Two EGF molecules contribute additively to stabilization of the EGFR dimer

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

1989 • 2,603 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Cytokine signal transduction

1994 • 1,358 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1994 • 665 citations

Rational Design of Potent Antagonists to the Human Growth Hormone Receptor

1992 • 633 citations

GNOM – a program package for small-angle scattering data processing

1991 • 625 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

1994 • 520 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

1995 • 478 citations

Binding in the growth hormone receptor complex.

1996 • 434 citations

Betacellulin: a mitogen from pancreatic beta cell tumors

1993 • 392 citations

Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

1996 • 376 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

The Cellular Response to Neuregulins Is Governed by Complex Interactions of the erbB Receptor Family

1995 • 364 citations

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1990 • 359 citations

Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

1995 • 350 citations

Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities

1996 • 311 citations

The epidermal growth factor receptor as a multifunctional allosteric protein

1988 • 286 citations

Epiregulin

1995 • 265 citations

Cytokine structural taxonomy and mechanisms of receptor engagement

1993 • 252 citations

Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.

1996 • 229 citations

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

1988 • 226 citations

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.

1988 • 226 citations

Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.

1989 • 197 citations

Dimerization of the Extracellular Domain of the Erythropoietin (EPO) Receptor by EPO: One High-Affinity and One Low-Affinity Interaction

1996 • 196 citations

Immunoaffinity purification of the epidermal growth factor receptor. Stoichiometry of binding and kinetics of self-phosphorylation.

1984 • 186 citations

Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.

1988 • 178 citations

Epidermal growth factor binding induces a conformational change in the external domain of its receptor.

1989 • 175 citations

Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.

1990 • 132 citations

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation

1993 • 129 citations

Kit Receptor Dimerization Is Driven by Bivalent Binding of Stem Cell Factor

1997 • 120 citations

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.

1988 • 119 citations

Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain

1991 • 105 citations

Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.

1992 • 104 citations

Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor

1995 • 102 citations

Three classes of epidermal growth factor receptors on HeLa cells.

1991 • 101 citations

EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain.

1991 • 100 citations

Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies.

1985 • 98 citations

Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors

1994 • 94 citations

The Structural Basis for the Specificity of Epidermal Growth Factor and Heregulin Binding

1995 • 91 citations

Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.

1993 • 83 citations

HER4-mediated Biological and Biochemical Properties in NIH 3T3 Cells

1996 • 80 citations

p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases.

1992 • 78 citations

Binding of Neu Differentiation Factor with the Extracellular Domain of Her2 and Her3

1995 • 76 citations

Implications of epidermal growth factor (EGF) induced egf receptor aggregation

1992 • 74 citations

Human Stem Cell Factor Dimer Forms a Complex with Two Molecules of the Extracellular Domain of Its Receptor, Kit

1996 • 71 citations

Signal transmission by epidermal growth factor receptor: coincidence of activation and dimerization

1992 • 71 citations

Dimerization of the Extracellular Domain of Granulocyte-Colony Stimulating Factor Receptor by Ligand Binding: A Monovalent Ligand Induces 2:2 Complexes

1996 • 61 citations

Neu Differentiation Factor Inhibits EGF Binding

1995 • 61 citations

Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors.

1994 • 61 citations

The secreted form of the epidermal growth factor receptor. Characterization and crystallization of the receptor-ligand complex.

1990 • 59 citations

A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses.

1992 • 57 citations

The Extracellular Domain of the Epidermal Growth Factor Receptor

1994 • 56 citations

Noncontiguous regions in the extracellular domain of EGF receptor define ligand-binding specificity.

1991 • 53 citations

A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor.

1993 • 50 citations

Activation of Epidermal Growth Factor Receptor by Epidermal Growth Factor

1996 • 44 citations

Human epidermal growth factor receptor residue covalently cross-linked to epidermal growth factor.

1990 • 43 citations

Regulation of Growth

1965 • 40 citations

Direct identification of residues of the epidermal growth factor receptor in close proximity to the amino terminus of bound epidermal growth factor.

1992 • 39 citations

Cooperativity in associating proteins. Monomer-dimer equilibrium coupled to ligand binding

1974 • 38 citations

Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.

1990 • 27 citations

Localization of a Major Receptor-Binding Domain for Epidermal Growth Factor by Affinity Labeling

1988 • 15 citations

Biological Activities

2024 • 5 citations