The multifunctional or moonlighting protein CD26/DPPIV

Handbook of Proteolytic Enzymes

2004 • 2,698 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

MEROPS: the peptidase database

1999 • 1,939 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides

1999 • 1,258 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

The Handbook of proteolytic enzymes

1998 • 1,123 citations

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

1993 • 1,119 citations

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

1995 • 1,064 citations

Moonlighting proteins

1999 • 1,022 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

1992 • 800 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome

1985 • 737 citations

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

1990 • 677 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

Glucagon-Like Peptides

1998 • 548 citations

Proline-Dependent Structural and Biological Properties of Peptides and Proteins

1993 • 548 citations

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

1994 • 522 citations

Fibroblast Activation Protein, a Dual Specificity Serine Protease Expressed in Reactive Human Tumor Stromal Fibroblasts

1999 • 521 citations

Direct Association of Adenosine Deaminase with a T Cell Activation Antigen, CD26

1993 • 493 citations

Dissociated Pattern of Activity in Visual Cortices and Their Projections During Human Rapid Eye Movement Sleep

1998 • 478 citations

Prolyl Oligopeptidase

1998 • 478 citations

CD26, let it cut or cut it down

1999 • 454 citations

Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

1990 • 443 citations

A new dipeptide naphthylamidase hydrolyzing glycyl-prolyl-?-naphthylamide

1966 • 425 citations

The structure and function of CD26 in the T‐cell immune response

1998 • 423 citations

On the active site of proteases. III. Mapping the active site of papain; specific peptide inhibitors of papain

1968 • 400 citations

CD26: A Multifunctional Integral Membrane and Secreted Protein of Activated Lymphocytes

2001 • 361 citations

Type II Transmembrane Serine Proteases

2001 • 341 citations

Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage

1997 • 340 citations

In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis

1985 • 307 citations

Fibroblast activation protein: A cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis

1999 • 296 citations

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

1993 • 288 citations

Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes

2002 • 287 citations

Kinetic Investigation of Chemokine Truncation by CD26/Dipeptidyl Peptidase IV Reveals a Striking Selectivity within the Chemokine Family

2001 • 273 citations

GPI-microdomains: a role in signalling via immunoreceptors

1999 • 270 citations

Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV

1997 • 262 citations

Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide

1998 • 260 citations

Proline specific endo- and exopeptidases

1980 • 254 citations

Intestinal function in mice with small bowel growth induced by glucagon-like peptide-2

1997 • 252 citations

A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.

1994 • 242 citations

Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody.

1984 • 239 citations

Intracellular movement of cell surface receptors after endocytosis: resialylation of asialo-transferrin receptor in human erythroleukemia cells.

1985 • 229 citations

Engineering Enzyme Specificity by "Substrate-Assisted Catalysis"

1987 • 219 citations

Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response.

1996 • 209 citations

Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.

1990 • 198 citations

Processing by CD26/dipeptidyl‐peptidase IV reduces the chemotactic and anti‐HIV‐1 activity of stromal‐cell‐derived factor‐1α

1998 • 194 citations

Moonlighting Functions of Polypeptide Elongation Factor 1: From Actin Bundling to Zinc Finger Protein R1-Associated Nuclear Localization

2002 • 194 citations

A Role for Dipeptidyl Peptidase IV in Suppressing the Malignant Phenotype of Melanocytic Cells

1999 • 191 citations

Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin.

1993 • 183 citations

Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix

1989 • 179 citations

Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage

1998 • 179 citations

Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma.

1989 • 177 citations

Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors, 1F7 and VLA integrin family.

1990 • 177 citations

1F7, A novel cell surface molecule, involved in helper function of CD4 cells

1990 • 176 citations

The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity.

1993 • 175 citations

Enzymatic and extraenzymatic role of ecto‐adenosine deaminase in lymphocytes

1998 • 175 citations

Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene

1994 • 174 citations

CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO

2001 • 172 citations

A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase.

