Brain Stem Is a Direct Target for Leptin’s Action in the Central Nervous System

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

The stomach is a source of leptin

1998 • 1,215 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Activation of Downstream Signals by the Long Form of the Leptin Receptor

2000 • 800 citations

Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat

1981 • 788 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance

1999 • 640 citations

Cytokine-to-brain communication: A review & analysis of alternative mechanisms

1995 • 579 citations

Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice

1997 • 435 citations

Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem

1997 • 428 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels.

1997 • 374 citations

Chemical characterization of leptin-activated neurons in the rat brain

2000 • 358 citations

Brainstem Application of Melanocortin Receptor Ligands Produces Long-Lasting Effects on Feeding and Body Weight

1998 • 279 citations

Central Autonomic System

2014 • 278 citations

Lipopolysaccharide and Interleukin-1 Depress Food-Motivated Behavior in Mice by a Vagal-Mediated Mechanism

1995 • 228 citations

Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus

1998 • 217 citations

Electrical stimulation of afferent vagus nerve induces IL-1β expression in the brain and activates HPA axis

2000 • 205 citations

Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve

2001 • 195 citations

Leptin-Induced Nuclear Translocation of STAT3 Immunoreactivity in Hypothalamic Nuclei Involved in Body Weight Regulation

2001 • 192 citations

Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats

1997 • 170 citations

Localization of Leptin Receptor (Ob-R) Messenger Ribonucleic Acid in the Rodent Hindbrain*

1998 • 165 citations

The Long Form of the Leptin Receptor (OB-Rb) Is Widely Expressed in the Human Brain

2000 • 156 citations

Pro-opiomelanocortin-derived peptides (ACTH/β-endorphin/ α-MSH) in brainstem baroreceptor areas of the rat

1987 • 138 citations

Transcellular Transport of Leptin by the Short Leptin Receptor Isoform ObRa in Madin-Darby Canine Kidney Cells*

2000 • 121 citations

Leptin Signaling in the Hypothalamus of Normal Rats in Vivo**This work was supported in part by a Boston Obesity Nutrition Research Center Grant (to J.C.C.), NIH Grant DK-50411 (to R.J.S.), and NIH Diabetes and Endocrinology Center Grant DK-36836 (to R.J.S.).

1998 • 110 citations

Cholecystokinin-immunoreactive innervation of the ventromedial hypothalamus in the rat: Possible substrate for autonomic regulation of feeding

1985 • 93 citations

Leptin Receptor Immunoreactivity Is Present in Ascending Serotonergic and Catecholaminergic Neurons of the Rat

2001 • 70 citations

Leptin injected into the fourth ventricle inhibits gastric emptying

1998 • 48 citations

Peripheral gastric leptin modulates brain stem neuronal activity in neonates

1999 • 45 citations

Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats

1999 • 40 citations