Vitamin D

Osteoclast differentiation and activation

2003 • 6,172 citations

Prediction of bone density from vitamin D receptor alleles

1994 • 1,931 citations

Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis

2004 • 1,664 citations

1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system

2002 • 1,556 citations

Genetics and biology of vitamin D receptor polymorphisms

2004 • 1,481 citations

The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed

1998 • 1,391 citations

Minireview: The OPG/RANKL/RANK System

2001 • 1,385 citations

Unique Biosynthesis by Kidney of a Biologically Active Vitamin D Metabolite

1970 • 1,281 citations

1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation

2000 • 1,253 citations

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.

1981 • 1,025 citations

An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3

1999 • 989 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

1996 • 922 citations

Vitamin D in preventive medicine: are we ignoring the evidence?

2003 • 904 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus

1973 • 781 citations

1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.

1996 • 729 citations

RANK Is the Essential Signaling Receptor for Osteoclast Differentiation Factor in Osteoclastogenesis

1998 • 729 citations

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase

2004 • 695 citations

Vitamin D insufficiency among free-living healthy young adults

2002 • 677 citations

Control of 25-Hydroxycholecalciferol Metabolism by Parathyroid Glands

1972 • 661 citations

Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance

2001 • 627 citations

Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction

2001 • 623 citations

Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects

2001 • 579 citations

25-Hydroxyvitamin D ₃ 1α-Hydroxylase and Vitamin D Synthesis

1997 • 528 citations

Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice¹

1998 • 514 citations

Influence of the Vitamin D-binding Protein on the Serum Concentration of 1,25-Dihydroxyvitamin D3

1981 • 507 citations

Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

2003 • 476 citations

The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulatory agents

2002 • 469 citations

Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators

1999 • 442 citations

Role of Vitamin D in Skeletal Muscle Function*

1986 • 437 citations

SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues

2002 • 425 citations

FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa

2004 • 421 citations

A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer

2003 • 421 citations

Deletion of Vitamin D Receptor Gene in Mice Results in Abnormal Skeletal Muscle Development with Deregulated Expression of Myoregulatory Transcription Factors

2003 • 419 citations

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

1996 • 414 citations

A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases

2003 • 405 citations

Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene

2001 • 404 citations

Transcriptional Repression of the Interleukin-2 Gene by Vitamin D₃: Direct Inhibition of NFATp/AP-1 Complex Formation by a Nuclear Hormone Receptor

1995 • 399 citations

Cloning of Human 25-Hydroxyvitamin D-1α-Hydroxylase and Mutations Causing Vitamin D-Dependent Rickets Type 1

1997 • 398 citations

Human Calcium-sensing Receptor Gene

2002 • 396 citations

Inactivation of the 25-Hydroxyvitamin D 1α-Hydroxylase and Vitamin D Receptor Demonstrates Independent and Interdependent Effects of Calcium and Vitamin D on Skeletal and Mineral Homeostasis

2004 • 389 citations

Targeted Inactivation of the 25-Hydroxyvitamin D3-1α-Hydroxylase Gene (CYP27B1) Creates an Animal Model of Pseudovitamin D-Deficiency Rickets*

2001 • 385 citations

Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein

1999 • 381 citations

De-orphanization of Cytochrome P450 2R1

2003 • 376 citations

The Cutaneous Photosynthesis of Previtamin D3: A Unique Photoendocrine System

1981 • 374 citations

Genetics of Osteoporosis

1999 • 370 citations

Regulation of Serum 1α,25-Dihydroxyvitamin D ₃ by Calcium and Phosphate in the Rat

1975 • 369 citations

Inactivating Mutations in the 25-Hydroxyvitamin D₃1α-Hydroxylase Gene in Patients with Pseudovitamin D–Deficiency Rickets

1998 • 360 citations

Vitamin D regulation of the renin–angiotensin system

2003 • 358 citations

1,25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons

2003 • 350 citations

The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3in Vivo and in Vitro

2004 • 327 citations

Mechanisms of gene regulation by vitamin D3 receptor: a network of coactivator interactions

2000 • 321 citations

Deficient Mineralization of Intramembranous Bone in Vitamin D-24-Hydroxylase-Ablated Mice Is Due to Elevated 1,25-Dihydroxyvitamin D and Not to the Absence of 24,25-Dihydroxyvitamin D*

2000 • 321 citations

Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects

1997 • 320 citations

The 25-Hydroxyvitamin D 1-Alpha-Hydroxylase Gene Maps to the Pseudovitamin D-Deficiency Rickets (PDDR) Disease Locus

1997 • 318 citations

Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia.