1993 • 169 citations

Lung Endothelial Dipeptidyl Peptidase IV Promotes Adhesion and Metastasis of Rat Breast Cancer Cells via Tumor Cell Surface-associated Fibronectin

1998 • 166 citations

Adenosine Deaminase-deficient Mice Generated Using a Two-stage Genetic Engineering Strategy Exhibit a Combined Immunodeficiency

1998 • 159 citations

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

2000 • 158 citations

Identification of the 170-kDa Melanoma Membrane-bound Gelatinase (Seprase) as a Serine Integral Membrane Protease

1997 • 155 citations

Truncation of Macrophage-derived Chemokine by CD26/ Dipeptidyl-Peptidase IV beyond Its Predicted Cleavage Site Affects Chemotactic Activity and CC Chemokine Receptor 4 Interaction

1999 • 154 citations

Investigation of Glucose-dependent Insulinotropic Polypeptide(1-42) and Glucagon-like Peptide-1-(7-36) Degradation by Dipeptidyl Peptidase IV Using Matrix-assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry

1996 • 153 citations

CD26/Dipeptidyl-Peptidase IV Down-Regulates the Eosinophil Chemotactic Potency, But Not the Anti-HIV Activity of Human Eotaxin by Affecting Its Interaction with CC Chemokine Receptor 3

1999 • 152 citations

1F7, a novel cell surface molecule, involved in helper function of CD4 cells.

1989 • 152 citations

Functional Comparison of Two Human Monocyte Chemotactic Protein-2 Isoforms, Role of the Amino-Terminal Pyroglutamic Acid and Processing by CD26/Dipeptidyl Peptidase IV

1998 • 151 citations

Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2 terminus.

1986 • 150 citations

Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions

1998 • 143 citations

The Cysteine-Rich Region of Dipeptidyl Peptidase IV (CD 26) Is the Collagen Binding Site

1995 • 142 citations

Targeting Dipeptidyl Peptidase IV (CD26) Suppresses Autoimmune Encephalomyelitis and Up-Regulates TGF-β1 Secretion In Vivo

2001 • 138 citations

Dipeptidyl peptidase IV: a cell surface peptidase involved in regulating T cell growth (review).

1999 • 138 citations

Liver dipeptidyl aminopeptidase IV hydrolyzes substance P

1978 • 135 citations

Posttranslational Modifications Affect the Activity of the Human Monocyte Chemotactic Proteins MCP-1 and MCP-2: Identification of MCP-2(6–76) as a Natural Chemokine Inhibitor

1998 • 131 citations

A novel pathway of human T cell activation via a 103 kD T cell activation antigen.

1987 • 130 citations

Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities?

2001 • 129 citations

Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule.

1995 • 125 citations

Involvement of Plasma Membrane Dipeptidyl Peptidase IV in Fibronectin-Mediated Adhesion of Cells on Collagen

1985 • 124 citations

Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness.

1993 • 123 citations

Successive cleavage of N-terminal Arg1-Pro2 and Lys3-Pro4 from substance P but no release of Arg1-Pro2 from bradykinin, by X-Pro dipeptidyl-aminopeptidase

1978 • 123 citations

Intestinal response to growth factors administered alone or in combination with human [Gly²]glucagon-like peptide 2

1997 • 122 citations

MEROPS: the peptidase database

2000 • 122 citations

Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation

2000 • 118 citations

Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro.

1992 • 118 citations

Dipeptidyl peptidase IV (CD 26) and aminopeptidase N (CD 13) catalyzed hydrolysis of cytokines and peptides with N‐terminal cytokine sequences

1993 • 118 citations

New Enzymatic Route for the Inactivation of Angiotensin

1968 • 117 citations

Dipeptidyl Peptidase IV (DPIV/CD26) Degradation of Glucagon

2000 • 116 citations

A collagen-binding glycoprotein on the surface of mouse fibroblasts is identified as dipeptidyl peptidase IV

1988 • 114 citations

Kinetic study of the processing by dipeptidyl‐peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion

2001 • 112 citations

Direct evidence for the binding of rat liver DPP IV to collagen in vitro

1988 • 112 citations

Dipeptidyl Peptidase IV Activity in Patients With ACE-Inhibitor-Associated Angioedema

2002 • 112 citations

Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor‐β₁ in PWM‐stimulated PBMC and T cells

1997 • 109 citations

Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family.

