Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

A RATING SCALE FOR DEPRESSION

1960 • 30,921 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

THE ASSESSMENT OF ANXIETY STATES BY RATING

1959 • 10,517 citations

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

2017 • 8,063 citations

Global and societal implications of the diabetes epidemic

2001 • 5,825 citations

Obesity as a medical problem

2000 • 4,948 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

1999 • 4,825 citations

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

2001 • 3,408 citations

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1995 • 3,159 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

1999 • 1,959 citations

Recombinant Leptin for Weight Loss in Obese and Lean Adults

1999 • 1,408 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,312 citations

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

2002 • 1,210 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

A leptin missense mutation associated with hypogonadism and morbid obesity

1998 • 1,187 citations

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

2001 • 1,181 citations

Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

2001 • 1,144 citations

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

2001 • 1,091 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,051 citations

Insulin-Like Growth Factors

1997 • 897 citations

Role of leptin in hypothalamic–pituitary function

1997 • 744 citations

Obesity in the new millennium

2000 • 707 citations

Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects

1999 • 688 citations

Human leptin levels are pulsatile and inversely related to pituitary–ardenal function

1997 • 632 citations

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

2003 • 555 citations

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

2003 • 541 citations

Partial leptin deficiency and human adiposity

2001 • 402 citations

Ghrelin: An orexigenic and somatotrophic signal from the stomach

2001 • 398 citations

Circulating levels of free insulin-like growth factors in obese subjects: the impact of Type 2 diabetes

1999 • 287 citations

Nitric Oxide Mediates Leptin-Induced Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH and Leptin-Induced LH Release from the Pituitary Gland

1997 • 224 citations

Leptin is suppressed during infusion of recombinant human insulin-like growth factor I (rhIGF I) in normal rats

1999 • 48 citations

Estrogen and Leptin Have Differential Effects on FSH and LH Release in Female Rats²

1999 • 29 citations

Insulin-Like Growth Factor-Binding Protein-2 Levels in Pediatric Patients with Growth Hormone Deficiency, Eating Disorders and Acute Lymphoblastic Leukemia

2000 • 27 citations

Recombinant human insulin-like growth factor-I (IGF-I) therapy decreases plasma leptin concentration in patients with chronic renal insufficiency

1998 • 26 citations