1994 • 310 citations

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D ₃

2001 • 302 citations

Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent

2003 • 287 citations

The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer

2004 • 284 citations

Cloning of the human 1α,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements

1995 • 281 citations

The Polymorphism in the Caudal-Related Homeodomain Protein Cdx-2 Binding Element in the Human Vitamin D Receptor Gene

2001 • 280 citations

1α,25-Dihydroxycholecalciferol Receptors in Intestine

1974 • 279 citations

Molecular nature of the vitamin D receptor and its role in regulation of gene expression.

2001 • 279 citations

Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

2002 • 277 citations

Vitamin D: Metabolism and Biological Actions

1984 • 271 citations

Vitamin D Binding Protein (Gc-Globulin)*

1989 • 263 citations

Markedly Reduced Bile Acid Synthesis but Maintained Levels of Cholesterol and Vitamin D Metabolites in Mice with Disrupted Sterol 27-Hydroxylase Gene

1998 • 263 citations

Calcium Transport in Perfused Duodena from Normal Chicks: Enhancement within Fourteen Minutes of Exposure to 1,25-Dihydroxyvitamin D₃*

1984 • 262 citations

Calcitriol Controls the Epithelial Calcium Channel in Kidney

2001 • 257 citations

1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes.

1996 • 256 citations

Parathyroid hormone activation of the 25-hydroxyvitamin D ₃ -1α-hydroxylase gene promoter

1998 • 250 citations

Effect of 1,25(OH)2 vitamin D3 on glomerulosclerosis in subtotally nephrectomized rats

1998 • 248 citations

CCAAT/Enhancer-binding Proteins (C/EBP) β and δ Activate Osteocalcin Gene Transcription and Synergize with Runx2 at the C/EBP Element to Regulate Bone-specific Expression

2002 • 246 citations

The phosphatonin pathway: New insights in phosphate homeostasis

2003 • 246 citations

Effects of vitamin D3 metabolites on cytosolic free calcium in confluent mouse osteoblasts.

1987 • 246 citations

Mediation of Unusually High Concentrations of 1,25-Dihydroxyvitamin D in HomozygousklothoMutant Mice by Increased Expression of Renal 1α-Hydroxylase Gene

2002 • 239 citations

Regulation of 25-hydroxyvitamin D3-1α-hydroxylase and production of 1α,25-dihydroxyvitamin D3 by human dendritic cells

2003 • 239 citations

The noncalcemic analogue of vitamin D, 22-oxacalcitriol, suppresses parathyroid hormone synthesis and secretion.

1989 • 237 citations

Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.

1991 • 233 citations

Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene.

1994 • 231 citations

Studies on the Mode of Action of Calciferol. XIII. Development of a Radioimmunoassay for Vitamin DDependent Chick Intestinal Calcium-Binding Protein and Tissue Distribution*

1979 • 226 citations

Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligand-induced stabilization.

1992 • 224 citations

Rat calcium-sensing receptor is regulated by vitamin D but not by calcium

1996 • 224 citations

1,25-Dihydroxyvitamin D₃decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat

2004 • 221 citations

Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states

2004 • 221 citations

Identification of a Membrane Receptor for 1,25-Dihydroxyvitamin D3 Which Mediates Rapid Activation of Protein Kinase C

1998 • 218 citations

Ribozyme knockdown functionally links a 1,25(OH) ₂ D ₃ membrane binding protein (1,25D ₃ -MARRS) and phosphate uptake in intestinal cells

2004 • 216 citations

Calcium and Calpain as Key Mediators of Apoptosis-like Death Induced by Vitamin D Compounds in Breast Cancer Cells

2002 • 216 citations

Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

2003 • 215 citations

Vitamin D and barrier function: a novel role for extra-renal 1α-hydroxylase

2004 • 214 citations

Regulation of the hydroxylation of 25-hydroxyvitamin D3 in vivo and in primary cultures of chick kidney cells.