1992 • 108 citations

Functional role of CD26 on human B lymphocytes

1995 • 108 citations

Treatment with interferon-alpha (IFNα) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFNα-induced depressive and anxiety symptoms and immune activation

2001 • 107 citations

Fibroblast activation protein: Purification, epitope mapping and induction by growth factors

1994 • 107 citations

Comodulation of CXCR4 and CD26 in Human Lymphocytes

2001 • 106 citations

INHIBITION OF CD26/DIPEPTIDYL PEPTIDASE IV ACTIVITY IN VIVO PROLONGS CARDIAC ALLOGRAFT SURVIVAL IN RAT RECIPIENTS1,2

1997 • 105 citations

Modulation of endomorphin-2-induced analgesia by dipeptidyl peptidase IV

1999 • 104 citations

Extracellular matrix proteins in intrathymic T-cell migration and differentiation?

1993 • 100 citations

Hydrolysis and transport of proline-containing peptides in renal brush-border membrane vesicles from dipeptidyl peptidase IV-positive and dipeptidyl peptidase IV-negative rat strains.

1990 • 99 citations

Isolation and Expression of Novel Human Glutamate Carboxypeptidases with N-Acetylated α-Linked Acidic Dipeptidase and Dipeptidyl Peptidase IV Activity

1999 • 98 citations

CD26/dipeptidyl peptidase IV differentially regulates the chemotaxis of T cells and monocytes toward RANTES: possible mechanism for the switch from innate to acquired immune response

1999 • 98 citations

Sequence, Purification, and Cloning of an Intracellular Serine Protease, Quiescent Cell Proline Dipeptidase

1999 • 97 citations

Kinetics of dipeptidyl peptidase IV proteolysis of growth hormone-releasing factor and analogs

1992 • 94 citations

Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV

1997 • 94 citations

Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor.

1998 • 92 citations

A guardian angel: the involvement of dipeptidyl peptidase IV in psychoneuroendocrine function, nutrition and immune defence

2000 • 92 citations

Sialic Acids as Antigenic Determinants of Complex Carbohydrates

1988 • 90 citations

Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells.

1996 • 90 citations

Lung endothelial dipeptidyl peptidase IV is an adhesion molecule for lung-metastatic rat breast and prostate carcinoma cells.

1993 • 89 citations

Structure of membrane glutamate carboxypeptidase

1997 • 88 citations

Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter

1995 • 87 citations

Expression and localization of aminopeptidase A, aminopeptidase N, and dipeptidyl peptidase IV in benign and malignant human prostate tissue

1997 • 86 citations

Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted β propeller domain

1999 • 85 citations

The Degradation of Bioactive Peptides and Proteins by Dipeptidyl Peptidase IV from Human Placenta

1990 • 84 citations

Expression of dipeptidyl peptidase IV in rat tissues is mainly regulated at the mRNA levels

1989 • 83 citations

Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer

2000 • 82 citations

A Novel Apoptotic Pathway in Quiescent Lymphocytes Identified by Inhibition of a Post-Proline Cleaving Aminodipeptidase: A Candidate Target Protease, Quiescent Cell Proline Dipeptidase

1999 • 81 citations

Dipeptidyl peptidase IV (DPPIV) inhibits cellular invasion of melanoma cells.

