Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1

1988 • 887 citations

Growth factors and the regulation of bone remodeling.

1988 • 614 citations

Trafficking of lysosomal enzymes ¹

1987 • 497 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

Metalloproteinases and cancer invasion.

1990 • 399 citations

Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH.

1989 • 387 citations

Lysosomal Cathepsin B: Correlation with Metastatic Potential

1981 • 370 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides [published erratum appears in J Cell Biol 1989 Jun;108(6):following 2546]

1988 • 311 citations

The cystatins: a new class of peptidase inhibitors

1987 • 293 citations

Molecular mechanisms of bone resorption by the osteoclast

1989 • 262 citations

Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

1986 • 245 citations

Cathepsin B: association with plasma membrane in metastatic tumors.

1986 • 222 citations

Cysteine proteinases and metastasis

1984 • 211 citations

Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases.

1981 • 208 citations

MUTATION IN CYSTATIN C GENE CAUSES HEREDITARY BRAIN HAEMORRHAGE

1988 • 206 citations

Cathepsin B and cystatins: evidence for a role in cancer progression.

1990 • 206 citations

Lysosomal enzyme targeting

1990 • 205 citations

Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.

1982 • 200 citations

Expression of liver phenotypes in cultured mouse hepatoma cells: Synthesis and secretion of serum albumin

1973 • 171 citations

Inhibition of cysteine proteinases and dipeptidyl peptidase I by egg-white cystatin

1984 • 163 citations

Identification of latent procathepsins B and L in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro

1988 • 161 citations

Secretion of proteinases from malignant and nonmalignant human breast tissue.

1980 • 156 citations

Cystatin-like cysteine proteinase inhibitors from human liver

1984 • 152 citations

The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B

1988 • 139 citations

Kininogens revisited

1986 • 134 citations

Degradation of laminin by human tumor cathepsin B

1989 • 130 citations

Über die Proteasen der Magenschleimhaut. Erste Abhandlung über die Enzyme der Leukocyten.

1929 • 129 citations

Kinetics and temperature dependence of exposure of endocytosed material to proteolytic enzymes and low pH: Evidence for a maturation model for the formation of lysosomes

1987 • 126 citations

Biosyntheses and processing of lysosomal cysteine proteinases in rat macrophages

1988 • 121 citations

Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues.

1989 • 119 citations

Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinoma.

1991 • 109 citations

Cathepsin D in breast cancer

1990 • 106 citations

Biosynthesis of cathepsin B in cultured normal and I-cell fibroblasts.

1987 • 104 citations

Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane

1988 • 102 citations

Human Gastric Cathepsin E

1989 • 100 citations

Role of tumor cell glycoproteins immunologically related to glycoproteins Ib and IIb/IIIa in tumor cell‐platelet and tumor cell‐matrix interactions

1988 • 98 citations

Immunodetection of cathepsins b and l present in and secreted from human pre‐malignant and malignant colorectal tumour cell lines

1989 • 97 citations

Rapid inactivation of cathepsin L by Z-Phe-PheCHN2 and Z-Phe-AlaCHN2

1981 • 95 citations

Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages

1988 • 94 citations

Melanoma cell adhesion to basement membrane mediated by integrin-related complexes.

1989 • 92 citations

Recent Developments in Inhibiting Cysteine and Serine Proteases

1990 • 86 citations

New clue to Ras lipid glue

1989 • 86 citations

Membrane-associated cathepsin L: A role in metastasis of melanomas

1989 • 84 citations

Interrelationship of active and latent secreted human cathepsin B precursors

1986 • 82 citations

Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages

1989 • 79 citations

Mechanism for selective secretion of a lysosomal protease by transformed mouse fibroblasts

1989 • 79 citations

Properties of a plasma membrane-associated cathepsin B-like cysteine proteinase in metastatic B16 melanoma variants.

1987 • 73 citations

Plasma Membrane-Associated Cysteine Proteinases in Human and Animal Tumors

1987 • 65 citations

The subcellular localization of soluble and membrane-bound lysosomal enzymes in I-cell fibroblasts: a comparative immunocytochemical study.

1985 • 63 citations

A latent thiol proteinase from ascitic fluid of patients with neoplasia

1981 • 63 citations

Turnover of two lysosomal enzymes in macrophages.

1981 • 62 citations

Modulation of the transport of a lysosomal enzyme by PDGF.

1990 • 59 citations

A cysteine proteinase secreted from human breast tumours is immunologically related to cathepsin B

1982 • 58 citations

Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis

1988 • 57 citations

Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts.

