Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

Autophagy as a Regulated Pathway of Cellular Degradation

2000 • 3,453 citations

The role of autophagy during the early neonatal starvation period

2004 • 2,753 citations

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

2008 • 1,992 citations

Role of autophagy in cancer

2007 • 1,712 citations

Inhibition of Macroautophagy Triggers Apoptosis

2005 • 1,581 citations

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

2008 • 1,543 citations

LC3 conjugation system in mammalian autophagy

2004 • 1,331 citations

Bafilomycin A1 Prevents Maturation of Autophagic Vacuoles by Inhibiting Fusion between Autophagosomes and Lysosomes in Rat Hepatoma Cell Line, H-4-II-E Cells.

1998 • 1,245 citations

Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling

2007 • 1,185 citations

Reactive species mechanisms of cellular hypoxia-reoxygenation injury

2002 • 1,014 citations

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

2008 • 973 citations

Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study

2005 • 908 citations

Autophagy suppresses tumor progression by limiting chromosomal instability

2007 • 893 citations

Autophagosome Formation in Mammalian Cells.

2002 • 845 citations

Hypoxia signalling through mTOR and the unfolded protein response in cancer

2008 • 837 citations

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

2007 • 805 citations

Autophagy in metazoans: cell survival in the land of plenty

2005 • 752 citations

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

1979 • 523 citations

The pleiotropic role of autophagy: from protein metabolism to bactericide

2005 • 465 citations

Intermittent blood flow in a murine tumor: radiobiological effects.

1987 • 440 citations

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

2007 • 429 citations

Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours

2008 • 164 citations

Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62

2008 • 149 citations

Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer

2006 • 133 citations

Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations

2006 • 116 citations

Glutathione Participates in the Regulation of Mitophagy in Yeast

2009 • 114 citations

Intermittent Hypoxia Furthers the Rationale for Hypoxia-Inducible Factor-1 Targeting

2007 • 105 citations

The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: A prospective international multi-center study

2006 • 102 citations

Targeting hypoxia tolerance in cancer

2004 • 91 citations

Temporal changes in pO2 of R3230Ac tumors in fischer-344 rats

1998 • 68 citations

Phosphorylation of eIF2α is required for mRNA translation inhibition and survival during moderate hypoxia

2007 • 56 citations

A critical role of superoxide anion in selenite-induced mitophagic cell death

2008 • 54 citations

Clinical Relevance of Intermittent Tumour Blood Flow

2001 • 53 citations