Regulation of Lysosomal Endopeptidases in Malignant Neoplasia

ras GENES

1987 • 3,818 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1

1988 • 887 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

The cystatins: Protein inhibitors of cysteine proteinases

1991 • 813 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Lysosomes and storage diseases

1973 • 745 citations

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

1991 • 595 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases.

1988 • 584 citations

Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling

1980 • 574 citations

Lysosomes in biology and pathology

1975 • 511 citations

Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids.

1986 • 499 citations

Trafficking of lysosomal enzymes ¹

1987 • 497 citations

The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.

1990 • 492 citations

Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues

1992 • 417 citations

Metalloproteinases and cancer invasion.

1990 • 399 citations

Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts.

1990 • 390 citations

Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH.

1989 • 387 citations

Small GTP-binding proteins in vesicular transport

1990 • 381 citations

The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor.

1989 • 372 citations

Lysosomal Cathepsin B: Correlation with Metastatic Potential

1981 • 370 citations

A Single Receptor Binds Both Insulin-Like Growth Factor II and Mannose-6-Phosphate

1988 • 363 citations

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

1991 • 347 citations

Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C).

1986 • 332 citations

Cloning and sequence analysis of cDNA for human cathepsin D.

1985 • 318 citations

Rapid Cytoplasmic Turnover of c-myc mRNA: Requirement of the 3′ Untranslated Sequences

1987 • 302 citations

Mammalian Proteases : A Glossary and Bibliography

1986 • 299 citations

Evolution of proteins of the cystatin superfamily

1990 • 297 citations

The place of human γ-trace (cystatin C) amongst the cysteine proteinase inhibitors

1984 • 294 citations

The cystatins: a new class of peptidase inhibitors

1987 • 293 citations

Proteinase inhibitors

1996 • 275 citations

Molecular mechanisms of bone resorption by the osteoclast

1989 • 262 citations

Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas

1978 • 260 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family.

1991 • 259 citations

Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

1986 • 245 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

Regulation of endocytic pH by the Na+,K+-ATPase in living cells.

1989 • 228 citations

Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.

1989 • 228 citations

Cathepsin B: association with plasma membrane in metastatic tumors.

1986 • 222 citations

Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.

1986 • 214 citations

Biosynthesis, glycosylation, movement through the Golgi system, and transport to lysosomes by an N-linked carbohydrate-independent mechanism of three lysosomal integral membrane proteins.

1986 • 212 citations

Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases

1986 • 209 citations

Expression of cathepsin L in human tumors.

1991 • 208 citations

MUTATION IN CYSTATIN C GENE CAUSES HEREDITARY BRAIN HAEMORRHAGE

1988 • 206 citations

Cathepsin B and cystatins: evidence for a role in cancer progression.

1990 • 206 citations

Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.

1982 • 200 citations

Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D.

1981 • 188 citations

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

1990 • 187 citations

The expression of high molecular weight kininogen on human umbilical vein endothelial cells.

1988 • 186 citations

Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene

1994 • 184 citations

Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C

1987 • 183 citations

Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences.

1987 • 182 citations

Rat procathepsin B. Proteolytic processing to the mature form in vitro.

1992 • 181 citations

Regulation of Cathepsin-D and pS2 Gene Expression by Growth Factors in MCF7 Human Breast Cancer Cells

1989 • 180 citations

A vacuolar type H(+)-ATPase regulates cytoplasmic pH in murine macrophages.

1990 • 178 citations

Mechanism of inhibition of papain by chicken egg white cystatin

1989 • 173 citations

Basement membrane type IV collagen degradation: evidence for the involvement of a proteolytic cascade independent of metalloproteinases.

1990 • 173 citations

The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L

1987 • 172 citations

Human cystatin C. role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase

1991 • 167 citations

Identification of latent procathepsins B and L in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro

1988 • 161 citations

Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells.

1991 • 156 citations

Secretion of proteinases from malignant and nonmalignant human breast tissue.

