations

Repeated Intracerebroventricular Administration of Glucagon-Like Peptide-1-(7–36) Amide or Exendin-(9–39) Alters Body Weight in the Rat**This work was supported by the United Kingdom Medical Research Council.

1999 • 308 citations

Protein kinase A‐dependent and ‐independent stimulation of exocytosis by cAMP in mouse pancreatic B‐cells

1997 • 302 citations

Exendin-4 Decelerates Food Intake, Weight Gain, and Fat Deposition in Zucker Rats

2000 • 295 citations

A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events

1998 • 283 citations

The U.K. Prospective Diabetes Study: A review

1998 • 266 citations

Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide

1998 • 260 citations

Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1

1998 • 258 citations

Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation

2001 • 249 citations

Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats

2002 • 237 citations

Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1–Positive Pancreatic Ductal Cells Into Insulin-Secreting Cells

2001 • 222 citations

cAMP-dependent Mobilization of Intracellular Ca2+ Stores by Activation of Ryanodine Receptors in Pancreatic β-Cells

1999 • 221 citations

Rapid ATP‐Dependent Priming of Secretory Granules Precedes Ca²⁺ ‐Induced Exocytosis in Mouse Pancreatic B‐Cells

1997 • 218 citations

Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

1993 • 214 citations

Characterization of SNARE protein expression in beta cell lines and pancreatic islets.

1996 • 195 citations

cAMP‐regulated guanine nucleotide exchange factor II (Epac2) mediates Ca²⁺‐induced Ca²⁺ release in INS‐1 pancreatic β‐cells

2001 • 194 citations

Glucagon-Like Peptide 1(7-36) Amide Stimulates Exocytosis in Human Pancreatic β-Cells by Both Proximal and Distal Regulatory Steps in Stimulus-Secretion Coupling

1998 • 188 citations

Activation of a cAMP-regulated Ca2+-Signaling Pathway in Pancreatic β-Cells by the Insulinotropic Hormone Glucagon-like Peptide-1

1995 • 185 citations

Members of the Kv1 and Kv2 Voltage-Dependent K+ Channel Families Regulate Insulin Secretion

2001 • 181 citations

PKA-mediated phosphorylation of the human KATP channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation

1999 • 179 citations

Glucagon-Like Peptide-1 Inhibits Pancreatic ATP-Sensitive Potassium Channels via a Protein Kinase A- and ADP-Dependent Mechanism

2002 • 171 citations

Chronic Inhibition of Circulating Dipeptidyl Peptidase IV by FE 999011 Delays the Occurrence of Diabetes in Male Zucker Diabetic Fatty Rats

2002 • 170 citations

Selective phosphorylation of the alpha subunit of the sodium channel by cAMP-dependent protein kinase.

1982 • 168 citations

Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.

1998 • 161 citations

Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umeå +/?)*

1999 • 153 citations

Glucagon-like peptide-1: a major regulator of pancreatic beta-cell function

2000 • 139 citations

Glucagon-Like Peptide-1 Causes Pancreatic Duodenal Homeobox-1 Protein Translocation from the Cytoplasm to the Nucleus of Pancreatic β-Cells by a Cyclic Adenosine Monophosphate/Protein Kinase A-Dependent Mechanism

2001 • 135 citations

Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed motility inhibited via nitric oxide independently of insulin and somatostatin.

1998 • 131 citations

Glucagon-Like Peptide I Increases Cytoplasmic Calcium in Insulin-Secreting βTC3-Cells by Enhancement of Intracellular Calcium Mobilization

1995 • 128 citations

β-Cell Mitochondria and Insulin Secretion

2002 • 116 citations

Beta-adrenergic modulation of cardiac ion channels. Differential temperature sensitivity of potassium and calcium currents.

1989 • 114 citations

An ATP-Sensitive Cl− Channel Current That Is Activated by Cell Swelling, cAMP, and Glyburide in Insulin-Secreting Cells

1995 • 113 citations

In situactivation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation

1998 • 109 citations

Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors

1997 • 107 citations

Localized Calcium Influx in Pancreatic β-Cells: Its Significance for Ca<sup>2+</sup>-Dependent Insulin Secretion from the Islets of Langerhans

2000 • 105 citations

Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells

2000 • 105 citations

Glucagon-like peptide-1 (7–36) amide: a central regulator of satiety and interoceptive stress

1999 • 103 citations

Glucose action `beyond ionic events' in the pancreatic β cell

1998 • 98 citations

TRP Genes

2002 • 95 citations

An alternate pathway of cAMP-stimulated Cl− secretion across the NKCC1-null murine duodenum

2002 • 94 citations

Disturbances in Glucose-Tolerance, Insulin-Release, and Stress-Induced Hyperglycemia upon Disruption of the Ca_v2.3 (α1E) Subunit of Voltage-Gated Ca²⁺Channels

2002 • 92 citations

K+ Channels: Generating Excitement in Pancreatic β-Cells

1996 • 90 citations

Oral hypoglycemic agents: insulin secretagogues, α-glucosidase inhibitors and insulin sensitizers

2001 • 90 citations

Cyclic AMP-Modulated Potassium Channels in Murine B Cells and Their Precursors

1987 • 89 citations

Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice

2001 • 88 citations

A novel membrane sodium current induced by injection of cyclic nucleotides into gastropod neurones.

