Differentiation-Related Pathways of 1α,25-Dihydroxycholecalciferol Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells: Production of 1α,25-Dihydroxy-3epi-cholecalciferol

Vitamin D

1979 • 3,814 citations

Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture

1983 • 1,765 citations

Newly Identified Actions of the Vitamin D Endocrine System*

1992 • 563 citations

Suppression of in vivo growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3.

1987 • 312 citations

Calcitroic acid, end product of renal metabolism of 1,25-dihydroxyvitamin D3 through the C-24 oxidation pathway

1989 • 245 citations

Demonstration that 1 beta,25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D3.

1993 • 182 citations

Vitamin D, a pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications

1994 • 176 citations

Human prostate cancer cells: inhibition of proliferation by vitamin D analogs.

1994 • 153 citations

Vitamin D metabolism in human colon adenocarcinoma-derived Caco-2 cells: Expression of 25-hydroxyvitamin D3-1α-hydroxylase activity and regulation of sidechain metabolism

1997 • 122 citations

BRIEF COMMUNICATION: Growth Control of Human Colon Cancer Cells by Vitamin D and Calcium In Vitro

1992 • 101 citations

Regulation of vitamin D receptor abundance and responsiveness during differentiation of HT-29 human colon cancer cells.

1993 • 93 citations

Side-chain hydroxylation of vitamin D3 and its physiological implications

1987 • 70 citations

Isolation and identification 1,23-dihydroxy-24,25,26,27-tetranorvitamin D3, a new metabolite of 1,25-dihydroxyvitamin D3 produced in rat kidney

1987 • 68 citations

Antiproliferative effect of 1,25-dihydroxyvitamin D3 and its analogs on human colon adenocarcinoma cells (CaCo-2): Influence of extracellular calcium

1991 • 62 citations

1,25-Dihydroxy-24-OXO-16ene-vitamin D3, a renal metabolite of the vitamin D analog 1,25-dihydroxy-16ene-vitamin D3, exerts immunosuppressive activity equal to its parent without causing hypercalcemia in vivo.

1994 • 60 citations

C(24)- and C(23)-oxidation, converging pathways of intestinal 1,25-dihydroxyvitamin D3 metabolism: identification of 24-keto-1,23,25-trihydroxyvitamin D3

1983 • 52 citations

Expression of 25-Hydroxyvitamin D₃-24-Hydroxylase Activity in Caco-2 Cells, Anin VitroModel of Intestinal Vitamin D Catabolism*

1990 • 50 citations

The isolation and identification of two new metabolites of 25-hydroxyvitamin D3 produced in the kidney.

1983 • 45 citations

1α,25-dihydroxy-24-oxo-16-ene vitamin D3, a metabolite of a synthetic vitamin D3 analog, 1α,25-dihydroxy-16-ene vitamin D3, is equipotent to its parent in modulating growth and differentiation of human leukemic cells

1996 • 34 citations

Human osteoblasts in culture metabolize both 1 alpha, 25-dihydroxyvitamin D3 and its precursor 25-hydroxyvitamin D3 into their respective lactones.

1995 • 34 citations

The antiproliferative effect of vitamin D analogs on MCF-7 human breast cancer cells

1995 • 32 citations

Growth inhibition of human colon adenocarcinoma-derived Caco-2 cells by 1,25-dihydroxyvitamin D3 and two synthetic analogs: relation to in vitro hypercalcemic potential

1993 • 27 citations

Synthesis, Stereochemistry, and Biological Activity of 1α,23,25-Trihydroxy-24-oxovitamin D₃, a Major Natural Metabolite of 1α,25-Dihydroxyvitamin D₃

1997 • 24 citations

Selective biological response by target organs (intestine, kidney, and bone) to 1,25-dihydroxyvitamin D3 and two analogues.

1993 • 24 citations

Growth inhibitory effects on human colon adenocarcinoma-derived Caco-2 cells and calcemic potential of 1 alpha,25-dihydroxyvitamin D3 analogs: structure-function relationships.

1995 • 21 citations