1979 • 213 citations

Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands

2004 • 205 citations

Intestinal calcium absorption: Molecular vitamin D mediated mechanisms

2003 • 203 citations

Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin

1977 • 201 citations

Cloning and expression of rat 25-hydroxyvitamin D ₃ -1α-hydroxylase cDNA

1997 • 196 citations

Vitamin D receptor genotypes in primary hyperparathyroidism

1995 • 195 citations

Cellular Mechanisms of Insulin Release: The Effects of Vitamin D Deficiency and Repletion on Rat Insulin Secretion*

1983 • 193 citations

The Promoter of the Human 25-Hydroxyvitamin D31α-Hydroxylase Gene Confers Positive and Negative Responsiveness to PTH, Calcitonin, and 1α,25(OH)2D3

1998 • 188 citations

Consequences of vitamin D receptor gene polymorphisms for growth inhibition of cultured human peripheral blood mononuclear cells by 1,25‐dihydroxyvitamin D₃

2000 • 185 citations

Regulation of Metabolism of 25-Hydroxycholecalciferol by Kidney Tissue in vitro by Dietary Calcium

1972 • 183 citations

Regulation of the epithelial Ca²⁺channels in small intestine as studied by quantitative mRNA detection

2003 • 182 citations

Demonstration that 1 beta,25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D3.

1993 • 182 citations

Stimulation of Osteoclast Formation by 1,25-Dihydroxyvitamin D Requires Its Binding to Vitamin D Receptor (VDR) in Osteoblastic Cells: Studies Using VDR Knockout Mice

1999 • 181 citations

Molecular Cloning of cDNA and Genomic DNA for Human 25-hydroxyvitamin D31α-hydroxylase

1997 • 180 citations

Prevalence of Vitamin D Insufficiency in Canada and the United States: Importance to Health Status and Efficacy of Current Food Fortification and Dietary Supplement Use

2003 • 178 citations

The Caudal-Related Homeodomain Protein Cdx-2 Regulates Vitamin D Receptor Gene Expression in the Small Intestine

1999 • 174 citations

p21WAF1 and TGF-α mediate parathyroid growth arrest by vitamin D and high calcium

2001 • 172 citations

Calnexin, Calreticulin, and ERp57: Teammates in Glycoprotein Folding

2003 • 172 citations

Rapid modulation of osteoblast ion channel responses by 1α,25(OH) ₂ -vitamin D ₃ requires the presence of a functional vitamin D nuclear receptor

2004 • 153 citations

CYP3A4 is a Human Microsomal Vitamin D 25-Hydroxylase

2004 • 150 citations

Regulation of the metabolism of 25-hydroxyvitamin D3 in primary cultures of chick kidney cells.

1979 • 144 citations

Vitamin D₃ supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter

2003 • 144 citations

Differential effects of 19-nor-1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 on intestinal calcium and phosphate transport

2002 • 144 citations

Nuclear Coactivator-62 kDa/Ski-interacting Protein Is a Nuclear Matrix-associated Coactivator That May Couple Vitamin D Receptor-mediated Transcription and RNA Splicing

2003 • 143 citations

Inhibition of calcitriol receptor binding to vitamin D response elements by uremic toxins.

1995 • 141 citations

Accelerated Mammary Gland Development during Pregnancy and Delayed Postlactational Involution in Vitamin D3 Receptor Null Mice

2004 • 141 citations

Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells

2004 • 141 citations

On the Mechanisms for the Selective Action of Vitamin D Analogs*

1991 • 139 citations

p27Kip1 Stabilization and G1 Arrest by 1,25-Dihydroxyvitamin D3 in Ovarian Cancer Cells Mediated through Down-regulation of Cyclin E/Cyclin-dependent Kinase 2 and Skp1-Cullin-F-box Protein/Skp2 Ubiquitin Ligase

2004 • 138 citations

Free, and Not Total, 1,25-Dihydroxyvitamin D Regulates 25-Hydroxyvitamin D Metabolism by Keratinocytes