1984 • 86 citations

Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets.

1998 • 86 citations

Glucagon-Like Peptide 1 Elevates Cytosolic Calcium in Pancreaticβ -Cells Independently of Protein Kinase A1

1999 • 81 citations

Glucagonlike peptide-1 (GLP-1) participation in ileal brake induced by intraluminal peptones in rat.

1999 • 76 citations

Protein Kinase A Phosphorylation Alters Kvβ1.3 Subunit-mediated Inactivation of the Kv1.5 Potassium Channel

1999 • 74 citations

Molecular basis of cardiac potassium channel stimulation by protein kinase A.

1994 • 72 citations

Phosphorylation of a K+ Channel α Subunit Modulates the Inactivation Conferred by a β Subunit

1996 • 71 citations

The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1

2001 • 68 citations

A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells.

1998 • 66 citations

AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex

2001 • 64 citations

Muscarinic Stimulation of α1E Ca Channels Is Selectively Blocked by the Effector Antagonist Function of RGS2 and Phospholipase C-β1

2000 • 54 citations

GLP-I(7–36) Amide Augments Ba2+ Current Through L-Type Ca2+ Channel of Rat Pancreatic β-Cell in a cAMP-Dependent Manner

1997 • 52 citations

Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic β-Cells (HIT)

2001 • 52 citations

Gut hormones as pharmaceuticals

2000 • 50 citations

Glucagon-like Peptide-1 Modulates Ca2+ Current But Not K+ATP Current in Intact Mouse Pancreatic B-Cells

1995 • 46 citations

Cyclic-AMP-dependent phosphorylation modulates the stereospecific activation of cardiac Ca channels by Bay K 8644

1990 • 46 citations

Signal Transduction of PACAP and GLP-1 in Pancreatic β Cellsa

2006 • 44 citations

Fast and cAMP-Sensitive Mode of Ca2+-Dependent Exocytosis in Pancreatic β-Cells

2002 • 44 citations

Cystic Fibrosis Transmembrane Conductance Regulator And The Outwardly Rectifying Chloride Channel: A Relationship Between Two Chloride Channels Expressed In Epithelial Cells

2000 • 42 citations

Mutations to the Third Cytoplasmic Domain of the Glucagon-Like Peptide 1 (GLP-1) Receptor Can Functionally Uncouple GLP-1-Stimulated Insulin Secretion in HIT-T15 Cells

1999 • 41 citations

Microdomains and elemental events in calcium signalling

1996 • 34 citations

The Calcimimetic R-467 Potentiates Insulin Secretion in Pancreatic β Cells by Activation of a Nonspecific Cation Channel

2000 • 34 citations

Effects of Glucose and Amino Acids on Free ADP in βHC9 Insulin-Secreting Cells

2001 • 32 citations

cAMP-independent decrease of ATP-sensitive K+ channel activity by GLP-1 in rat pancreatic β-cells

2000 • 31 citations

Influence of glucagon-like peptide-1 on β cell responsiveness

1993 • 31 citations

Single channel studies of the phosphorylation of K+ channels in the squid giant axon. I. Steady-state conditions.

1991 • 28 citations

Mechanisms of action of cyclic nucleotides on a bursting pacemaker and silent neuron in aplysia

1981 • 25 citations

Modulation of the inactivation of voltage-dependent potassium channels by cAMP

1995 • 25 citations

An ATP-sensitive Cl- channel current that is activated by cell swelling, cAMP, and glyburide in insulin-secreting cells

1995 • 23 citations

Glucagon‐like peptide‐1 receptor expression in Xenopus oocytes stimulates inositol trisphosphate‐dependent intracellular Ca²⁺ mobilization

1998 • 22 citations

Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization

1995 • 20 citations

Ca2+ and electrolyte mobilization following agonist application to the pancreatic β cell line HIT

2000 • 20 citations

Involvement of Calmodulin in Glucagon‐Like Peptide 1(7‐36) Amide‐Induced Inhibition of the ATP‐Sensitive K⁺ Channel in Mouse Pancreatic β‐Cells

2001 • 18 citations

K+ channels: generating excitement in pancreatic beta-cells

1996 • 17 citations

Single delayed rectifier channels in frog atrial cells. Effects of beta-adrenergic stimulation

1990 • 16 citations

Glucagon-like peptide-1 stimulates insulin secretion but not phosphoinositide hydrolysis from islets desensitized by prior exposure to high glucose or the muscarinic agonist carbachol

1996 • 14 citations

K+ channel and alpha 2-adrenergic effects on glucose-induced Ca2+i surges: aberrant behavior in ob/ob mice

1993 • 13 citations

GLP-I(7-36) amide augments Ba2+ current through L-type Ca2+ channel of rat pancreatic beta-cell in a cAMP-dependent manner

1997 • 8 citations

Cyclic AMP stimulates the gene expression of a non-selective cation channel, mNSC1, in pancreatic β-cell line, MIN6

2000 • 2 citations