1990 • 56 citations

Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma

1989 • 55 citations

Porcine spleen cathepsin B is an exopeptidase.

1986 • 52 citations

Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B.

1986 • 48 citations

Localization of cathepsin B in two human lung cancer cell lines.

1990 • 48 citations

Cathepsin B to cysteine proteinase inhibitor balance in metastatic cell subpopulations isolated from murine tumors.

1990 • 47 citations

A general framework of cysteine-proteinase mechanism deduced from studies on enzymes with structurally different analogous catalytic-site residues Asp-158 and −161 (papain and actinidin), Gly-196 (cathepsin B) and Asn-165 (cathepsin H). Kinetic studies up to pH 8 of the hydrolysis of N-α-benzyloxycarbonyl-<scp>l</scp>-arginyl-<scp>l</scp>-arginine 2-naphthylamide catalysed by cathepsin B and of <scp>l</scp>-arginine 2-naphthylamide catalysed by cathepsin H.

1985 • 47 citations

Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor.

1990 • 45 citations

Enhanced levels of cathepsin B mRNA in murine tumors

1989 • 45 citations

Studies of the biosynthesis of the mannose 6-phosphate receptor in receptor-positive and -deficient cell lines.

1983 • 42 citations

Cathepsin B-Like Proteinase as a Marker for Metastatic Tumor Cell Variants

1984 • 42 citations

Interaction of lysosomal cysteine proteinases with α2-macroglobulin: Conclusive evidence for the endopeptidase activities of cathepsins B and H

1989 • 41 citations

Involvement of a cathepsin B-like cysteine proteinase in platelet aggregation induced by tumor cells and their shed membrane vesicles

1983 • 40 citations

Cytochemical and biochemical evidence of cathepsin B in malignant, transformed and normal breast epithelial cells

1987 • 38 citations

Differences in cathepsin B mRNA levels in rat tissues ssuggest specialized functions

1986 • 37 citations

Peptidyl O-acyl hydroxamates: Potent new inactivators of cathepsin B

1988 • 36 citations

Peptidyl sulfonium salts. A new class of protease inhibitors.

1988 • 35 citations

Species variations amongst lysosomal cysteine proteinases

1984 • 35 citations

The glycosylation state of the precursors of the cathepsin B-like proteinase from human malignant ascitic fluid: Possible implication in the secretory pathway of these proenzymes

1989 • 30 citations

Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes

1985 • 30 citations

Endosomes can undergo an ATP-dependent density increase in the absence of dense lysosomes.

1990 • 29 citations

Cathepsin B-like activity in viable tumor cells isolated from rodent tumors.

1985 • 26 citations

Identification of cell surface cathepsin B-like activity on murine melanomas and fibrosarcomas: modulation by butanol extraction.

1988 • 24 citations

Processing of Endocytosed Material

1988 • 23 citations

Transient alterations in the expression of protease and extracellular matrix genes during metastatic lung colonization by H-ras-transformed 10T1/2 fibroblasts.

1990 • 18 citations

Mutation in the cystatin C gene causes hereditary brain hemorrhage.

1989 • 17 citations

Acid and neutral cysteine proteinase inhibitor in normal uterine portio and in squamo-epithelial metaplasia, dysplasias and infiltrative carcinoma of the uterine portio

1984 • 14 citations

[Pro-cathepsin D can activate in vitro pro-cathepsin B secreted by ovarian cancers].

1989 • 14 citations

The secretion of high molecular weight cathepsin B from cultured human liver cancers.

1989 • 11 citations

MUTATION IN THE CYSTATIN C GENE CAUSES HEREDITARY CYSTATINC AMYLOID ANGIOPATHY WITH CEREBRAL HEMORRHAGE

1988 • 11 citations

[Behavior of small molecular cysteine proteinase inhibitors in lung cancers and surrounding tissue].

1984 • 9 citations

Proteolysis of arterial basement membrane containing different amounts of carbohydrates

1986 • 7 citations

Das Verhalten der kleinmolekularen Cysteinproteinase-Inhibitoren in Lungencarcinomen und den sie umgebenden Geweben

1984 • 7 citations

Cathepsin B in cells of two rat sarcomas with different rates of spontaneous metastasis.

1989 • 6 citations

CATHEPSIN B: A PROTEINASE LINKED TO METASTASIS?

1986 • 5 citations

Biochemical aspects of cellular migration and invasion

1987 • 4 citations

High affinity binding of rat brain cathepsin B to purified rat/bovine cerebral mannose 6-phosphate receptors.

1990 • 4 citations

Deleted Work

1955 • 0 citations