The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3in Vivo and in Vitro

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Structure-Function Relationships in the Vitamin D Endocrine System*

1995 • 1,182 citations

Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

1997 • 1,149 citations

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors

2001 • 1,123 citations

The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand

2000 • 802 citations

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

2003 • 787 citations

A detergent-free method for purifying caveolae membrane from tissue culture cells.

1995 • 732 citations

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity

2001 • 661 citations

Multiple Functions of Caveolin-1

2002 • 579 citations

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

2004 • 556 citations

Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells

2003 • 442 citations

Linkage of Rapid Estrogen Action to MAPK Activation by ERα-Shc Association and Shc Pathway Activation

2002 • 403 citations

ERs Associate with and Regulate the Production of Caveolin: Implications for Signaling and Cellular Actions

2002 • 380 citations

Identification of a Structural Determinant Necessary for the Localization and Function of Estrogen Receptor α at the Plasma Membrane

2003 • 317 citations

Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia.

1994 • 310 citations

Vitamin D: More Than a “Bone-a-Fide” Hormone

2003 • 295 citations

Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

2002 • 277 citations

Structure-function relationships in the vitamin D endocrine system

1995 • 268 citations

ERβ Has Nongenomic Action in Caveolae

2002 • 265 citations

Calcium Transport in Perfused Duodena from Normal Chicks: Enhancement within Fourteen Minutes of Exposure to 1,25-Dihydroxyvitamin D₃*

1984 • 262 citations

Testosterone Stimulates Intracellular Calcium Release and Mitogen-Activated Protein Kinases Via a G Protein-Coupled Receptor in Skeletal Muscle Cells

2003 • 250 citations

Multiple promoters direct the tissue-specific expression of novel N-terminal variant human vitamin D receptor gene transcripts

1998 • 200 citations

An hydroxylapatite batch assay for the quantitation of 1α,25-dihydroxyvitamin D3-receptor complexes

1979 • 196 citations

Biological Activity of the Vitamin D Metabolite 1,25-Dihydroxycholecalciferol in Chickens and Rats

1972 • 190 citations

1α,25-Dihydroxyvitamin D ₃ Induces Vascular Smooth Muscle Cell Migration via Activation of Phosphatidylinositol 3-Kinase

2002 • 161 citations

Unoccupied 1,25-dihydroxyvitamin D3 receptors. Nuclear/cytosol ratio depends on ionic strength.

1980 • 161 citations

The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors, which increase PSA secretion and modify actin cytoskeleton

2002 • 160 citations

Rapid modulation of osteoblast ion channel responses by 1α,25(OH) ₂ -vitamin D ₃ requires the presence of a functional vitamin D nuclear receptor

2004 • 153 citations

A structural basis for the unique binding features of the human vitamin D-binding protein

2002 • 145 citations

Stimulation of Phosphorylation of Mitogen-Activated Protein Kinase by 1α,25-Dihydroxyvitamin D3 in Promyelocytic NB4 Leukemia Cells: A Structure-Function Study*

1998 • 126 citations

Direct Activation of Protein Kinase C by 1α,25-Dihydroxyvitamin D3

1995 • 125 citations

1,25(OH)₂‐vitamin D₃ induces translocation of the vitamin D receptor (VDR) to the plasma membrane in skeletal muscle cells

2002 • 123 citations

Receptors for 1α,25(OH)2D3: Past, Present, and Future

1998 • 123 citations

Comparison of 6-s-cis- and 6-s-trans-Locked Analogs of 1α,25-Dihydroxyvitamin D3 Indicates That the 6-s-cis Conformation Is Preferred for Rapid Nongenomic Biological Responses and That Neither 6-s-cis- nor 6-s-trans-Locked Analogs Are Preferred for Genomic Biological Responses

1997 • 121 citations

Subcellular Distribution of Normal and Mutant Vitamin D Receptors in Living Cells

1997 • 118 citations

Immunoisolation of Caveolae with High Affinity Antibody Binding to the Oligomeric Caveolin Cage

1999 • 116 citations

An Insulinotropic Effect of Vitamin D Analog with Increasing Intracellular Ca2+ Concentration in Pancreatic β-Cells through Nongenomic Signal Transduction1

1999 • 111 citations

Selective Modulation of Genomic and Nongenomic Androgen Responses by Androgen Receptor Ligands

2003 • 107 citations

Protein Kinase C and Mitogen-activated Protein Kinase Are Required for 1,25-Dihydroxyvitamin D3-stimulated Egr Induction

1995 • 104 citations

Stimulation by 1α,25(OH)2-Vitamin D3 of Whole Cell Chloride Currents in Osteoblastic ROS 17/2.8 Cells

1997 • 100 citations

Physiological Importance of the 1,25(OH)2D3 Membrane Receptor and Evidence for a Membrane Receptor Specific for 24,25(OH)2D3

1999 • 97 citations

1,25-Dihydroxyvitamin D3-mediated intestinal calcium transport. Biochemical identification of lysosomes containing calcium and calcium-binding protein (calbindin-D28K).

