The Inflammasomes

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

The Inflammasome

2002 • 5,445 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Gout-associated uric acid crystals activate the NALP3 inflammasome

2006 • 4,851 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Cryopyrin activates the inflammasome in response to toxins and ATP

2006 • 2,874 citations

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

2008 • 2,815 citations

Pyroptosis: host cell death and inflammation

2009 • 2,711 citations

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

2009 • 2,507 citations

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

2008 • 2,505 citations

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

2009 • 2,348 citations

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

2009 • 2,335 citations

The Inflammasomes: Guardians of the Body

2009 • 2,308 citations

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

2008 • 2,199 citations

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

2008 • 1,899 citations

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 • 1,769 citations

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

2009 • 1,699 citations

Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

2007 • 1,683 citations

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

2004 • 1,663 citations

Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever

1997 • 1,502 citations

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

2003 • 1,435 citations

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

2009 • 1,435 citations

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

2007 • 1,352 citations

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

2006 • 1,104 citations

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

2006 • 1,097 citations

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

2010 • 1,050 citations

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

2009 • 1,021 citations

Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

2006 • 999 citations

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

2007 • 953 citations

Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1

2006 • 947 citations

CARD15 mutations in Blau syndrome

2001 • 945 citations

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

2008 • 920 citations

The NLR Gene Family: A Standard Nomenclature

2008 • 885 citations

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

2006 • 882 citations

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

2009 • 869 citations

The Nalp3 inflammasome is essential for the development of silicosis

2008 • 844 citations

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

2006 • 839 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Autophagy, Immunity, and Microbial Adaptations

2009 • 827 citations

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

2009 • 812 citations

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

2009 • 799 citations

Inflammatory caspases and inflammasomes: master switches of inflammation

2006 • 784 citations

Spectrum of clinical features in Muckle‐Wells syndrome and response to anakinra

2004 • 746 citations

ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

2006 • 733 citations

Superoxide is the major reactive oxygen species regulating autophagy

2009 • 733 citations

NALPs: a novel protein family involved in inflammation

2003 • 727 citations

A pilot study of IL-1 inhibition by anakinra in acute gout

2007 • 717 citations

Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

2006 • 681 citations

Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

2007 • 680 citations

NALP1in Vitiligo-Associated Multiple Autoimmune Disease

2007 • 602 citations

Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.

1993 • 600 citations

Efficacy and safety of rilonacept (interleukin‐1 trap) in patients with cryopyrin‐associated periodic syndromes: Results from two sequential placebo‐controlled studies

2008 • 562 citations

NLRX1 is a regulator of mitochondrial antiviral immunity

2008 • 551 citations

Role of active oxygen species and NO in plant defence responses

1999 • 550 citations

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

2004 • 547 citations

Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

2006 • 527 citations

Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages

2007 • 525 citations

Activation of antibacterial autophagy by NADPH oxidases

2009 • 525 citations

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

2007 • 522 citations

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

2006 • 517 citations

The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

2007 • 503 citations

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome

2007 • 492 citations

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

2009 • 489 citations

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

2006 • 485 citations

Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway

2003 • 482 citations

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

2008 • 475 citations

TXNIP Regulates Peripheral Glucose Metabolism in Humans

2007 • 465 citations

Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans

2006 • 455 citations

Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf

2006 • 445 citations

Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder

2002 • 442 citations

Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1

2001 • 439 citations

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses

2007 • 412 citations

Targeted Disruption of Pyrin, the FMF Protein, Causes Heightened Sensitivity to Endotoxin and a Defect in Macrophage Apoptosis

2003 • 409 citations

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

2009 • 395 citations

Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity

2007 • 392 citations

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

2009 • 382 citations

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

2009 • 378 citations

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

2008 • 376 citations

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

2009 • 367 citations

A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

2008 • 360 citations

Mutations in NALP12 cause hereditary periodic fever syndromes

2008 • 358 citations

A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses

2009 • 352 citations

Modulation of intracellular ROS levels by TIGAR controls autophagy

2009 • 348 citations

Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria

2007 • 343 citations

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

2009 • 342 citations

Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization

2005 • 338 citations

Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity

2009 • 329 citations

Mechanisms of caspase-1 activation by P2X₇ receptor-mediated K⁺ release

2004 • 325 citations

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

2006 • 317 citations

The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock

2007 • 313 citations

Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1

2007 • 310 citations

Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy

2009 • 310 citations

NLRX1 is a mitochondrial NOD‐like receptor that amplifies NF‐κB and JNK pathways by inducing reactive oxygen species production

2008 • 299 citations

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

2008 • 287 citations

Pseudomonas aeruginosa activates caspase 1 through Ipaf

2008 • 287 citations

The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study

2009 • 286 citations

TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system

2007 • 285 citations

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

2009 • 284 citations

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

2009 • 281 citations

Critical role for Ipaf in Pseudomonas aeruginosa‐induced caspase‐1 activation

2007 • 255 citations

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

1997 • 255 citations

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

2009 • 244 citations

Germline Mutation in NLRP2 (NALP2) in a Familial Imprinting Disorder (Beckwith-Wiedemann Syndrome)

2009 • 226 citations

A pilot study to evaluate the safety and efficacy of the long‐acting interleukin‐1 inhibitor rilonacept (interleukin‐1 trap) in patients with familial cold autoinflammatory syndrome

2008 • 221 citations

Txnip balances metabolic and growth signaling via PTEN disulfide reduction

2008 • 205 citations

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

2009 • 184 citations

IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients

2005 • 179 citations

Pure Hemozoin Is Inflammatory In Vivo and Activates the NALP3 Inflammasome via Release of Uric Acid

2009 • 177 citations

Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila

2009 • 175 citations

Spread of an Inactive Form of Caspase-12 in Humans Is Due to Recent Positive Selection

2006 • 168 citations

Injection of Flagellin into the Host Cell Cytosol by Salmonella enterica Serotype Typhimurium

2007 • 162 citations

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

2009 • 135 citations

Interleukin-1 beta targeted therapy for type 2 diabetes

2009 • 125 citations

Innate Immune Sensing of Microbes by Nod Proteins

2006 • 120 citations

Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome

2007 • 119 citations

Successful treatment of resistant pseudogout with anakinra

2008 • 114 citations

The future of the IL-1 receptor antagonist anakinra: from rheumatoid arthritis to adult-onset Still's disease and systemic-onset juvenile idiopathic arthritis

2008 • 99 citations

Thioredoxin Binding Protein-2/Thioredoxin-Interacting Protein Is a Critical Regulator of Insulin Secretion and Peroxisome Proliferator-Activated Receptor Function

2008 • 91 citations

CA-074Me Protection against Anthrax Lethal Toxin

2009 • 89 citations

Mechanism of Bcl-2 and Bcl-X _L inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization

2009 • 84 citations

Dendritic Cell-specific MHC Class II Transactivator Contains a Caspase Recruitment Domain That Confers Potent Transactivation Activity

2001 • 76 citations

Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS)

2009 • 72 citations

Lack of TXNIP protects β-cells against glucotoxicity

2008 • 43 citations

SERUM URATE IN RELATIVES OF GOUTY PATIENTS 12

1940 • 43 citations

A role for Nod-like receptors in autophagy induced byShigellainfection

2008 • 41 citations

Autophagy and the Immune Response to TB

2009 • 37 citations