Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Obesity and the Regulation of Energy Balance

2001 • 2,387 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Leptin Inhibits Bone Formation through a Hypothalamic Relay

2000 • 2,045 citations

Leptin Regulates Bone Formation via the Sympathetic Nervous System

2002 • 1,651 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

A Highly Efficient Escherichia coli-Based Chromosome Engineering System Adapted for Recombinogenic Targeting and Subcloning of BAC DNA

2001 • 1,194 citations

From Lesions to Leptin

1999 • 1,165 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

2003 • 1,003 citations

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1999 • 1,000 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

2000 • 878 citations

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

1996 • 873 citations

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre-mediated excision

2000 • 841 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

1998 • 817 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

1998 • 797 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 562 citations

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

1999 • 549 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 533 citations

Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin

1998 • 518 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Minireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control

2003 • 385 citations

Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake

2002 • 374 citations

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY _3-36

2004 • 363 citations

Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter

2003 • 362 citations

Diabetes-Obesity Syndromes in Mice

1982 • 357 citations

Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?

2003 • 355 citations

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

2001 • 332 citations

Independent and Additive Effects of Central POMC and Leptin Pathways on Murine Obesity

1997 • 242 citations

Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats.

1993 • 202 citations

Neuropeptide Y-Mediated Inhibition of Proopiomelanocortin Neurons in the Arcuate Nucleus Shows Enhanced Desensitization in ob/ob Mice

2004 • 197 citations

A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation.

1994 • 190 citations

Neurotransmitters, neuropeptides and binding sites in the rat mediobasal hypothalamus: effects of monosodium glutamate (MSG) lesions

1989 • 183 citations

Transgenic Complementation of Leptin-Receptor Deficiency

2001 • 150 citations

Evidence that β-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA

1992 • 150 citations

Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight

2003 • 124 citations

Electrophysiological Actions of Peripheral Hormones on Melanocortin Neurons

2003 • 118 citations

Hyperphagia and Weight Gain after Gold-Thioglucose: Relation to Hypothalamic Neuropeptide Y and Proopiomelanocortin**This work was supported by grants from the Children’s Hospital Research Foundation (to H.T.B.) and the NIH (DK-50110; to C.V.M.).

1998 • 114 citations

Impaired Coordination of Nutrient Intake and Substrate Oxidation in Melanocortin-4 Receptor Knockout Mice

2003 • 95 citations

Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction

2000 • 94 citations

Lipolytic potency of proopiomelanocorticotropin peptides in vitro

1987 • 19 citations