1986 • 97 citations

Activation of Raf—Mitogen–Activated Protein Kinase Signaling Pathway by 1,25-Dihydroxyvitamin D3 in Normal Human Keratinocytes

1996 • 95 citations

Rapid activation of endothelial NO synthase by estrogen: evidence for a steroid receptor fast-action complex (SRFC) in caveolae

2002 • 91 citations

Evidence that estrogens modulate activity and increase the number of 1,25-dihydroxyvitamin D receptors in osteoblast-like cells (ROS 17/2.8).

1992 • 85 citations

Activation of RAF-1 through Ras and Protein Kinase Cα Mediates 1α,25(OH)2-Vitamin D3 Regulation of the Mitogen-activated Protein Kinase Pathway in Muscle Cells

2003 • 82 citations

Molecular tools for study of genomic and rapid signal transduction responses initiated by 1α,25(OH)2-vitamin D3

2002 • 80 citations

1α,25-Dihydroxyvitamin D3 and 24R,25-Dihydroxyvitamin D3 Modulate Growth Plate Chondrocyte Physiology via Protein Kinase C-Dependent Phosphorylation of Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase

2002 • 80 citations

Novel N-Terminal Variant of Human VDR

2001 • 76 citations

Effect of Vitamin D Status on the Equilibrium between Occupied and Unoccupied 1,25-Dihydroxyvitamin D Intestinal Receptors in the Chick

1982 • 75 citations

1,25-Dihydroxyvitamin D3 Stimulates Expression and Translocation of Protein Kinase Cα and Cδ via a Nongenomic Mechanism and Rapidly Induces Phosphorylation of a 33-kDa Protein in Acute Promyelocytic NB4 Cells

1996 • 69 citations

Immunochemical studies on the putative plasmalemmal receptor for 1,25(OH)₂D₃. I. Chick intestine

2000 • 67 citations

Association of 1 alpha,25-dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane acceptance sites.

1996 • 64 citations

Rapid 1,25(OH)2-vitamin D3 stimulation of calcium uptake by rat intestinal cells involves a dihydropyridine-sensitive cAMP-dependent pathway

1994 • 61 citations

The Rapid Effects of 1,25-Dihydroxyvitamin D3 Require the Vitamin D Receptor and Influence 24-Hydroxylase Activity

2004 • 60 citations

A specific binding protein/receptor for 1α,25-dihydroxyvitamin D3 is present in an intestinal caveolae membrane fraction

2002 • 57 citations

Rapid effects of 1,25(OH)2 vitamin D3 on signal transduction systems in colonic cells

1999 • 50 citations

1α,25(OH)2D3 Regulates Chondrocyte Matrix Vesicle Protein Kinase C (PKC) Directly via G-protein-dependent Mechanisms and Indirectly via Incorporation of PKC during Matrix Vesicle Biogenesis

2002 • 42 citations

Time Course Study of Insulin Secretion after 1,25–Dihydroxyvitamin D₃Administration*

1985 • 40 citations

Cloning and Origin of the Two Forms of Chicken Vitamin D Receptor

1997 • 37 citations

Studies on the mode of action of calciferol XIX. A 24R-hydroxyl-group can replace the 25-hydroxyl-group of 1α,25-dihydroxyvitamin D3 for optimal binding to the chick intestinal receptor

1979 • 35 citations

Multiple molecular mechanisms of 1α,25(oh)2-vitamin D3 rapid modulation of three ion channel activities in osteoblasts

2003 • 33 citations

Binding of 1α,25‐dihydroxyvitamin D ₃ to annexin II: Effect of vitamin D metabolites and calcium

2000 • 30 citations

Evidence that annexin II Is not a putative membrane receptor for 1α,25(OH)₂‐vitamin D₃

2004 • 26 citations

Biochemical characterization of positive cooperativity in the binding of 1 alpha, 25-dihydroxyvitamin D3 to its chick intestinal chromatin receptor.

1985 • 22 citations

Binding of 1?,25-dihydroxyvitamin D3 to annexin II: Effect of vitamin D metabolites and calcium

2000 • 22 citations

Two Key Proteins of the Vitamin D Endocrine System Come Into Crystal Clear Focus: Comparison of the X-ray Structures of the Nuclear Receptor for 1α,25(OH)2 Vitamin D3, the Plasma Vitamin D Binding Protein, and Their Ligands

2003 • 21 citations

Differences in the accessibility of the β-adrenergic receptor in isolated hepatocytes from foetal and adult rats

1991 • 18 citations