Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

The Inflammasome

2002 • 5,445 citations

Gout-associated uric acid crystals activate the NALP3 inflammasome

2006 • 4,851 citations

Cryopyrin activates the inflammasome in response to toxins and ATP

2006 • 2,874 citations

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

2008 • 2,815 citations

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

2008 • 2,505 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 • 1,769 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

2008 • 1,465 citations

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

2007 • 1,352 citations

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

2006 • 1,104 citations

Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1

2006 • 947 citations

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

2009 • 869 citations

The Nalp3 inflammasome is essential for the development of silicosis

2008 • 844 citations

Immunological processes in malaria pathogenesis

2005 • 656 citations

Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9

2007 • 557 citations

Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages

2007 • 530 citations

The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

2007 • 503 citations

Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway

2003 • 482 citations

Regulation of membrane traffic by phosphoinositide 3-kinases

2006 • 427 citations

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses

2007 • 412 citations

Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice

1995 • 365 citations

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

2006 • 355 citations

Mechanisms of caspase-1 activation by P2X₇ receptor-mediated K⁺ release

2004 • 325 citations

Primer: inflammasomes and interleukin 1β in inflammatory disorders

2008 • 302 citations

Lipid rafts and membrane traffic

2007 • 298 citations

NOD-like receptors (NLRs): bona fide intracellular microbial sensors

2008 • 287 citations

Pyrin Activates the ASC Pyroptosome in Response to Engagement by Autoinflammatory PSTPIP1 Mutants

2007 • 269 citations

Receptor-Independent, Direct Membrane Binding Leads to Cell-Surface Lipid Sorting and Syk Kinase Activation in Dendritic Cells

2008 • 263 citations

Src-family kinases: rheostats of immune cell signaling

2004 • 233 citations

The Caspase-1 Inflammasome: A Pilot of Innate Immune Responses

2008 • 216 citations

Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin

2003 • 184 citations

Collaboration between the innate immune receptors dectin‐1, TLRs, and Nods

2007 • 183 citations

Gain- and Loss-of-Function Lyn Mutant Mice Define a Critical Inhibitory Role for Lyn in the Myeloid Lineage

2001 • 167 citations

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappaB and pro-caspase-1 regulation

2003 • 161 citations

Crystal‐induced neutrophil activation

2009 • 159 citations

Pathological role of Toll-like receptor signaling in cerebral malaria

2006 • 156 citations

Malaria-specific metabolite hemozoin mediates the release of several potent endogenous pyrogens (TNF, MIP-1 alpha, and MIP-1 beta) in vitro, and altered thermoregulation in vivo.

1995 • 152 citations

The state of ferriprotoporphyrin IX in malaria pigment.

1987 • 151 citations

Hemozoin-Inducible Proinflammatory Events In Vivo: Potential Role in Malaria Infection

2004 • 138 citations

Hemozoin Induces Macrophage Chemokine Expression through Oxidative Stress-Dependent and -Independent Mechanisms

2005 • 133 citations

Hemozoin Increases IFN-γ-Inducible Macrophage Nitric Oxide Generation Through Extracellular Signal-Regulated Kinase- and NF-κB-Dependent Pathways

2003 • 132 citations

NMR Structure of the Apoptosis- and Inflammation-Related NALP1 Pyrin Domain

2003 • 128 citations

Periodic and chaotic host-parasite interactions in human malaria.

1991 • 119 citations

Molecular Basis for a Direct Interaction between the Syk Protein-tyrosine Kinase and Phosphoinositide 3-Kinase

2004 • 115 citations

Short report: Positive correlation between rosetting and parasitemia in Plasmodium falciparum clinical isolates.

2002 • 90 citations

ITAM-based signaling beyond the adaptive immune response

2005 • 86 citations

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

2008 • 84 citations

Signal transduction pathways used by NLR-type innate immune receptors

2008 • 51 citations

Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase

2007 • 48 citations

The Exocytosis Regulator Synaptotagmin V Controls Phagocytosis in Macrophages

2008 • 43 citations

Lysosome is a primary organelle in B cell receptor‐mediated apoptosis: an indispensable role of Syk in lysosomal function

2004 • 36 citations

Lysosome is a primary organelle in B cell receptor-mediated apoptosis : an indispensable role of Syk in lysosomal function

2005 • 22 citations

Evidence for a Role for SAM68 in the Responses of Human Neutrophils to Ligation of CD32 and to Monosodium Urate Crystals

2001 • 21 citations