Insulin Signalling

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Protein Sorting by Transport Vesicles

1996 • 1,168 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

1980 • 1,066 citations

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

1980 • 1,042 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

1997 • 909 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin

1997 • 808 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.

1996 • 735 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Interaction of a Receptor Tyrosine Kinase, EGF-R, with Caveolins

1997 • 658 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

Caveolae and caveolins

1996 • 549 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

PROTEIN TYROSINE PHOSPHATASES

1993 • 532 citations

Cell-type and Tissue-specific Expression of Caveolin-2

1997 • 524 citations

Untitled

1998 • 523 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity.

1981 • 456 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.

1997 • 428 citations

Switching Signals On or Off by Receptor Dimerization

1998 • 428 citations

Cross-talk between the insulin and angiotensin signaling systems.

1996 • 410 citations

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

1997 • 381 citations

Structure, Function, and Regulation of the Mammalian Facilitative Glucose Transporter Gene Family

1996 • 369 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

Two EGF molecules contribute additively to stabilization of the EGFR dimer

1997 • 363 citations

Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 358 citations

The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family

1997 • 354 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

The Nature and Regulation of the Insulin Receptor: Structure and Function

1985 • 318 citations

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1997 • 316 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles

1997 • 301 citations

Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action.

1993 • 297 citations

Activation of Protein Kinase C (α, β, and ζ) by Insulin in 3T3/L1 Cells

1997 • 290 citations

Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes.

1997 • 282 citations

Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase

1993 • 277 citations

Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains

1995 • 276 citations

Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes.

1992 • 275 citations

Molecular Glue: Kinase Anchoring and Scaffold Proteins

1996 • 264 citations

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1995 • 263 citations

PDK1, one of the missing links in insulin signal transduction?¹

1997 • 246 citations

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

1994 • 240 citations

Syntaxin 4, VAMP2, and/or VAMP3/Cellubrevin Are Functional Target Membrane and Vesicle SNAP Receptors for Insulin-Stimulated GLUT4 Translocation in Adipocytes

1997 • 236 citations

The Structure and Function of P55^PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase

1995 • 235 citations

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

1994 • 234 citations

Osmotic Loading of Neutralizing Antibodies Demonstrates a Role for Protein-tyrosine Phosphatase 1B in Negative Regulation of the Insulin Action Pathway

1995 • 224 citations

Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae

1997 • 221 citations

PtdIns-3,4,5-P3

1998 • 220 citations

Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue

1997 • 217 citations

Characterization of Munc-18c and Syntaxin-4 in 3T3-L1 Adipocytes

1997 • 213 citations

Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.

1994 • 212 citations

Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells

1997 • 212 citations

The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells.

1996 • 211 citations

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

1994 • 200 citations

Insulin Receptor Substrate-2 Binds to the Insulin Receptor through Its Phosphotyrosine-binding Domain and through a Newly Identified Domain Comprising Amino Acids 591–786

1996 • 194 citations

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1996 • 193 citations

Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency

1996 • 187 citations

Protein tyrosine phosphatases as adhesion receptors

1995 • 182 citations

Differential Effects of Constitutively Active Phosphatidylinositol 3-Kinase on Glucose Transport, Glycogen Synthase Activity, and DNA Synthesis in 3T3-L1 Adipocytes

1997 • 179 citations

Signaling via the insulin-like growth factor-I receptor: Does it differ from insulin receptor signaling?

1996 • 169 citations

Intracellular Localization of Phosphatidylinositide 3-kinase and Insulin Receptor Substrate-1 in Adipocytes: Potential Involvement of a Membrane Skeleton

1998 • 169 citations

Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.

1988 • 164 citations

p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin

1997 • 161 citations

Overexpression of a Constitutively Active Form of Phosphatidylinositol 3-Kinase Is Sufficient to Promote Glut 4 Translocation in Adipocytes

1996 • 158 citations

Differential activities of protein tyrosine phosphatases in intact cells.

1993 • 155 citations

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1997 • 155 citations

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.

