Conformational Changes of the Insulin Receptor upon Insulin Binding and Activation As Monitored by Fluorescence Spectroscopy

Mutations in the Insulin Receptor Gene

1992 • 294 citations

Enzyme Dynamics: The Statistical Physics Approach

1979 • 220 citations

The insulin receptor. Structural basis for high affinity ligand binding.

1987 • 117 citations

Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping

1988 • 104 citations

Transmembrane signaling by the human insulin receptor kinase. Relationship between intramolecular beta subunit trans- and cis-autophosphorylation and substrate kinase activation.

1992 • 98 citations

Structural requirements for the transmembrane activation of the insulin receptor kinase.

1986 • 93 citations

Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor.

1984 • 85 citations

Mutational analysis of insulin receptor function

1993 • 79 citations

Conformational Changes in the α- and β-Subunits of the Insulin Receptor Identified by Anti-peptide Antibodies

1989 • 74 citations

Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor.

1984 • 67 citations

Immobilized insulin for high capacity affinity chromatography of insulin receptors.

1991 • 63 citations

Structural organization of the human insulin receptor ectodomain

1992 • 62 citations

BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor.

1993 • 62 citations

Deletion analysis of the human insulin receptor ectodomain reveals independently folded soluble subdomains and insulin binding by a monomeric alpha-subunit.

1990 • 56 citations

The insulin receptor activation process involves localized conformational changes

1992 • 55 citations

Sulphydryl agents modulate insulin- and epidermal growth factor (EGF)-receptor kinase via reaction with intracellular receptor domains: differential effects on basal versus activated receptors

1993 • 54 citations

Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation.

1991 • 48 citations

Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro.

1992 • 47 citations

Insulin-dependent covalent reassociation of isolated alpha beta heterodimeric insulin receptors into an alpha 2 beta 2 heterotetrameric disulfide-linked complex.

1988 • 44 citations