1989 • 138 citations

Stat1-Vitamin D Receptor Interactions Antagonize 1,25-Dihydroxyvitamin D Transcriptional Activity and Enhance Stat1-Mediated Transcription

2002 • 135 citations

A Functional Cell Surface Type Receptor Is Required for the Early Action of 1,25-Dihydroxyvitamin D3 on the Phosphoinositide Metabolism in Rat Enterocytes

1989 • 134 citations

Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats

2004 • 134 citations

Structural basis of VDR-DNA interactions on direct repeat response elements

2002 • 132 citations

Cdx-2 Polymorphism in the Promoter Region of the Human Vitamin D Receptor Gene Determines Susceptibility to Fracture in the Elderly

2003 • 131 citations

Vitamin D

1999 • 130 citations

Vitamin D3—implications for brain development

2004 • 129 citations

Stimulation of Phosphorylation of Mitogen-Activated Protein Kinase by 1α,25-Dihydroxyvitamin D3 in Promyelocytic NB4 Leukemia Cells: A Structure-Function Study*

1998 • 126 citations

PROLONGATION OF ALLOGRAFT SURVIVAL BY 1,25-DIHYDROXYVITAMIN D31

1998 • 121 citations

1,25-Dihydroxyvitamin D Down-regulates Cell Membrane Growth- and Nuclear Growth-promoting Signals by the Epidermal Growth Factor Receptor

2002 • 121 citations

Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3

1993 • 118 citations

Subcellular Distribution of Normal and Mutant Vitamin D Receptors in Living Cells

1997 • 118 citations

Stable expression of the nuclear vitamin D receptor in the human prostatic carcinoma cell line JCA-1: evidence that the antiproliferative effects of 1 alpha, 25-dihydroxyvitamin D3 are mediated exclusively through the genomic signaling pathway.

1996 • 117 citations

C/EBPβGene Inactivation Causes Both Impaired and Enhanced Gene Expression and Inverse Regulation of IL-12 p40 and p35 mRNAs in Macrophages

2002 • 115 citations

Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR

1998 • 114 citations

Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice

2002 • 113 citations

Pancreatic cancer cells express 25-hydroxyvitamin D-1 -hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3

2004 • 113 citations

Homologous up-regulation of the 1,25 (OH)2 vitamin D3 receptor in rats

1986 • 113 citations

Hormone-dependent Translocation of Vitamin D Receptors Is Linked to Transactivation

1999 • 112 citations

Toward a comprehensive molecular model of active calcium reabsorption

2000 • 111 citations

The vitamin D receptor is necessary for 1α,25-dihydroxyvitamin D3 to suppress experimental autoimmune encephalomyelitis in mice

2002 • 111 citations

p21WAF1 and transforming growth factor-α mediate dietary phosphate regulation of parathyroid cell growth

2001 • 110 citations

Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with advanced secondary hyperparathyroidism11See Editorial by Dusso on p. 1472.

2002 • 109 citations

The roles of calcium and 1,25-dihydroxyvitamin D3 in the regulation of vitamin D receptor expression by rat parathyroid glands.

1995 • 105 citations

Nongenomic regulation of protein kinase C isoforms by the vitamin D metabolites 1α,25-(OH)2D3 and 24R,25-(OH)2D3

1996 • 104 citations

CCAAT/enhancer binding proteins in normal mammary development and breast cancer

2002 • 104 citations

Protein Kinase C and Mitogen-activated Protein Kinase Are Required for 1,25-Dihydroxyvitamin D3-stimulated Egr Induction

1995 • 104 citations

Gene expression analysis suggests that 1,25-dihydroxyvitamin D₃reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis

2004 • 103 citations

Receptor-Associated Protein Is Important for Normal Processing of Megalin in Kidney Proximal Tubules

2000 • 103 citations

Tissue resistance to 1,25‐dihydroxyvitamin D without a mutation of the vitamin D receptor gene

1993 • 102 citations

Calcium as a mediator of 1,25-dihydroxyvitamin D3-induced apoptosis

2004 • 100 citations

The mechanism for the disparate actions of calcitriol and 22-oxacalcitriol in the intestine.