1980 • 156 citations

Cystatin-like cysteine proteinase inhibitors from human liver

1984 • 152 citations

The role of cathepsin L in malignant transformation.

1990 • 150 citations

Cystatins — Inhibitors of Cysteine Proteinases

1992 • 150 citations

Activity and Deletion Analysis of Recombinant Human Cathepsin L Expressed in Escherichia coli

1989 • 147 citations

Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells.

1987 • 147 citations

The major excreted protein of transformed fibroblasts is an activable acid-protease.

1986 • 147 citations

CG dinucleotide clusters in MHC genes and in 5′ demethylated genes

1984 • 146 citations

Tumor cell surface carbohydrate and the metastatic phenotype

1987 • 144 citations

Cysteine Proteinases and their Inhibitors

1986 • 142 citations

Kinetics of the pH-induced inactivation of human cathepsin L

1993 • 140 citations

Cathepsin D: A protease involved in breast cancer metastasis

1990 • 140 citations

Stefins and lysosomal cathepsins B, L and D in human breast carcinoma

1992 • 138 citations

Cloning and characterization of a mouse cysteine proteinase.

1986 • 137 citations

Kininogens revisited

1986 • 134 citations

Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.

1988 • 133 citations

Tumor promoters and kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA

1980 • 130 citations

Degradation of laminin by human tumor cathepsin B

1989 • 130 citations

Biosynthesis of lysosomal endopeptidases

1989 • 128 citations

Cathepsin D isozymes from porcine spleens. Large scale purification and polypeptide chain arrangements.

1979 • 127 citations

Estrogens and growth factors induce the mRNA of the 52K-pro-cathepsin-D secreted by breast cancer cells

1988 • 123 citations

Cysteine protease activities and tumor development in human colorectal carcinoma.

1989 • 123 citations

Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues.

1989 • 119 citations

Human tumour cathepsin B. Comparison with normal liver cathepsin B

1992 • 116 citations

Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles.

1990 • 116 citations

Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes.

1990 • 114 citations

Purification and Some Characteristics of the Human Epidermal SH-Protease Inhibitor

1978 • 113 citations

Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinoma.

1991 • 109 citations

Temperature effect on endocytosis and exocytosis by rabbit alveolar macrophages

1989 • 107 citations

Stromelysin/transin and tumor progression.

1990 • 104 citations

Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver

1985 • 104 citations

Biosynthesis of cathepsin B in cultured normal and I-cell fibroblasts.

1987 • 104 citations

Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells.

1989 • 103 citations

Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane

1988 • 102 citations

Effects of UV, 4NQO and TPA on gene expression in cultured human epidermal keratinocytes

1987 • 100 citations

Isolation and sequence of a cDNA for human pro-(cathepsin L)

1988 • 98 citations

Role of tumor cell glycoproteins immunologically related to glycoproteins Ib and IIb/IIIa in tumor cell‐platelet and tumor cell‐matrix interactions

1988 • 98 citations

Immunodetection of cathepsins b and l present in and secreted from human pre‐malignant and malignant colorectal tumour cell lines

1989 • 97 citations

Carboxyl-terminal proteolytic processing during biosynthesis of the lysosomal enzymes .beta.-glucuronidase and cathepsin D

1983 • 95 citations

Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages

1988 • 94 citations

Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme

1992 • 94 citations

Cloning, genomic organization, and chromosomal localization of human cathepsin L.

1993 • 94 citations

Kininogen substrates for trypsin and cathepsin D in human, rabbit and rat plasmas

1983 • 93 citations

Cloning and Sequencing of the 52K Cathepsin D Complementary Deoxyribonucleic Acid of MCF7 Breast Cancer Cells and Mapping on Chromosome 11

1988 • 91 citations

Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras‐transformed NIH 3T3 cells

1992 • 91 citations

Characterization of recombinant rat cathepsin B and nonglycosylated mutants expressed in yeast. New insights into the pH dependence of cathepsin B-catalyzed hydrolyses.

