A role for Raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Molecular cloning and characterization of an insulin-regulatable glucose transporter

1989 • 919 citations

Sublines of mouse 3T3 cells that accumulate lipid

1974 • 918 citations

Molecular Biology of Mammalian Glucose Transporters

1990 • 852 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Identification of a novel gene encoding an insulin-responsive glucose transporter protein

1989 • 601 citations

Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein.

1986 • 550 citations

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1990 • 529 citations

The insulin receptor and the molecular mechanism of insulin action.

1988 • 426 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.

1990 • 325 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

Growth factors rapidly induce expression of the glucose transporter gene.

1988 • 263 citations

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

1989 • 240 citations

Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes.

1990 • 236 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

The New Elements of Insulin Signaling: Insulin Receptor Substrate-1 and Proteins With SH2 Domains

1993 • 221 citations

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1991 • 208 citations

Identification of c-fos sequences involved in induction by insulin and phorbol esters.

1988 • 184 citations

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.

1993 • 177 citations

Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester.

1985 • 155 citations

Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation.

1990 • 148 citations

Identification of insulin‐stimulated protein kinase‐1 as the rabbit equivalent of rsk^mo‐2

1993 • 141 citations

Differential regulation of two distinct glucose transporter species expressed in 3T3-L1 adipocytes: effect of chronic insulin and tolbutamide treatment.

1989 • 139 citations

Transactivation of c-fos and β-actin genes by raf as a step in early response to transmembrane signals

1990 • 138 citations

The Acquisition of Increased Insulin-responsive Hexose Transport in 3T3-L1 Adipocytes Correlates with Expression of a Novel Transporter Gene

1989 • 137 citations

Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes.

1986 • 137 citations

The Insulin-Sensitive Glucose Transporter

1992 • 135 citations

Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes.

1993 • 132 citations

Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.

1993 • 130 citations

Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cells.

1992 • 119 citations

Purification and characterisation of the insulin‐stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II

1991 • 117 citations

Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase

1993 • 116 citations

Chronic treatment with insulin selectively down-regulates cell-surface GLUT4 glucose transporters in 3T3-L1 adipocytes

1991 • 99 citations

Insulin activates the Raf-1 protein kinase.

1990 • 99 citations

Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1993 • 98 citations

The ras signaling pathway mimics insulin action on glucose transporter translocation.

1993 • 96 citations

Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts.

1992 • 95 citations

Biosynthetic precursors and in vitro translation products of the glucose transporter of human hepatocarcinoma cells, human fibroblasts, and murine preadipocytes.

1985 • 90 citations

Complex regulation of simple sugar transport in insulin-responsive cells

1992 • 89 citations

The regulation by insulin of glucose transporter gene expression in 3T3 adipocytes

1989 • 74 citations

Differential regulation of the HepG2 and adipocyte/muscle glucose transporters in 3T3L1 adipocytes. Effect of chronic glucose deprivation

1990 • 73 citations

Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection.

1992 • 63 citations

Relation between the insulin receptor number in cells, autophosphorylation and insulin-stimulated Ras.GTP formation.

1992 • 60 citations

Characterization of insulin-stimulated protein serine/threonine kinases in CHO cells expressing human insulin receptors with point and deletion mutations

1992 • 49 citations

Long term regulation of glucose transporters by insulin in mature 3T3-F442A adipose cells. Differential effects on two glucose transporter subtypes.

1990 • 20 citations