Targeted Inactivation of the 25-Hydroxyvitamin D3-1α-Hydroxylase Gene (CYP27B1) Creates an Animal Model of Pseudovitamin D-Deficiency Rickets*

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Vitamin D

1979 • 3,814 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Manipulating the Mouse Embryo: A Laboratory Manual

2002 • 2,187 citations

The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed

1998 • 1,391 citations

Current Understanding of the Molecular Actions of Vitamin D

1998 • 1,259 citations

Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

1997 • 1,149 citations

Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia

1997 • 933 citations

25-Hydroxyvitamin D ₃ 1α-Hydroxylase and Vitamin D Synthesis

1997 • 528 citations

Methods of calcified tissue preparation

1985 • 494 citations

Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues

1984 • 486 citations

Osteopontin expression and function: Role in bone remodeling

1998 • 422 citations

Cloning of Human 25-Hydroxyvitamin D-1α-Hydroxylase and Mutations Causing Vitamin D-Dependent Rickets Type 1

1997 • 398 citations

Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones.

1986 • 398 citations

The Vitamin D Receptor and the Syndrome of Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets*

1999 • 363 citations

Inactivating Mutations in the 25-Hydroxyvitamin D₃1α-Hydroxylase Gene in Patients with Pseudovitamin D–Deficiency Rickets

1998 • 360 citations

Vitamin D. Basic Research and its Clinical Application

1979 • 318 citations

The 25-Hydroxyvitamin D 1-Alpha-Hydroxylase Gene Maps to the Pseudovitamin D-Deficiency Rickets (PDDR) Disease Locus

1997 • 318 citations

Serum 1,25-Dihydroxyvitamin D Levels in Normal Subjects and in Patients with Hereditary Rickets or Bone Disease

1978 • 239 citations

Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis

1989 • 238 citations

Cloning and expression of cDNA encoding 25‐hydroxyvitamin D₃ 24‐hydroxylase

1991 • 232 citations

Cloning and expression of rat 25-hydroxyvitamin D ₃ -1α-hydroxylase cDNA

1997 • 196 citations

Genetics of Vitamin D 1α-Hydroxylase Deficiency in 17 Families

1998 • 189 citations

Methods of calcified tissue preparation

1984 • 187 citations

Parathyroid hormone inhibits 25-hydroxyvitamin D3-24-hydroxylase mRNA expression stimulated by 1 alpha,25-dihydroxyvitamin D3 in rat kidney but not in intestine.

1992 • 186 citations

Linkage disequilibrium analysis in young populations: pseudo-vitamin D-deficiency rickets and the founder effect in French Canadians.

1996 • 138 citations

Osteocalcin gene promoter: Unlocking the secrets for regulation of osteoblast growth and differentiation

1998 • 134 citations

1,25(OH)2D2 production by T lymphocytes and alveolar macrophages recovered by lavage from normocalcemic patients with tuberculosis.

1990 • 134 citations

Vitamin D dependency: Replacement therapy with calcitriol

1981 • 120 citations

Complete Structure of the Human Gene for the Vitamin D 1α-Hydroxylase, P450c1α

1997 • 120 citations

In vitro synthesis of 1 alpha,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol by isolated calvarial cells.

1980 • 113 citations

Production of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 by growth zone and resting zone chondrocytes is dependent on cell maturation and is regulated by hormones and growth factors.

1992 • 105 citations

Mapping autosomal recessive vitamin D dependency type I to chromosome 12q14 by linkage analysis.

1990 • 93 citations

Novel Mutations in the 1α-Hydroxylase (P450c1) Gene in Three Families with Pseudovitamin D–Deficiency Rickets Resulting in Loss of Functional Enzyme Activity in Blood-Derived Macrophages

1999 • 92 citations

Two novel 1α-hydroxylase mutations in French-Canadians with vitamin D dependency rickets type I

1998 • 86 citations

Vitamin D 1α-Hydroxylase

2000 • 84 citations

Response to Crystalline 1α-Hydroxyvitamin D3 in Vitamin D Dependency

1975 • 76 citations

No Enzyme Activity of 25-Hydroxyvitamin D3 1α-Hydroxylase Gene Product in Pseudovitamin D Deficiency Rickets, Including That with Mild Clinical Manifestation

1999 • 75 citations

25-Hydroxyvitamin D 1α-Hydroxylase: Structure of the Mouse Gene, Chromosomal Assignment, and Developmental Expression

2001 • 57 citations

Vitamin D-Dependent Rickets: Actions of Parathyroid Hormone and 25-Hydroxycholecalciferol

1972 • 47 citations

Vitamin D: Role in the Calcium Economy

2005 • 37 citations

Vitamin D Pseudodeficiency

2005 • 28 citations

Evidence for 1,25-dihydroxyvitamin D3 production by cultured porcine alveolar macrophages

1991 • 24 citations

Normal 24-hydroxylation of vitamin D metabolites in patients with vitamin D-dependency rickets type I. Structural implications for the vitamin D hydroxylases

1992 • 19 citations

Synthesis of 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol by calvarial cells. Characterization of the enzyme systems

1987 • 16 citations