1993 • 98 citations

1,25-Dihydroxyvitamin D3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats

1996 • 96 citations

Regulation of gp330/megalin expression by vitamins A and D

1998 • 95 citations

Retinoblastoma Protein and CCAAT/Enhancer-Binding Protein β Are Required for 1,25-Dihydroxyvitamin D3-Induced Monocytic Differentiation of HL60 Cells

2004 • 93 citations

Stabilization of the vitamin D receptor in rat osteosarcoma cells through the action of 1,25-dihydroxyvitamin D3.

1993 • 93 citations

1?,25-Dihydroxy-3-Epi-vitamin D3, a natural metabolite of 1?,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone secretion

1999 • 93 citations

Rapid Effects of 1,25-Dihydroxyvitamin D₃and Extracellular Ca²⁺on Phospholipid Metabolism in Dispersed Porcine Parathyroid Cells

1990 • 92 citations

Annexin II is the membrane receptor that mediates the rapid actions of 1?,25-dihydroxyvitamin D3

2000 • 90 citations

Two novel 1α-hydroxylase mutations in French-Canadians with vitamin D dependency rickets type I

1998 • 86 citations

Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized rats

2003 • 85 citations

Steroid Hormone Interactions with Target Cells: Cross Talk between Membrane and Nuclear Pathways: Fig. 1.

2003 • 85 citations

Induction of common mucosal immunity by hormonally immunomodulated peripheral immunization

1996 • 84 citations

Differentiation-Related Pathways of 1α,25-Dihydroxycholecalciferol Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells: Production of 1α,25-Dihydroxy-3epi-cholecalciferol

1998 • 78 citations

In Vitro Stimulation of 25-Hydroxycholecalciferol lα- Hydroxylation by Parathyroid Hormone in Chick Kidney Slices: Evidence for a Role for Adenosine 3′,5′- Monophosphate *

1981 • 78 citations

Epidermal Growth Factor Receptor Stimulation Activates the RNA Binding Protein CUG-BP1 and Increases Expression of C/EBPβ-LIP in Mammary Epithelial Cells

2004 • 76 citations

1,25-dihydroxyvitamin D3-induced apoptosis of retinoblastoma cells is associated with reciprocal changes of Bcl-2 and bax

2003 • 75 citations

1,25-Dihydroxyvitamin D3 analog structure-function assessment of the rapid stimulation of intestinal calcium absorption (transcaltachia)

1992 • 74 citations

Schizophrenia, vitamin D, and brain development

2004 • 74 citations

Rapid and genomic biological responses are mediated by different shapes of the agonist steroid hormone, 1α,25(oh)2vitamin d3

1999 • 73 citations

1α,25 Dihydroxyvitamin D3 Rapidly Regulates the Mouse Osteoprotegerin Gene Through Dual Pathways

2004 • 73 citations

An equilibrium and kinetic study of 1,25-dihydroxyvitamin D3 binding to chicken intestinal cytosol employing high specific activity 1,25-dihydroxy[3H-26, 27]vitamin D3

1979 • 70 citations

1,25-(OH2)D3 Alters the Transforming Growth Factor β Signaling Pathway in Renal Tissue

2001 • 66 citations

1,25-Dihydroxyvitamin D3 increases striatal GDNF mRNA and protein expression in adult rats

2002 • 64 citations

Biological actions and mechanism of action of calbindin in the process of apoptosis

2004 • 64 citations

Vitamin D receptor and analogs

2004 • 64 citations

Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1α-hydroxylase knockout mice

2004 • 64 citations

Vitamin D3 accelerates PTH-dependent calcium transport in distal convoluted tubule cells

1993 • 62 citations

The Vitamin D Receptor--Structure and Transcriptional Activation

1997 • 61 citations

Nongenomic regulation of extracellular matrix events by vitamin D metabolites

1994 • 61 citations

Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo

2003 • 60 citations

Metabolic pathways from 1 alpha,25-dihydroxyvitamin D3 to 1 alpha,25-dihydroxyvitamin D3-26,23-lactone. Stereo-retained and stereo-selective lactonization.