1995 • 149 citations

Roles of 1-Phosphatidylinositol 3-Kinase and ras in Regulating Translocation of GLUT4 in Transfected Rat Adipose Cells

1995 • 149 citations

Selective Down-regulation of the Insulin Receptor Signal by Protein-tyrosine Phosphatases α and ∊

1995 • 147 citations

Insulin-stimulated GLUT4 Translocation Is Mediated by a Divergent Intracellular Signaling Pathway

1995 • 146 citations

Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription

1993 • 146 citations

Morphological Changes Of The 3T3-L1 Fibroblast Plasma Membrane Upon Differentiation To The Adipocyte Form

1983 • 146 citations

Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells.

1994 • 145 citations

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

1998 • 143 citations

Insulin-stimulated Tyrosine Phosphorylation of Caveolin Is Specific for the Differentiated Adipocyte Phenotype in 3T3-L1 Cells

1997 • 143 citations

Novel mechanisms of RTK signal generation

1997 • 137 citations

Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport.

1996 • 135 citations

Baculovirus-based Expression of Mammalian Caveolin in Sf21 Insect Cells

1996 • 134 citations

Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 133 citations

Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue

1997 • 130 citations

The IRS-2 Gene on Murine Chromosome 8 Encodes a Unique Signaling Adapter for Insulin and Cytokine Action

1997 • 130 citations

Insulin-mediated Targeting of Phosphatidylinositol 3-Kinase to GLUT4-containing Vesicles

1996 • 129 citations

Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 127 citations

Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.

1994 • 126 citations

Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects.

1995 • 122 citations

Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance.

1994 • 122 citations

Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion

1997 • 121 citations

The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.

1993 • 120 citations

Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene

1996 • 117 citations

Expression of a Dominant Interfering Dynamin Mutant in 3T3L1 Adipocytes Inhibits GLUT4 Endocytosis without Affecting Insulin Signaling

1998 • 115 citations

Relationship between alpha subunit ligand occupancy and beta subunit autophosphorylation in insulin/insulin-like growth factor-1 hybrid receptors.

1993 • 105 citations

The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras.

1990 • 104 citations

Functional Association between the Insulin Receptor and the Transmembrane Protein-tyrosine Phosphatase LAR in Intact Cells

1997 • 100 citations

Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene, and Chromosomal Localization

1993 • 100 citations

Role of Insulin Receptor Substrate-1 and pp60 in the Regulation of Insulin-induced Glucose Transport and GLUT4 Translocation in Primary Adipocytes

1997 • 100 citations

Effect of Microinjection of a Low-M_r Human Placenta Protein Tyrosine Phosphatase on Induction of Meiotic Cell Division in Xenopus Oocytes

1990 • 99 citations

Endocytosis of the Glucose Transporter GLUT4 Is Mediated by the GTPase Dynamin

1998 • 94 citations

Signal transduction by the PDGF receptors

1994 • 93 citations

Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.

1994 • 91 citations

A Membrane-Anchored Cytoplasmic Domain of the Human Insulin Receptor Mediates a Constitutively Elevated Insulin-Independent Uptake of 2-Deoxyglucose*

1987 • 90 citations

Cloning, Tissue Expression, and Chromosomal Localization of the Mouse IRS-3 Gene

1997 • 89 citations

Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.

1994 • 88 citations

Thiazolidine Derivatives Ameliorate High Glucose-induced Insulin Resistance via the Normalization of Protein-tyrosine Phosphatase Activities

1995 • 85 citations

The 60 kDa Insulin Receptor Substrate Functions Like an IRS Protein (pp60^IRS3) in Adipose Cells

1997 • 83 citations

Cross-talk between Insulin Receptor and Integrin α5β1 Signaling Pathways

1998 • 82 citations

Transfection of DNA into Isolated Rat Adipose Cells by Electroporation:

1993 • 76 citations

Tyr624 and Tyr628 in Insulin Receptor Substrate-2 Mediate Its Association with the Insulin Receptor

1997 • 75 citations

Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1994 • 73 citations

Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine phosphatases expressed in a recombinant bacterial system

1992 • 72 citations

Different Subcellular Distribution and Regulation of Expression of Insulin Receptor Substrate (IRS)-3 from Those of IRS-1 and IRS-2

1998 • 72 citations

Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells.

