Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

The Inflammasome

2002 • 5,445 citations

EMAN: Semiautomated Software for High-Resolution Single-Particle Reconstructions

1999 • 2,456 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

SPIDER and WEB: Processing and Visualization of Images in 3D Electron Microscopy and Related Fields

1996 • 2,073 citations

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 • 1,769 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Analysis of Molecular Masses and Oligomeric States of Protein Complexes by Blue Native Electrophoresis and Isolation of Membrane Protein Complexes by Two-Dimensional Native Electrophoresis

1994 • 1,211 citations

AAA+ proteins: have engine, will work

2005 • 1,149 citations

NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease

2005 • 970 citations

A Unified Model for Apical Caspase Activation

2003 • 946 citations

Three-Dimensional Structure of the Apoptosome

2002 • 879 citations

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

2006 • 839 citations

Tlr4: central component of the sole mammalian LPS sensor

2000 • 764 citations

NLRs join TLRs as innate sensors of pathogens

2005 • 663 citations

XMIPP: a new generation of an open-source image processing package for electron microscopy

2004 • 475 citations

IL-1β-converting enzyme (caspase-1) in intestinal inflammation

2001 • 408 citations

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

2006 • 355 citations

CATERPILLERs, pyrin and hereditary immunological disorders

2006 • 345 citations

Structure of the apoptotic protease-activating factor 1 bound to ADP

2005 • 337 citations

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

2006 • 317 citations

Formation of apoptosome is initiated by cytochrome c -induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1

2005 • 311 citations

The Apoptosome Activates Caspase-9 by Dimerization

2006 • 279 citations

ICEBERG

2000 • 267 citations

A combinatorial approach for determining protease specificities: application to interleukin-1β converting enzyme (ICE)

1997 • 255 citations

Structure of the CED-4–CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans

2005 • 217 citations

Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP

2003 • 205 citations

Caspases and apoptosis

2002 • 191 citations

A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis

2001 • 183 citations

A novel three-dimensional variant of the watershed transform for segmentation of electron density maps

2002 • 176 citations

Nucleotide Requirements for the in Vitro Activation of the Apoptosis Protein-activating Factor-1-mediated Caspase Pathway

2000 • 171 citations

COP, a Caspase Recruitment Domain-containing Protein and Inhibitor of Caspase-1 Activation Processing

2001 • 163 citations

Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses

2004 • 162 citations

The PYRIN Connection

2004 • 108 citations

Modeling AAA+ ring complexes from monomeric structures

2006 • 57 citations