2000 • 81 citations

Cross‐linking of CD26 by antibody induces tyrosine phosphorylation and activation of mitogen‐activated protein kinase

1997 • 80 citations

Dipeptidyl Peptidase IV (DP IV, CD26) in Patients with Inflammatory Bowel Disease

2001 • 79 citations

Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritis

2001 • 78 citations

Structures of Prolyl Oligopeptidase Substrate/Inhibitor Complexes

2001 • 78 citations

Secreted and membrane attractin result from alternative splicing of the humanATRNgene

2000 • 76 citations

Biochemical characterization of CD26 (dipeptidyl peptidase IV): Functional comparison of distinct epitopes recognized by various anti-CD26 monoclonal antibodies

1992 • 75 citations

Human U937 cell surface peptidase activities: characterization and degradative effect on tumor necrosis factor‐α

1992 • 73 citations

Cutting Edge: Enhanced Anti-HIV-1 Activity and Altered Chemotactic Potency of NH2-Terminally Processed Macrophage-Derived Chemokine (MDC) Imply an Additional MDC Receptor

1998 • 72 citations

The purification and properties of a particulate renal dipeptidase

1966 • 72 citations

Regulation of CD26/DPPIV gene expression by interferons and retinoic acid in tumor B cells

2000 • 72 citations

Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases

1993 • 72 citations

Enhanced HIV expression during Th2-oriented responses explained by the opposite regulatory effect of IL-4 and IFN-γ on fusin/CXCR4

1998 • 71 citations

Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis.

1994 • 71 citations

Metabolism of glucagon by dipeptidyl peptidase IV (CD26)

2001 • 71 citations

Characterization of human serum dipeptidyl peptidase IV (CD26) and analysis of its autoantibodies in patients with rheumatoid arthritis and other autoimmune diseases.

2002 • 71 citations

Endocytosis, recycling, and lysosomal delivery of brush border hydrolases in cultured human intestinal epithelial cells (Caco-2).

1990 • 68 citations

Selective decrease of CD26 expression in T cells from HIV-1-infected individuals.

1992 • 65 citations

Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles.

1997 • 65 citations

Reference Values for Plasma Dipeptidyl Peptidase IV Activity and Their Association with Other Laboratory Parameters

2001 • 63 citations

Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-β1 (TGF-β1) in stimulated mouse splenocytes and thymocytes

1997 • 62 citations

CD26/DPPIV Signal Transduction Function, but Not Proteolytic Activity, Is Directly Related to Its Expression Level on Human Th1 and Th2 Cell Lines as Detected with Living Cell Cytochemistry

2002 • 62 citations

Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collagens

1998 • 61 citations

Negative regulation of the anti‐human immunodeficiency virus and chemotactic activity of human stromal cell‐derived factor 1α by CD26/dipeptidyl peptidase IV

1998 • 60 citations

HIV infection and aging: mechanisms to explain the accelerated rate of progression in the older patient

1997 • 60 citations

Increment in the Ta1+ cells in the peripheral blood and thyroid tissue of patients with Graves' disease.

1989 • 59 citations

Caveolae/lipid rafts in fibroblast-like synoviocytes: ectopeptidase-rich membrane microdomains

2001 • 59 citations

Role of the Actin Cytoskeleton in T Cell Absorption and Internalization of Ligands from APC

2001 • 58 citations

The Binding Site of Human Adenosine Deaminase for Cd26/Dipeptidyl Peptidase IV

2000 • 57 citations

Structural relationship between lipases and peptidases of the prolyl oligopeptidase family

1992 • 57 citations

Malignant transformation of human melanocytes: induction of a complete melanoma phenotype and genotype.

1992 • 57 citations

Alterations in plasma dipeptidyl peptidase IV enzyme activity in depression and schizophrenia: effects of antidepressants and antipsychotic drugs

1996 • 55 citations

Rump white inversion in the mouse disrupts dipeptidyl aminopeptidase-like protein 6 and causes dysregulation of Kit expression

1998 • 55 citations

The HELLGH Motif of Rat Liver Dipeptidyl Peptidase III Is Involved in Zinc Coordination and the Catalytic Activity of the Enzyme

1999 • 54 citations

Dipeptidyl peptidase IV (CD26) in metabolism and immune response

1995 • 54 citations

Amino‐terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV (DP IV)

2000 • 53 citations

Genetic evidence for role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides

1993 • 52 citations

Lowered Serum Dipeptidyl Peptidase IV Activity is Associated with Depressive Symptoms and Cytokine Production in Cancer Patients Receiving Interleukin-2-Based Immunotherapy

2001 • 51 citations

Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells

2001 • 51 citations

Characterization of the plasminogen receptors of normal and rheumatoid arthritis human synovial fibroblasts.

