Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

1994 • 1,059 citations

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1994 • 1,055 citations

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

1993 • 844 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

Molecular characterization of the mouse agouti locus

1992 • 791 citations

Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

1993 • 719 citations

Molecular cloning of a novel melanocortin receptor.

1993 • 683 citations

Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats

1990 • 648 citations

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.

1993 • 428 citations

Evidence for two separate opiate peptide neuronal systems

1978 • 413 citations

Intracerebroventricular injections in mice

1986 • 388 citations

alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain.

1978 • 352 citations

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

1995 • 345 citations

Potent and prolonged-acting cyclic lactam analogs of .alpha.-melanotropin: design based on molecular dynamics

1989 • 308 citations

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.

1995 • 290 citations

Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse.

1993 • 276 citations

A Colorimetric Assay for Measuring Activation of Gs- and Gq-Coupled Signaling Pathways

1995 • 187 citations

Structure and function of ASP, the human homolog of the mouse agouti gene

1995 • 184 citations

[1] Assay of adenylyl cyclase catalytic activity

1991 • 119 citations

Short-Term Starvation Decreases POMC mRNA but Does Not Alter GnRH mRNA in the Brain of Adult Male Rats

1992 • 77 citations

Overexpression of anAgouticDNA in the Skin of Transgenic Mice Recapitulates Dominant Coat Color Phenotypes of Spontaneous Mutants

1996 • 73 citations

GROWTH OF INBRED YELLOW (AYa) AND NON-YELLOW (aa) MICE IN PARABIOSIS

1963 • 44 citations

A transgenic mouse assay for agouti protein activity.

1995 • 43 citations

Diurnal Rhythm in Proopiomelanocortin mRNA in the Arcuate Nucleus of the Male Rat

1994 • 41 citations