Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

Principles and Practice of Infectious Diseases.

1991 • 12,590 citations

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

2004 • 1,663 citations

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

2001 • 1,593 citations

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

2006 • 1,099 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

1998 • 761 citations

Spectrum of clinical features in Muckle‐Wells syndrome and response to anakinra

2004 • 746 citations

Chronic Infantile Neurological Cutaneous and Articular Syndrome Is Caused by Mutations in CIAS1, a Gene Highly Expressed in Polymorphonuclear Cells and Chondrocytes

2002 • 732 citations

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin‐associated autoinflammatory diseases

2002 • 693 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

“Inflammatory” Cytokines

2000 • 499 citations

Blocking IL-1 in systemic inflammation

2005 • 497 citations

PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing

2002 • 362 citations

Familial autoinflammatory diseases: genetics, pathogenesis and treatment

2005 • 352 citations

Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

2002 • 350 citations

Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization

2005 • 338 citations

A Chronic, Infantile, Neurological, Cutaneous and Articular (CINCA) Syndrome. A Specific Entity Analysed in 30 Patients

1987 • 283 citations

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF‐κB and caspase‐1

2002 • 267 citations

PYPAF1, a PYRIN-containing Apaf1-like Protein That Assembles with ASC and Regulates Activation of NF-κB

2002 • 267 citations

Cryopyrin-induced Interleukin 1β Secretion in Monocytic Cells

2004 • 233 citations

Cutting Edge: CIAS1/Cryopyrin/PYPAF1/NALP3/ CATERPILLER 1.1 Is an Inducible Inflammatory Mediator with NF-κB Suppressive Properties

2003 • 195 citations

Interleukin‐1 blockade by anakinra improves clinical symptoms in patients with neonatal‐onset multisystem inflammatory disease

2005 • 156 citations

Arthropathy with rash, chronic meningitis, eye lesions, and mental retardation

1981 • 156 citations

Cytokines and Fever: Mechanisms and Sites of Action

1998 • 153 citations

Multiple cerebral metastases: detectability with Gd-DTPA-enhanced MR imaging.

1987 • 129 citations

Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1β

2001 • 104 citations

Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury

2002 • 98 citations

Rapid automated enzyme immunoassay of serum amyloid A.

1994 • 59 citations

Structural, expression, and evolutionary analysis of mouse CIAS1

2004 • 54 citations

Rapid automated enzyme immunoassay of serum amyloid A

1994 • 53 citations

Interleukin (IL)-6, But Not IL-1, Induction in the Brain Downstream of Cyclooxygenase-2 Is Essential for the Induction of Febrile Response against Peripheral IL-1α

2004 • 37 citations

Enhancement of Cerebral Diseases: How Much Contrast Agent Is Enough?

2001 • 27 citations