Insulin-mediated Targeting of Phosphatidylinositol 3-Kinase to GLUT4-containing Vesicles

The insulin signaling system.

1994 • 1,733 citations

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

1980 • 1,066 citations

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

1980 • 1,042 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Molecular cloning and characterization of an insulin-regulatable glucose transporter

1989 • 919 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.

1991 • 874 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.

1990 • 325 citations

The IRS-1 signaling system

1994 • 310 citations

Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites

1994 • 297 citations

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

1994 • 277 citations

Signal transduction and membrane traffic: The PITP/phosphoinositide connection

1995 • 261 citations

Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling.

1992 • 225 citations

Regulation of Phosphatidylinositol 3′-Kinase by Tyrosyl Phosphoproteins

1995 • 222 citations

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle.

1993 • 220 citations

Immunoelectron microscopic demonstration of insulin-stimulated translocation of glucose transporters to the plasma membrane of isolated rat adipocytes and masking of the carboxyl-terminal epitope of intracellular GLUT4.

1991 • 162 citations

Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain

1993 • 156 citations

Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation

1991 • 149 citations

Insulin action on the internalization of the GLUT4 glucose transporter in isolated rat adipocytes

1993 • 149 citations

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.

1995 • 149 citations

Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells.

1994 • 145 citations

Dynamics of Signaling during Insulin-stimulated Endocytosis of Its Receptor in Adipocytes

1995 • 124 citations

Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate.

1991 • 123 citations

Photoaffinity labeling of insulin-sensitive hexose transporters in intact rat adipocytes. Direct evidence that latent transporters become exposed to the extracellular space in response to insulin.

1984 • 120 citations

Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1.

1992 • 119 citations

Comparison of glucose-transporter-containing vesicles from rat fat and muscle tissues: evidence for a unique endosomal compartment

1995 • 103 citations

Molecular Actions of Insulin on Glucose Transport

1995 • 98 citations

Insulin Regulation of Membrane-associated Insulin Receptor Substrate 1

1995 • 97 citations

Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.

1994 • 91 citations

Complex regulation of simple sugar transport in insulin-responsive cells

1992 • 89 citations

A distinct class of intracellular storage vesicles, identified by expression of the glucose transporter GLUT4.

1994 • 85 citations

Protein synthesis inhibitors activate glucose transport without increasing plasma membrane glucose transporters in 3T3-L1 adipocytes

1991 • 84 citations

Phosphatidylinositol 4-kinase is a component of glucose transporter (GLUT 4)-containing vesicles

1991 • 83 citations

Insulin signalling: the role of insulin receptor substrate 1

1994 • 76 citations

The role of kinase activity and the kinase insert region in ligand-induced internalization and degradation of the c-fms protein.

1991 • 75 citations

Insulin signal transduction pathways

1994 • 44 citations