Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

Use and Abuse of HOMA Modeling

2004 • 4,678 citations

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

2003 • 3,886 citations

Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy

2006 • 2,850 citations

U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease

1995 • 1,880 citations

Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

2007 • 1,683 citations

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2002 • 946 citations

Diagnosis and Classification of Diabetes Mellitus

2006 • 898 citations

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

2007 • 734 citations

Effect of intensive insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial

2008 • 727 citations

The role of interleukin-1 in the pathogenesis of IDDM

1996 • 528 citations

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

1986 • 525 citations

IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1β genes

1998 • 435 citations

An immune origin of type 2 diabetes?

2005 • 391 citations

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

2008 • 313 citations

Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-1β in human islets

2004 • 244 citations

Gene Expression in Peripheral Blood Mononuclear Cells from Children with Diabetes

2007 • 202 citations

Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes

2008 • 199 citations

Inflammation, Insulin Resistance, and Diabetes—Mendelian Randomization Using CRP Haplotypes Points Upstream

2008 • 158 citations

Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels

2007 • 89 citations

Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible?

1995 • 77 citations

Monokine Antagonism Is Reduced in Patients With IDDM

1994 • 77 citations

Polymorphisms of the IL1-Receptor Antagonist Gene ( IL1RN ) Are Associated With Multiple Markers of Systemic Inflammation

2008 • 74 citations

Interleukin-1 Receptor Antagonist Genotype Is Associated With Coronary Atherosclerosis in Patients With Type 2 Diabetes

2002 • 69 citations

Effects of insulin vs. glibenclamide in recently diagnosed patients with type 2 diabetes: a 4‐year follow‐up

2007 • 58 citations

Interleukin-1 System Gene Polymorphisms Are Associated with Fat Mass in Young Men

2006 • 49 citations