1992 • 89 citations

Modulation of phagocytosis-associated respiratory burst by human cystatin C: Role of the N-terminal tetrapeptide LysProProArg

1990 • 87 citations

Procathepsins L and D are membrane-bound in acidic microsomal vesicles

1991 • 87 citations

The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor

1989 • 86 citations

Membrane-associated cathepsin L: A role in metastasis of melanomas

1989 • 84 citations

Interrelationship of active and latent secreted human cathepsin B precursors

1986 • 82 citations

Bovine stefin C, a new member of the stefin family.

1993 • 82 citations

Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer

1989 • 79 citations

Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages

1989 • 79 citations

Cystatin C and cathepsin B in human colon carcinoma: Expression by cell lines and matrix degradation

1992 • 78 citations

Molecular Organization of the Human Cathepsin D Gene

1991 • 75 citations

The NH2-terminal 21 amino acid residues are not essential for the papain-inhibitory activity of oryzacystatin, a member of the cystatin superfamily. Expression of oryzacystatin cDNA and its truncated fragments in Escherichia coli.

1988 • 75 citations

Different Tissue Distributions of Two Types of Thiol Proteinase Inhibitors from Rat Liver and Epidermis1

1984 • 75 citations

Properties of a plasma membrane-associated cathepsin B-like cysteine proteinase in metastatic B16 melanoma variants.

1987 • 73 citations

Phosphorylated cystatin α is a natural substrate of epidermal transglutaminase for formation of skin cornified envelope

1992 • 73 citations

Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin

1987 • 73 citations

Oligosaccharide units of lysosomal cathepsin D from porcine spleen. Amino acid sequence and carbohydrate structure of the glycopeptides.

1983 • 68 citations

Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts.

1990 • 67 citations

Plasma Membrane-Associated Cysteine Proteinases in Human and Animal Tumors

1987 • 65 citations

Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.

1988 • 64 citations

The subcellular localization of soluble and membrane-bound lysosomal enzymes in I-cell fibroblasts: a comparative immunocytochemical study.

1985 • 63 citations

A latent thiol proteinase from ascitic fluid of patients with neoplasia

1981 • 63 citations

Modulation of the transport of a lysosomal enzyme by PDGF.

1990 • 59 citations

Cysteine proteinases and inhibitors in inflammation: their role in periodontal disease.

1993 • 59 citations

Ras (proto)oncogene induces N-linked carbohydrate modification: temporal relationship with induction of invasive potential.

1988 • 59 citations

Novel carbohydrate structures of cathepsin B from porcine spleen.

1984 • 58 citations

Cysteine proteinase inhibitors and rasgene products share the same biological activities including tranforming activity toward NIH3T3 mouse fibroblasts and the differentiation-inclucing activity toward PC12 rat pheochromocytoma cells

1990 • 58 citations

Cell kinetic analysis of human brain tumors by in situ double labelling with bromodeoxyuridine and iododeoxyuridine

1992 • 58 citations

A cysteine proteinase secreted from human breast tumours is immunologically related to cathepsin B

1982 • 58 citations

Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis

1988 • 57 citations

Human cystatins in normal and diseased tissues — a review

1987 • 57 citations

Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts.

1990 • 56 citations

Isolation and preliminary characterization of the major membrane boundaries of the endocytic pathway in lymphocytes.

1990 • 56 citations

Biological and clinical significance of cathepsin D in breast cancer.

1990 • 56 citations

Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene

1994 • 55 citations

Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma

1989 • 55 citations

Biosynthesis and processing of lysosomal cathepsin L in primary cultures of rat hepatocytes

1988 • 55 citations

The Structure of the Mouse Cathepsin B Gene and Its Putative Promoter

1991 • 55 citations

Porcine spleen cathepsin B is an exopeptidase.

1986 • 52 citations

Identification of a BALB/c-3T3 cell protein modulated by platelet-derived growth factor.

1983 • 51 citations

Kininogens, Kinins and Kinships

1989 • 49 citations

Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B.

