Identification of Four Novel Human Phosphoinositide 3-Kinases Defines a Multi-isoform Subfamily

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints

1995 • 509 citations

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1996 • 492 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

1993 • 449 citations

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

1991 • 427 citations

Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.

1989 • 413 citations

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

1995 • 349 citations

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.

1994 • 270 citations

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

1993 • 259 citations

Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase

1992 • 240 citations

The Structure and Function of P55^PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase

1995 • 235 citations

AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain.

1994 • 175 citations

Cloning and Characterization of a Wortmannin-sensitive Human Phosphatidylinositol 4-Kinase

1997 • 171 citations

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours.

1994 • 162 citations

Mouse p170 Is a Novel Phosphatidylinositol 3-Kinase Containing a C2 Domain

1996 • 154 citations

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

1995 • 137 citations

Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells

1994 • 131 citations

A Phosphatidylinositol (PI) Kinase Gene Family in Dictyostelium discoideum: Biological Roles of Putative Mammalian p110 and Yeast Vps34p PI 3-Kinase Homologs during Growth and Development

1995 • 126 citations

Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene

1996 • 117 citations

Structural and functional diversity of phosphoinositide 3-kinases

1996 • 100 citations

Cloning and characterization of a human phosphatidylinositol 4-kinase.

1994 • 95 citations

A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation.

1994 • 91 citations

Molecular Cloning, cDNA Sequence, and Chromosomal Localization of the Human Phosphatidylinositol 3-Kinase p110α (PIK3CA) Gene

1994 • 91 citations

Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology

1995 • 91 citations

Novel protein kinases expressed in human breast cancer

1993 • 74 citations

Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns

1992 • 73 citations

Cpk Is a Novel Class of Drosophila PtdIns 3-Kinase Containing a C2 Domain

1996 • 65 citations

The study of phosphoinositide 3-kinase function.

1996 • 57 citations

Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase

1997 • 39 citations

Rapid Characterisation of differentially expressed members of multigene families

1992 • 3 citations