Generation of Soluble Leptin Receptor by Ectodomain Shedding of Membrane-spanning Receptors in Vitro and in Vivo

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

2002 • 2,711 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

Biological Action of Leptin as an Angiogenic Factor

1998 • 1,390 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Obesity in the new millennium

2000 • 707 citations

Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting.

1996 • 552 citations

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.

1993 • 531 citations

Regulation of fatty acid homeostasis in cells: Novel role of leptin

1999 • 442 citations

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1996 • 321 citations

Soluble Leptin Receptor Represents the Main Leptin Binding Activity in Human Blood

2001 • 294 citations

Modulation of Circulating Leptin Levels by Its Soluble Receptor

2001 • 266 citations

Hyperleptinemia of Pregnancy Associated with the Appearance of a Circulating Form of the Leptin Receptor

1997 • 248 citations

Regulation of Circulating Soluble Leptin Receptor Levels By Gender, Adiposity, Sex Steroids, and Leptin

2002 • 235 citations

In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin*

2000 • 234 citations

Leptin: a multifunctional hormone

2000 • 211 citations

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

1999 • 172 citations

Leptin and Soluble Leptin Receptor Levels in Obese and Weight-Losing Individuals

2002 • 165 citations

Fine Structure of the Murine Leptin Receptor Gene: Splice Site Suppression Is Required to Form Two Alternatively Spliced Transcripts

1997 • 154 citations

Free Leptin, Bound Leptin, and Soluble Leptin Receptor in Normal and Diabetic Pregnancies

1999 • 152 citations

Tumor Necrosis Factor-α Converting Enzyme (TACE) Is a Growth Hormone Binding Protein (GHBP) Sheddase: The Metalloprotease TACE/ADAM-17 Is Critical for (PMA-Induced) GH Receptor Proteolysis and GHBP Generation*

2000 • 139 citations

Generation of Human Soluble Leptin Receptor by Proteolytic Cleavage of Membrane-Anchored Receptors

2001 • 133 citations

Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans

2002 • 99 citations

Weight Loss Increases Soluble Leptin Receptor Levels and the Soluble Receptor Bound Fraction of Leptin

2002 • 90 citations

Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum

2002 • 83 citations

Absence of Soluble Leptin Receptor in Plasma fromdbPas/dbPas and Otherdb/db Mice

1998 • 80 citations

Free serum leptin but not bound leptin concentrations are elevated in patients with end‐stage renal disease

2000 • 42 citations

Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation

2002 • 37 citations

Mouse Placental Cells Secrete Soluble Leptin Receptor (sOB-R): cAMP Inhibits sOB-R Production

1998 • 26 citations

Quantification of the Soluble Leptin Receptor in Human Blood by Ligand-Mediated Immunofunctional Assay

2002 • 25 citations