1986 • 48 citations

Localization of cathepsin B in two human lung cancer cell lines.

1990 • 48 citations

Cathepsin B to cysteine proteinase inhibitor balance in metastatic cell subpopulations isolated from murine tumors.

1990 • 47 citations

Biosynthesis of lysosomal cathepsins B and H in cultured rat hepatocytes

1988 • 45 citations

Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor.

1990 • 45 citations

Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

1991 • 45 citations

Enhanced levels of cathepsin B mRNA in murine tumors

1989 • 45 citations

c‐Ha‐ras gene products are potent inhibitors of cathepsins B and L

1987 • 44 citations

Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.

1988 • 44 citations

Intermediates in denaturation of a small globular protein, recombinant human stefin B.

1992 • 43 citations

The potential role of human kidney cortex cysteine proteinases in glomerular basement membrane degradation

1989 • 42 citations

Determination of Cathepsins B and H in Sera and Synovial Fluids of Patients with Different Joint Diseases

1990 • 42 citations

Studies of the biosynthesis of the mannose 6-phosphate receptor in receptor-positive and -deficient cell lines.

1983 • 42 citations

The N-terminal amino acid sequences of the heavy and light chains of human cathepsin L Relationship to a cDNA clone for a major cysteine proteinase from a mouse macrophage cell line

1986 • 42 citations

Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels

1990 • 41 citations

Structural Studies on the Carbohydrate Moieties of Rat Liver Cathepsins B and H1

1985 • 41 citations

Protein determinants impair recognition of procathepsin L phosphorylated oligosaccharides by the cation-independent mannose 6-phosphate receptor.

1990 • 40 citations

Cathepsin D gene of human MCF7 cells contains estrogen-responsive sequences in its 5′ proximal flanking region

1991 • 40 citations

Cytochemical and biochemical evidence of cathepsin B in malignant, transformed and normal breast epithelial cells

1987 • 38 citations

Gene structure and 5'‐upstream sequence of rat cathepsin L

1989 • 37 citations

Immunocytochemical localization of cathepsins B, H, and their endogenous inhibitor, cystatin beta, in islet endocrine cells of rat pancreas.

1988 • 37 citations

Different Forms of Human Cystatin C

1990 • 37 citations

Studies on the reactive site of the cystatin superfamily using recombinant cystatin A mutants

1989 • 35 citations

ras proteins: biological effects and biochemical targets (review).

1989 • 34 citations

In vitro translation and processing of cathepsin B of Schistosoma mansoni.

1990 • 33 citations

Molecular Characterization and Mapping of Murine Genes Encoding Three Members of the Stefin Family of Cysteine Proteinase Inhibitors

1993 • 32 citations

Gene structure of rat cathepsin H

1989 • 30 citations

Cystatins and stefins in ascites fluid from ovarian carcinoma

1992 • 30 citations

Enzymatically active cathepsin B dissociating from its inhibitor complexes is elevated in blood plasma of patients with septic shock and some malignant tumors.

1988 • 30 citations

The glycosylation state of the precursors of the cathepsin B-like proteinase from human malignant ascitic fluid: Possible implication in the secretory pathway of these proenzymes

1989 • 30 citations

Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes

1985 • 30 citations

Endosomes can undergo an ATP-dependent density increase in the absence of dense lysosomes.

1990 • 29 citations

Mouse procathepsin L lacking a functional glycosylation site is properly folded, stable, and secreted by NIH 3T3 cells

1993 • 29 citations

Gene structure of mouse cathepsin B

1990 • 29 citations

Glycosylation of procathepsin L does not account for species molecular-mass differences and is not required for proteolytic activity

1989 • 29 citations

Role for cathepsin B and cystatins in tumor growth and progression.

1990 • 29 citations

Downstream sequences mediate induction of the mouse cathepsin L promoter by phorbol esters.