1987 • 60 citations

Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300

2004 • 57 citations

Effect of 1,25-dihydroxyvitamin D3 on cytosolic calcium in dispersed parathyroid cells

1988 • 57 citations

Percutaneous maxacalcitol injection therapy regresses hyperplasia of parathyroid and induces apoptosis in uremia

2003 • 56 citations

Subcellular localization of vitamin D3 25-hydroxylase in human liver.

1984 • 56 citations

Molybdate increases intracellular 3‘,5‘-guanosine cyclic monophosphate and stabilizes vitamin D receptor association with tubulin-containing filaments.

1992 • 55 citations

The Functional Consequences of Cross-talk between the Vitamin D Receptor and ERK Signaling Pathways Are Cell-specific

2004 • 54 citations

Functional interaction of megalin with the megalinbinding protein(MegBP), a novel tetratrico peptide repeat-containing adaptor molecule

2002 • 54 citations

1,25(OH)2D3 suppresses expression and secretion of atrial natriuretic peptide from cardiac myocytes

1995 • 53 citations

Depressed Natural Killer Cell Activity in Uremia

1988 • 52 citations

Normocalcemia without hyperparathyroidism in vitamin D-deficient rats

1991 • 51 citations

Antiapoptotic action of 1α,25-dihydroxyvitamin D3 in primary human melanocytes

2003 • 50 citations

Nongenomic actions of the steroid hormone 1α25‐dihydroxyvitamin D₃

1994 • 50 citations

Vitamin D Protects Keratinocytes from Apoptosis Induced by Osmotic Shock, Oxidative Stress, and Tumor Necrosis Factor

2003 • 49 citations

Photochemical conversion of 7-dehydrocholesterol into vitamin D3 in rat skins.

1977 • 49 citations

Mechanism of action of superactive vitamin D analogs through regulated receptor degradation

2000 • 49 citations

Analysis of Binding of the 1,25-Dihydroxyvitamin D3Receptor to Positive and Negative Vitamin D Response Elements

1996 • 48 citations

Regulation of Extrarenal Vitamin D Metabolism as a Tool for Colon and Prostate Cancer Prevention

2003 • 47 citations

1α-Hydroxylase transactivation by γ-interferon in murine macrophages requires enhanced C/EBPβ expression and activation

2004 • 46 citations

Calreticulin Inhibits Vitamin D's Action on the PTH Gene in Vitro and May Prevent Vitamin D's Effect in Vivo in Hypocalcemic Rats

1998 • 46 citations

Functional Characterization of a Novel Type of 1α,25-Dihydroxyvitamin D3Response Element Identified in the Mouse c-fosPromoter

1997 • 45 citations

Targeting 1α,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors

2004 • 44 citations

1α,25(OH)2Vitamin D3-Mediated Stimulation of Outward Anionic Currents in Osteoblast-like ROS 17/2.8 Cells

1996 • 43 citations

Ca2+ priming during vitamin D-induced monocytic differentiation of a human leukemia cell line.

1988 • 43 citations

Mechanism of stimulation of renal phosphate transport by 1,25-dihydroxycholecalciferol

1985 • 42 citations

Expression of the renal 25-hydroxyvitamin D-24-hydroxylase gene: regulation by dietary phosphate

1996 • 41 citations

Differential activities of 1α,25-dihydroxy-16-ene-vitamin D3 analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis

2001 • 41 citations

Microtubules Mediate Cellular 25-Hydroxyvitamin D3 Trafficking and the Genomic Response to 1,25-Dihydroxyvitamin D3 in Normal Human Monocytes

1995 • 41 citations

The rapid nongenomic actions of 1α,25‐dihydroxyvitamin D₃ modulate the hormone‐induced increments in osteocalcin gene transcription in osteoblast‐like cells

1992 • 40 citations

Ligand-mediated conformational changes of the VDR are required for gene transactivation

2004 • 40 citations

A 20-epi side chain restores growth-regulatory and transcriptional activities of an A ring-modified hybrid analog of 1α,25-dihydroxyvitamin D3 without increasing its affinity to the vitamin D receptor

1996 • 38 citations

Induction of Apoptosis by Vitamin D Metabolites and Analogs in a Glioma Cell Line

2003 • 38 citations

Target gene activation by 1,25-dihydroxyvitamin D3 in osteosarcoma cells is independent of calcium influx.

