Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Gout-associated uric acid crystals activate the NALP3 inflammasome

2006 • 4,851 citations

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

2008 • 2,815 citations

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

2008 • 2,505 citations

The Inflammasomes: Guardians of the Body

2009 • 2,308 citations

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

2008 • 2,199 citations

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 • 1,769 citations

Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

2007 • 1,683 citations

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

2004 • 1,663 citations

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

2007 • 1,352 citations

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

2008 • 920 citations

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

2009 • 738 citations

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

2008 • 705 citations

Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression

1999 • 696 citations

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

2004 • 568 citations

TXNIP Regulates Peripheral Glucose Metabolism in Humans

2007 • 465 citations

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses

2007 • 412 citations

Activating Mutations in Kir6.2 and Neonatal Diabetes

2005 • 410 citations

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

2009 • 378 citations

Thioredoxin-Interacting Protein Is Stimulated by Glucose through a Carbohydrate Response Element and Induces β-Cell Apoptosis

2005 • 345 citations

Thioredoxin-Interacting Protein

2008 • 320 citations

The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1β processing

2007 • 303 citations

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke

2008 • 273 citations

Critical role for Ipaf in Pseudomonas aeruginosa‐induced caspase‐1 activation

2007 • 255 citations

REPRODUCIBLE HIGH YIELD OF RAT ISLETS BY STATIONARY IN VITRO DIGESTION FOLLOWING PANCREATIC DUCTAL OR PORTAL VENOUS COLLAGENASE INJECTION1

1987 • 220 citations

Thioredoxin‐interacting protein deficiency induces Akt/Bcl‐xL signaling and pancreatic beta‐cell mass and protects against diabetes

2008 • 208 citations

Txnip balances metabolic and growth signaling via PTEN disulfide reduction

2008 • 205 citations

Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide

2006 • 189 citations

Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2

2008 • 164 citations

High glucose induces IL-1β expression in human monocytes: mechanistic insights

2007 • 152 citations

Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

2004 • 143 citations

VDUP1 Is Required for the Development of Natural Killer Cells

2005 • 140 citations

Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome

2007 • 120 citations

Diverse functions of VDUP1 in cell proliferation, differentiation, and diseases.

2007 • 104 citations

Thioredoxin Binding Protein-2/Thioredoxin-Interacting Protein Is a Critical Regulator of Insulin Secretion and Peroxisome Proliferator-Activated Receptor Function

2008 • 91 citations

Hyperglycemia regulates thioredoxin-ROS activity through induction of thioredoxin-interacting protein (TXNIP) in metastatic breast cancer-derived cells MDA-MB-231

2007 • 86 citations

Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus

2007 • 47 citations

Subclinical inflammation/oxidation as revealed by altered gene expression profiles in subjects with impaired glucose tolerance and Type 2 diabetes patients

2009 • 47 citations

Dendritic cells derived from TBP‐2‐deficient mice are defective in inducing T cell responses

2008 • 33 citations