1991 • 28 citations

Behaviour of dendritic reticulum cells possessing immunoreactive acid cysteine‐proteinase inhibitor in human lymphoid secondary follicles and in follicular‐centre cell lymphomas

1985 • 26 citations

Cathepsin B-like activity in viable tumor cells isolated from rodent tumors.

1985 • 26 citations

Human cathepsin B-encoding cDNAs: Sequence variations in the 3′-untranslated region

1994 • 24 citations

A FINE-STRUCTURE LINKAGE MAP FOR CHROMOSOME-13

1989 • 23 citations

Inhibition of cathepsin L-induced degradation of epidermal growth factor receptors by c-Ha-ras gene products

1988 • 23 citations

Endogenous inhibitors of lysosomal proteinases.

1983 • 22 citations

The malignant phenotype and cysteine proteinases.

1991 • 22 citations

N-terminal variants of recombinant stefin B: effect on affinity for papain and cathepsin B.

1990 • 21 citations

Demonstration of proteinase inhibitors cystatin A, B and C in breast cancer and in cell lines MCF-7 and ZR-75-1.

1989 • 21 citations

Cysteine Endopeptidases and Their Inhibitors in Malignant Progression of Rat Embryo Fibroblasts

1992 • 20 citations

Cysteine proteinase inhibitors produced by mononuclear phagocytes

1984 • 19 citations

Transient alterations in the expression of protease and extracellular matrix genes during metastatic lung colonization by H-ras-transformed 10T1/2 fibroblasts.

1990 • 18 citations

A thiol protease inhibitor released from cultured human malignant melanoma cells.

1984 • 18 citations

c-Ha-Ras mutants with point mutations in Gln-Val-Val region have reduced inhibitory activity toward cathepsin B

1993 • 17 citations

Occurrence of acid and neutral cysteine proteinase inhibitors in epidermal malignancies: Immunohistochemical study

1984 • 17 citations

Mutations in the QVVAG region of the cysteine proteinase inhibitor stefin B.

1990 • 16 citations

Inhibition of the cathepsin B like proteinase by a low molecular weight cysteine-proteinase inhibitor from ascitic fluid and plasma α₂ macroglobulin

1986 • 15 citations

Cysteine proteinase inhibitors in human cancerous tissues and fluids.

1990 • 15 citations

Structural organization of the gene encoding rat cystatin β

1992 • 14 citations

Acid and neutral cysteine proteinase inhibitor in normal uterine portio and in squamo-epithelial metaplasia, dysplasias and infiltrative carcinoma of the uterine portio

1984 • 14 citations

Incorporation and degradation by kidney lysosomes of cystatin α injected intravenously

1992 • 12 citations

A membrane‐associated cysteine protease inhibitor from murine hepatoma

1992 • 12 citations

A Taql DNA polymorphism in the human cathepsin B gene (CTSB)

1990 • 10 citations

Gene mapping of human cathepsins and cystatins.

1991 • 10 citations

Decreased vacuolar acidification capacity in drug-resistant rat liver preneoplastic nodules.

1989 • 9 citations

Anticarcinogenic Activities of Naturally Occurring Cysteine Proteinase Inhibitors

1993 • 8 citations

Cysteine proteinase inhibitors in human squamous cell carcinoma

1989 • 8 citations

Cysteine proteinase inhibitors in human melanoma transplanted into nude mice.

1988 • 8 citations

v‐Ha‐Ras insertion/deletion mutants with reduced protease‐inhibitory activity have no transforming activity

1993 • 6 citations

Cysteine protease inhibitors isolated from human malignant melanoma tissue.

1985 • 6 citations

A 43-kDa papain inhibitor produced by a cultured human epidermal cell line

1986 • 6 citations

Cysteine Proteinase-Inhibitory Activity ofrasGene Product is not Affected by Mutations at GTPase-Activating Protein-Binding Sites

1989 • 5 citations

High affinity binding of rat brain cathepsin B to purified rat/bovine cerebral mannose 6-phosphate receptors.

1990 • 4 citations