IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

2004 • 1,663 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

2001 • 1,593 citations

Inflammatory Caspases

2004 • 917 citations

Spectrum of clinical features in Muckle‐Wells syndrome and response to anakinra

2004 • 746 citations

Chronic Infantile Neurological Cutaneous and Articular Syndrome Is Caused by Mutations in CIAS1, a Gene Highly Expressed in Polymorphonuclear Cells and Chondrocytes

2002 • 732 citations

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin‐associated autoinflammatory diseases

2002 • 693 citations

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

2004 • 568 citations

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

2004 • 547 citations

Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU

2003 • 464 citations

Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

2002 • 350 citations

Familial cold autoinflammatory syndrome: Phenotype and genotype of an autosomal dominant periodic fever

2001 • 315 citations

New Mutations of CIAS1 That Are Responsible for Muckle-Wells Syndrome and Familial Cold Urticaria: A Novel Mutation Underlies Both Syndromes

2002 • 294 citations

Cryopyrin-induced Interleukin 1β Secretion in Monocytic Cells

2004 • 233 citations

The autoinflammatory syndromes

2002 • 116 citations

Enhanced interleukin‐1β and interleukin‐18 release in a patient with chronic infantile neurologic, cutaneous, articular syndrome

2004 • 64 citations

Response to anakinra in a de novo case of neonatal‐onset multisystem inflammatory disease

2004 • 53 citations

A large kindred with familial cold autoinflammatory syndrome

2003 • 32 citations