The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

Central nervous system control of food intake

2000 • 6,305 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Signals That Regulate Food Intake and Energy Homeostasis

1998 • 1,190 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1999 • 1,000 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology

1986 • 944 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Genetics of body-weight regulation

2000 • 797 citations

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

1967 • 664 citations

Key enzyme in leptin-induced anorexia

2001 • 574 citations

Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin

1998 • 518 citations

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

1993 • 479 citations

SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling

2000 • 454 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade

2000 • 318 citations

Immunohistochemical signal amplification by catalyzed reporter deposition and its application in double immunostaining.

1996 • 276 citations

The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models

2000 • 265 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 226 citations

Regional Concentrations of Insulin in the Rat Brain*

1983 • 216 citations

Role of the CNS Melanocortin System in the Response to Overfeeding

1999 • 211 citations

Metabolic hormones and regulation of body weight.

1974 • 185 citations

Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion

1998 • 179 citations

Insulin in the brain: a hormonal regulator of energy balance

1992 • 167 citations

Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat

1992 • 134 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 134 citations

Targeted Deletion of the tub Mouse Obesity Gene Reveals that tubby Is a Loss-of-Function Mutation

2000 • 83 citations

STZ-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats

1999 • 77 citations

A comparison between effects of intraventricular insulin and intraperitoneal lithium chloride on three measures sensitive to emetic agents.

1995 • 58 citations