1994 • 51 citations

Dipeptidyl‐Peptidase IV‐β, a Novel form of Cell‐Surface‐Expressed Protein with Dipeptidyl‐Peptidase IV Activity

1996 • 50 citations

Membrane-bound peptidases of lymphocytes: functional implications.

1991 • 50 citations

Transcripts encoding a neural membrane CD26 peptidase-like protein are stimulated by synaptic activity

1994 • 50 citations

Effect of Aging and Diabetes on the Enteroinsular Axis

2001 • 49 citations

FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation

1990 • 49 citations

Ligand-Induced TCR Down-Regulation Is Not Dependent on Constitutive TCR Cycling

2002 • 48 citations

Cloning and sequence analysis of the X-Prolyl-dipeptidyl-aminopeptidase gene (pepX) from Lactobacillus delbr�ckii ssp. lactis DSM7290

1993 • 48 citations

Increased population of high fluorescence 1F7 (CD26) antigen on T cells in synovial fluid of patients with rheumatoid arthritis.

1996 • 46 citations

Porphyromonas gingivalis DPP-7 Represents a Novel Type of Dipeptidylpeptidase

2001 • 45 citations

Occupancy of dipeptidyl peptidase IV activates an associated tyrosine kinase and triggers an apoptotic signal in human hepatocarcinoma cells

1998 • 45 citations

Prolidase from Bovine Intestine: Purification and Characterization1

1983 • 44 citations

The Cleavage of Prolyl Peptides by Kidney Peptidases

1970 • 44 citations

Soluble CD30 is more relevant to disease activity of atopic dermatitis than soluble CD26

2000 • 42 citations

Activities of dipeptidyl peptidase II and dipeptidyl peptidase IV in mice with lupus erythematosus-like syndrome and in patients with lupus erythematosus and rheumatoid arthritis.

1987 • 40 citations

Caveolae/lipid rafts in fibroblast-like synoviocytes: ectopeptidase-rich membrane microdomains

2001 • 40 citations

Alterations in Structure and Cellular Localization of Molecular Forms of DP IV/CD26 during T Cell Activation

1996 • 40 citations

Dipeptidyl peptidase IV (DPP-IV) from pig kidney cleaves analogs of bovine growth hormone-releasing factor (bGRF) modified at position 2 with Ser, Thr or Val. Extended DPP-IV substrate specificity?

1993 • 39 citations

EFFECTS OF PSYCHOLOGICAL STRESS ON SERUM PROLYL ENDOPEPTIDASE AND DIPEPTIDYL PEPTIDASE IV ACTIVITY IN HUMANS: HIGHER SERUM PROLYL ENDOPEPTIDASE ACTIVITY IS RELATED TO STRESS-INDUCED ANXIETY

1998 • 39 citations

Endo- and exocytic rate constants for spontaneous and protein kinase C-activated T cell receptor cycling

2002 • 39 citations

Dipeptidyl peptidase activity of CD26 in serum and urine as a marker of cholestasis: Experimental and clinical evidence

1999 • 39 citations

Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells

2001 • 38 citations

Unchanged Signaling Capacity of Mutant CD26/Dipeptidylpeptidase IV Molecules Devoid of Enzymatic Activity

1995 • 37 citations

Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7

1993 • 36 citations

Metabolism of enterostatin in rat intestine, brain membranes, and serum: Differential involvement of proline-specific peptidases

1995 • 36 citations

Beeinflußt Dipeptidylpeptidase IV Blutdruck und Gerinnung?

1984 • 36 citations

The Significance of Hypersialylation of Dipeptidyl Peptidase IV (CD26) in the Inhibition of Its Activity by Tat and Other Cationic Peptides. CD26: A Subverted Adhesion Molecule for HIV Peptide Binding

1998 • 36 citations

Recycling of 5′-nucleotidase in a rat hepatoma cell line.

