c-Ha-Ras mutants with point mutations in Gln-Val-Val region have reduced inhibitory activity toward cathepsin B

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

The ras protein family: evolutionary tree and role of conserved amino acids

1991 • 573 citations

Evolution of proteins of the cystatin superfamily

1990 • 297 citations

Mutational analysis of a ras catalytic domain.

1986 • 205 citations

The biochemistry of ras p21

1991 • 176 citations

Synthesis and expression of a synthetic gene for the activated human c-Ha-ras protein.

1986 • 83 citations

Cysteine proteinase inhibitors and rasgene products share the same biological activities including tranforming activity toward NIH3T3 mouse fibroblasts and the differentiation-inclucing activity toward PC12 rat pheochromocytoma cells

1990 • 58 citations

Activation of ras p21 transforming properties associated with an increase in the release rate of bound guanine nucleotide.

1986 • 53 citations

Transforming p21 ras protein: flexibility in the major variable region linking the catalytic and membrane-anchoring domains.

1985 • 49 citations

c‐Ha‐ras gene products are potent inhibitors of cathepsins B and L

1987 • 44 citations

A glutamic acid residue at position 31 of Ras protein is essential to the signal transduction for neurite outgrowth of PC12 cells and the stimulation of GTPase activity by GAPRas.

1992 • 29 citations

Inhibition of cathepsin L-induced degradation of epidermal growth factor receptors by c-Ha-ras gene products

1988 • 23 citations

Degradation of a cAMP-binding protein is inhibited by human c-Ha-ras gene products

1987 • 15 citations

Identification of amino acid residues of Ras protein that are essential for signal‐transducing activity but not for enhancement of GTPase activity by GAP

1991 • 13 citations

Recombinant Q53E- and Q53N--chicken egg white cystatin variants inhibit papain, actinidin and cathepsin B.

1991 • 5 citations

Cysteine Proteinase-Inhibitory Activity ofrasGene Product is not Affected by Mutations at GTPase-Activating Protein-Binding Sites

1989 • 5 citations