Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

1997 • 3,518 citations

Current Understanding of the Molecular Actions of Vitamin D

1998 • 1,259 citations

Control of 25-Hydroxycholecalciferol Metabolism by Parathyroid Glands

1972 • 661 citations

Identification of the HumanKlothoGene and Its Two Transcripts Encoding Membrane and SecretedKlothoProtein

1998 • 624 citations

Regulation of 25-Hydroxycholecalciferol-1-Hydroxylase Activity in Kidney by Parathyroid Hormone

1973 • 525 citations

Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3

2000 • 376 citations

Positive and Negative Regulations of the Renal 25-Hydroxyvitamin D3 1α-Hydroxylase Gene by Parathyroid Hormone, Calcitonin, and 1α,25(OH)2D3 in Intact Animals*

1999 • 291 citations

Mediation of Unusually High Concentrations of 1,25-Dihydroxyvitamin D in HomozygousklothoMutant Mice by Increased Expression of Renal 1α-Hydroxylase Gene

2002 • 239 citations

Regulation of the hydroxylation of 25-hydroxyvitamin D3 in vivo and in primary cultures of chick kidney cells.

1979 • 213 citations

1alpha-Hydroxylase and the action of vitamin D

2000 • 210 citations

Human perinatal vitamin D metabolism I: 25-Hydroxyvitamin D in maternal and cord blood

1974 • 207 citations

Expression of 25-Hydroxyvitamin D3-1α-Hydroxylase in the Human Kidney

1999 • 183 citations

Localization of 25-hydroxyvitamin D3 1 alpha-hydroxylase and 24-hydroxylase along the rat nephron.

1981 • 180 citations

The Progression of Aging in Klotho Mutant Mice Can Be Modified by Dietary Phosphorus and Zinc

2001 • 159 citations

Calcitonin selectively stimulates 25-hydroxyvitamin D3-1α-hydroxylase in proximal straight tubule of rat kidney

1981 • 157 citations

Regulation of 25-Hydroxyvitamin D3 1α-Hydroxylase Gene Expression by Parathyroid Hormone and 1,25-Dihydroxyvitamin D3

2000 • 152 citations

Molecular Cloning of RatklothocDNA: Markedly Decreased Expression ofklothoby Acute Inflammatory Stress

1998 • 143 citations

Calcitonin is a major regulator for the expression of renal 25-hydroxyvitamin D ₃ -1α-hydroxylase gene in normocalcemic rats

1999 • 139 citations

Insulin-like growth factor-I regulation of renal 25-hydroxyvitamin D-1-hydroxylase activity.

1993 • 111 citations

Salt-Sensitive Hypertension in Transgenic Mice Overexpressing Na ⁺ -Proton Exchanger

1995 • 89 citations

Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene locus mutation that leads to a syndrome resembling aging

1998 • 49 citations

Regulation by Calcitonin and Glucocorticoids of Calcitonin Receptor Gene Expression in Mouse Osteoclasts¹

1997 • 49 citations

Normal Intrauterine Development of the Fetus of a Woman Receiving Extraordinarily High Doses of 1,25-Dihydroxyvitamin D₃*

1980 • 48 citations

25-Hydroxyvitamin D levels in patients treated with high-dosage ergo- and cholecalciferol.

1977 • 45 citations

Vitamin D status regulates 25-hydroxyvitamin D3-1 alpha-hydroxylase and its responsiveness to parathyroid hormone in the chick.

1985 • 43 citations

1-Hydroxylase and the action of vitamin D

2000 • 42 citations

Requirements and upper limits of vitamin D intake in the term neonate, infant, and older child

1990 • 28 citations

Elevated serum 1,25-dihydroxyvitamin D concentrations in the hypercalcemia of sarcoidosis: Correction by glucocorticoid therapy

1981 • 25 citations