Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria

The Inflammasome

2002 • 5,445 citations

Cryopyrin activates the inflammasome in response to toxins and ATP

2006 • 2,874 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 • 1,769 citations

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor

2006 • 1,343 citations

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

2004 • 1,178 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

2006 • 1,104 citations

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

2006 • 1,099 citations

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

2006 • 1,097 citations

NODs: intracellular proteins involved in inflammation and apoptosis

2003 • 1,041 citations

The type III secretion injectisome

2006 • 1,021 citations

The P2X7 Receptor: A Key Player in IL-1 Processing and Release

2006 • 986 citations

P2X receptors as cell-surface ATP sensors in health and disease

2006 • 827 citations

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

2005 • 764 citations

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

1994 • 725 citations

Autophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole

2006 • 619 citations

Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

2006 • 497 citations

Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response

2002 • 492 citations

Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity.

1984 • 471 citations

Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf

2006 • 445 citations

The cell biology ofListeria monocytogenesinfection

2002 • 430 citations

Phospholipases C and A ₂ control lysosome-mediated IL-1β secretion: Implications for inflammatory processes

2004 • 399 citations

Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis

2005 • 389 citations

The Crohn's Disease Protein, NOD2, Requires RIP2 in Order to Induce Ubiquitinylation of a Novel Site on NEMO

2004 • 378 citations

Mechanisms of caspase-1 activation by P2X₇ receptor-mediated K⁺ release

2004 • 325 citations

NAD-Induced T Cell Death

2003 • 312 citations

Innate recognition of bacteria by a macrophage cytosolic surveillance pathway

2002 • 282 citations

Potassium-inhibited processing of IL-1 beta in human monocytes.

1995 • 282 citations

Kinetics and Mechanism of ATP-Dependent IL-1β Release from Microglial Cells

2000 • 277 citations

ATP Acts as an Agonist to Promote Stimulus-Induced Secretion of IL-1β and IL-18 in Human Blood

2000 • 247 citations

Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1औ Posttranslational Processing

2003 • 194 citations

Potentiation of Caspase-1 Activation by the P2X7 Receptor Is Dependent on TLR Signals and Requires NF-κB-Driven Protein Synthesis

2005 • 193 citations

Physiological Concentrations of K+ Inhibit Cytochrome c-dependent Formation of the Apoptosome

2001 • 193 citations

Activation of the Native 45-kDa Precursor Form of Interleukin-1-converting Enzyme

1996 • 193 citations

A specific gene expression program triggered by Gram-positive bacteria in the cytosol

2004 • 192 citations

Internalization and phagosome escape required forFrancisellato induce human monocyte IL-1β processing and release

2005 • 185 citations

ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules

2004 • 181 citations

Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes

2006 • 173 citations

Nucleotide-Binding Oligomerization Domain-Like Receptors: Intracellular Pattern Recognition Molecules for Pathogen Detection and Host Defense

2006 • 144 citations

New insights into the mechanism of IL-1β maturation

2003 • 141 citations

ATP Treatment of Human Monocytes Promotes Caspase-1 Maturation and Externalization

1999 • 138 citations

Extracellular ATP induces a large nonselective conductance in macrophage plasma membranes.

1988 • 134 citations

The inflammatory caspases: guardians against infections and sepsis

2006 • 121 citations

Human Monocyte Interleukin-1β Posttranslational Processing

1996 • 102 citations

P2X7 Receptors Regulate NKT Cells in Autoimmune Hepatitis

2006 • 98 citations

Increased Mature Interleukin-1β (IL-1β) Secretion from THP-1 Cells Induced by Nigericin Is a Result of Activation of p45 IL-1β-converting Enzyme Processing

1998 • 80 citations

A Wave in the Earth

1996 • 62 citations

Human monocyte stimulus-coupled IL-1β posttranslational processing: modulation via monovalent cations

1998 • 62 citations

Human monocyte ATP-induced IL-1β posttranslational processing is a dynamic process dependent on in vitro growth conditions

1997 • 27 citations