1988 • 36 citations

Cellular Peptidases in Immune Functions and Diseases 2

2002 • 36 citations

Dipeptidyl peptidase IV (DP IV, CD26) is involved in regulation of DNA synthesis in human keratinocytes

1998 • 35 citations

Activities of dipeptidyl peptidase II and dipeptidyl peptidase IV in mice with lupus erythematosus-like syndrome and in patients with lupus erythematosus and rheumatoid arthritis.

1987 • 35 citations

Peptidase activities in serum and bronchoalveolar lavage fluid from allergic asthmatics — comparison with healthy non‐smokers and smokers and effects of inhaled glucocorticoids

1999 • 34 citations

Dipeptidyl peptidase IV in patients with systemic lupus erythematosus.

1992 • 32 citations

Glycylprolyl-diaminopeptidase in human leukocytes: selective occurrence in T lymphocytes and influence on the total serum enzyme activity

1984 • 32 citations

Serum Dipeptidyl Peptidase IV (DPP IV, CD26) Activity in Chronic Hepatitis C

2001 • 32 citations

Lower serum activity of prolyl endopeptidase in fibromyalgia is related to severity of depressive symptoms and pressure hyperalgesia

1998 • 31 citations

Enzymatic Activity of CD26 (Dipeptidylpeptidase IV) is not Required for Its Signalling Function in T Cells

1993 • 31 citations

Potentiation of the immune response in HIV-1+ individuals.

1996 • 30 citations

Increment of Tal positive cells in peripheral blood from patients with rheumatoid arthritis.

1989 • 28 citations

Effect of age on human immunodeficiency virus type 1-induced changes in lymphocyte populations among persons with congenital clotting disorders. Transfusion Safety Study Group

1992 • 27 citations

Activity of dipeptidyl peptidase IV and post-proline cleaving enzyme in sera from osteoporotic patients.

1988 • 27 citations

Expression of dipeptidyl‐peptidase IV (CD26) on CD8⁺ T cells is significantly decreased in patients with psoriasis vulgaris and atopic dermatitis

2001 • 26 citations

Increased activity of dipeptidyl peptidase IV in serum of hepatoma-bearing rats coincides with the loss of the enzyme from the hepatoma plasma membrane

1986 • 26 citations

Decreased Dipeptidyl Peptidase IV Enzyme Activity of Plasma Soluble CD26 and Its Inverse Correlation with HIV-1 RNA in HIV-1 Infected Individuals

1999 • 26 citations

Plasminogen activation stimulates an increase in intracellular calcium in human synovial fibroblasts.

1993 • 24 citations

Expression of CD26 (Dipeptidyl Peptidase IV) on Memory and Naive T Lymphocytes

1992 • 24 citations

Alterations in Expression and in Serum Activity of Dipeptidyl Peptidase IV (DPP IV, CD26) in Patients with Hyporectic Eating Disorders

1999 • 22 citations

T-Cell Immune Parameters and Depression in Patients With Crohn's Disease

2002 • 22 citations

Elevated serum dipeptidyl peptidase IV (CD26, EC 3.4.14.5) activity in experimental liver cirrhosis

2000 • 22 citations

Deterioration of cellular immunity during aging

1987 • 21 citations

Complementary action of dipeptidyl peptidase IV and aminopeptidase M in the digestion of β-casein

1986 • 20 citations

Serum dipeptidyl peptidase (DPP) IV activities in oral cancer patients

1982 • 20 citations

Surface membrane CD4 turnover in phorbol ester stimulated T‐lymphocytes

1990 • 20 citations

Down-regulation of cell surface CD4 molecule expression induced by anti-CD4 antibodies in human T lymphocytes

1992 • 19 citations

Oligosaccharide Reprocessing and Recycling of a Cell Surface Glycoprotein in Cultured rat Hepatocytes

1993 • 19 citations

Metastasis

1998 • 18 citations

Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity

2006 • 18 citations

Dipeptidyl Peptidase IV in CG Rat Glioma Cell Line Differentiation

1998 • 18 citations

[Catalytic mechanism of dipeptidyl-peptidase IV].