1994 • 69 citations

Identification and cDNA Cloning of a Novel Mammalian C2 Domain-Containing Phosphoinositide 3-Kinase, HsC2-PI3K

1997 • 66 citations

Action of Insulin Receptor Substrate-3 (IRS-3) and IRS-4 to Stimulate Translocation of GLUT4 in Rat Adipose Cells

1999 • 64 citations

Angiotensin II Stimulates Tyrosine Phosphorylation and Activation of Insulin Receptor Substrate 1 and Protein-tyrosine Phosphatase 1D in Vascular Smooth Muscle Cells

1997 • 60 citations

Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes.

1990 • 60 citations

Conformational Changes of the Insulin Receptor upon Insulin Binding and Activation As Monitored by Fluorescence Spectroscopy

1997 • 57 citations

Insulin Receptor Substrate-2 (IRS-2) Can Mediate the Action of Insulin to Stimulate Translocation of GLUT4 to the Cell Surface in Rat Adipose Cells

1997 • 52 citations

High Glucose Condition Activates Protein Tyrosine Phosphatases and Deactivates Insulin Receptor Function in Insulin-Sensitive Rat 1 Fibroblasts

1994 • 51 citations

Cross-talk between the Platelet-derived Growth Factor and the Insulin Signaling Pathways in 3T3-L1 Adipocytes

1997 • 51 citations

A role for Raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport

1994 • 48 citations

Functional Roles of the Shc Phosphotyrosine Binding and Src Homology 2 Domains in Insulin and Epidermal Growth Factor Signaling

1996 • 46 citations

A Phosphotyrosyl Mimetic Peptide Reverses Impairment of Insulin-Stimulated Translocation of GLUT4 Caused by Overexpression of PTP1B in Rat Adipose Cells

1998 • 44 citations

Insulin signal transduction pathways

1994 • 44 citations

Identification of Four Novel Human Phosphoinositide 3-Kinases Defines a Multi-isoform Subfamily

1997 • 40 citations

Targeting of Constitutively Active Phosphoinositide 3-Kinase to GLUT4-containing Vesicles in 3T3-L1 Adipocytes

1998 • 39 citations

Src homology 2 domains of protein tyrosine phosphatase are associated in vitro with both the insulin receptor and insulin receptor substrate‐1 via different phosphotyrosine motifs

1994 • 36 citations

Overexpression of Ha-ras Selectively in Adipose Tissue of Transgenic Mice

1996 • 35 citations

Cellular signaling by receptor tyrosine kinases.

1993 • 35 citations

Effects of Overexpressing Wild-Type and Mutant PDGF Receptors on Translocation of GLUT4 in Transfected Rat Adipose Cells

1996 • 33 citations

Overexpression of Protein Tyrosine Phosphatase-α (PTP-α) but not PTP-κ Inhibits Translocation of GLUT4 in Rat Adipose Cells

1999 • 32 citations

Molecular determinants of insulin action

1993 • 32 citations

G-Protein-Linked Receptors as Tyrosine Kinase Substrates

1998 • 30 citations

α2-Heremans Schmid Glycoprotein Inhibits Insulin-Stimulated Elk-1 Phosphorylation, But Not Glucose Transport, in Rat Adipose Cells**This work was supported in part by a Research Award grant from the American Diabetes Association (to M.J.Q.).

1998 • 25 citations

Glut4 Is Targeted to Specific Vesicles in Adipocytes of Transgenic Mice Overexpressing Glut4 Selectively in Adipose Tissue

1996 • 21 citations

A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation

1991 • 18 citations

Dephosphorylation of autophosphorylated insulin and epidermal-growth-factor receptors by two major subtypes of protein-tyrosine-phosphatase from human placenta

1991 • 17 citations

The carboxyl‐terminal domain of insulin‐like growth factor‐I receptor interacts with the insulin receptor and activates its protein tyrosine kinase

1998 • 6 citations