Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

Use and Abuse of HOMA Modeling

2004 • 4,678 citations

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

2003 • 3,886 citations

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

2002 • 946 citations

Diagnosis and Classification of Diabetes Mellitus

2006 • 898 citations

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

2006 • 882 citations

Radioimmunological determination of human C-peptide in serum

1975 • 844 citations

U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group

1995 • 762 citations

Enzyme immunoassay for intact human insulin in serum or plasma

1993 • 534 citations

The role of interleukin-1 in the pathogenesis of IDDM

1996 • 528 citations

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

1986 • 525 citations

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

2004 • 419 citations

The Role of the Interleukin-1–Receptor Antagonist in Blocking Inflammation Mediated by Interleukin-1

2000 • 372 citations

Glucose Induces β-Cell Apoptosis Via Upregulation of the Fas Receptor in Human Islets

2001 • 365 citations

Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins

2004 • 274 citations

Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-1β in human islets

2004 • 244 citations

Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins

2004 • 232 citations

Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice

2006 • 172 citations

INSULIN RESPONSE TO GLUCOSE INFUSION IN DIABETIC AND NON-DIABETIC MONOZYGOTIC TWIN PAIRS. GENETIC CONTROL OF INSULIN RESPONSE?

1967 • 150 citations

Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

2004 • 143 citations

Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?

2005 • 126 citations

The life story of the pancreatic B cell

1984 • 118 citations

Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice

2006 • 90 citations

Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM

1995 • 58 citations

ELISA for human proinsulin

1986 • 46 citations

Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats

1993 • 29 citations