1978 • 18 citations

Dipeptidyl-peptidase II is related to lysosomal Pro-X carboxypeptidase

1996 • 17 citations

Cloning and functional expression of rat kidney dipeptidyl peptidase II

2001 • 16 citations

Decreased expression and release of dipeptidyl peptidase IV (CD26) in cultured peripheral blood T lymphocytes of oral cancer patients

1998 • 16 citations

Dipeptidyl peptidase IV (DP IV) activity in serum and on lymphocytes of MRL/Mp-lpr/lpr mice correlates with disease onset

1994 • 16 citations

Cloning and functional expression of rat kidney dipeptidyl peptidase II

2001 • 15 citations

Lower Activity of Serum Peptidases in Abstinent Alcohol-Dependent Patients

1999 • 14 citations

Isolation and identification of naturally modified C-C chemokines MCP-1, MCP-2 and RANTES: effects of posttranslational modifications on receptor usage, chemotactic and anti-HIV-1 activity.

1998 • 13 citations

Plasmin(ogen) carbohydrate chains mediate binding to dipeptidyl peptidase IV (CD 26) in rheumatoid arthritis human synovial fibroblasts

1998 • 13 citations

Inhibition of Dipeptidyl Peptidase IV (DP IV, CD26) Activity Abrogates Stress‐Induced, Cytokine‐Mediated Murine Abortions

2001 • 13 citations

Processing of pro-colipase and trypsinogen by pancreatic dipeptidyl peptidase IV.

1986 • 13 citations

Dipeptidyl peptidase IV is down‐regulated in rat hepatoma cells at the mRNA level

1993 • 12 citations

Relating Structure to Function in the Beta-Propeller Domain of Dipeptidyl Peptidase IV

2006 • 12 citations

Effect of age on human immunodeficiency virus type 1-induced changes in lymphocyte populations among persons with congenital clotting disorders. Transfusion Safety Study Group

1992 • 12 citations

Human immunodeficiency virus 1 retropepsin

2004 • 10 citations

A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not pain perception

1986 • 10 citations

[Adenosine deaminase isoenzymes in patients with Graves' disease].

1995 • 8 citations

Expression of Dipeptidylpeptidase IV (DPP IV/CD26) Activity on Human Myeloid and B Lineage Cells, and Cell Growth Suppression by the Inhibition of DPP IV Activity

1997 • 8 citations

On the stability of immunoreactive glucagon in plasma samples

1981 • 8 citations

Age-related structural modulation of T lymphocyte-associated CD45 isoforms

2000 • 7 citations

Expression of CD26 and DPP IV in T-acute lymphoblastic leukemia: comparison of immunocytochemistry with enzyme cytochemistry.

1999 • 7 citations

Expression of Dipeptidylaminopeptidase-IV in Some Human T and B Cell Lines

1986 • 6 citations

[Diagnostic value of the enzyme dipeptidyl peptidase IV (DP IV) in abdominal cancers].

1986 • 5 citations

Heterogeneity of dipeptidyl peptidase IV from C6 rat glioma cells.

2000 • 5 citations

Further Characterization of DPP IV-β, a Novel Cell Surface Expressed Protein with Dipeptidyl Peptidase Activity

1997 • 5 citations

Stability of Endogenous Immunoreactive Glucagon (IRG) in Animal Blood

1983 • 4 citations

Proteolytic signals from Magdeburg

2000 • 4 citations

CD26 and DPP IV expression in T acute lymphoblastic leukemia cells: immunocytochemistry and enzyme cytochemistry.

1999 • 4 citations

A Molecular Model of the Active Site of Dipeptidyl Peptidase IV

1997 • 2 citations

gamma-Glutamyltranspeptidase and dipeptidyl peptidase IV activity in the serum of normal and hepatoma-bearing chickens and in the plasma membranes from liver and hepatoma Mc-29.

1992 • 2 citations

Deleted Work

1955 • 0 citations