1994 • 37 citations

22-Oxacalcitriol: dissection of 1,25(OH)2D3 receptor-mediated and Ca2+ entry-stimulating pathways

1993 • 35 citations

Glucose-Induced Insulin Secretion in Uremia: Role of 1α,25(HO)<sub>2</sub>-Vitamin D<sub>3</sub>

1994 • 34 citations

The genes of the coactivator TIF2 and the corepressor SMRT are primary 1α,25(OH)2D3 targets

2004 • 34 citations

The 1,25-dihydroxyvitamin D3 receptor is phosphorylated in response to 1,25-dihydroxyvitamin D3 and 22-oxacalcitriol in rat osteoblasts, and by casein kinase II, in vitro

1993 • 34 citations

Effect of Calcitriol on Insulin Secretion in Uraemia

1990 • 34 citations

Control of 1,25-dihydroxyvitamin D3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine.

1995 • 33 citations

Breast cancer cell regulation by high-dose Vitamin D compounds in the absence of nuclear Vitamin D receptor

2004 • 32 citations

RETRACTED: Vitamin D receptor (VDR) promoter targeting through a novel chromatin remodeling complex

2004 • 30 citations

Rapid stimulation of calcium uptake by isolated rat enterocytes by 1,25(OH)2D3

1989 • 29 citations

Sex-Related Difference in Vitamin D3 25-Hydroxylase of Rat Liver Microsomes1

1988 • 28 citations

Evidence that annexin II Is not a putative membrane receptor for 1α,25(OH)₂‐vitamin D₃

2004 • 26 citations

The role of cytokines in skeletal remodelling: possible consequences for renal osteodystrophy

2000 • 26 citations

Glucose-induced insulin secretion in uremia: Effects of aminophylline infusion and glucose loads

1990 • 25 citations

Effect of rabbit duodenal mRNA on phosphate transport in Xenopus laevis oocytes: dependence on 1,25-dihydroxy-vitamin-D3

1992 • 24 citations

1α,25-DihydroxyvitaminD₃[1α,25-(OH)2D₃]-26,23 Lactone Inhibits 1,25-(OH)2D₃-Mediated Fusion of Mouse Bone Marrow Mononuclear Cells

1988 • 23 citations

Early rise in cyclic GMP after 1,25-dihydroxycholecalciferol administration in the chick intestinal mucosa

1980 • 21 citations

Cation-dependent vitamin D activation of human renal cortical guanylate cyclase

1984 • 21 citations

Elevated Ca2+ does not inhibit the 1,25(OH)2D3 response to phosphorus restriction

1989 • 20 citations

In Vivo Dose-related Receptor Binding of the Vitamin D Analogue [³H]-1,25-dihydroxy-22-oxavitamin D₃ (OCT) in Rat Parathyroid, Kidney Distal and Proximal Tubules, Duodenum, and Skin, Studied by Quantitative Receptor Autoradiography

1998 • 20 citations

Proteins in the Heat Shock-70 Family Specifically Bind 25-Hydroxyvitamin D3 and 17 -Estradiol

1998 • 19 citations

1 alpha,25(OH)2-vitamin D3 analog structure-function assessment of intestinal nuclear receptor occupancy with induction of calbindin-D28K.

1995 • 18 citations

Effect of Schiff base formation on the function of the calcitriol receptor

1996 • 17 citations

Effects of calcitriol and its analogues, calcipotriol (MC 903) and 20-Epi-1α,25-dihydroxyvitamin D3 (MC 1288), on calcium influx and DNA synthesis in cultured muscle cells

1997 • 15 citations

Modulation of the excitability of avian peripheral nerves by vitamin D: relation to calbindin-D28k, calcium status and lipid composition

1994 • 15 citations

A combined treatment with 1α,25-dihydroxy-vitamin D3 and 17β-estradiol reduces the expression of heat shock protein-32 (HSP-32) following cerebral cortical ischemia

2004 • 14 citations

Identification of HRPAP20

2004 • 11 citations

Reply

2000 • 1 citations