Biosynthesis of lysosomal endopeptidases

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

1983 • 2,290 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

1980 • 743 citations

Trafficking of lysosomal enzymes ¹

1987 • 497 citations

Lysosomes : their role in protein breakdown

1987 • 435 citations

Cloning and sequence analysis of cDNA for human cathepsin D.

1985 • 318 citations

Mammalian Proteases : A Glossary and Bibliography

1986 • 299 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

Intracellular Protein Catabolism

1996 • 259 citations

Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution

1982 • 246 citations

Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

1986 • 245 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

Biosynthesis and transport of cathepsin D in cultured human fibroblasts.

1983 • 235 citations

Early events in the biosynthesis of the lysosomal enzyme cathepsin D.

1979 • 233 citations

Homology of amino acid sequences of rat liver cathepsins B and H with that of papain.

1983 • 231 citations

Macrophage endosomes contain proteases which degrade endocytosed protein ligands.

1985 • 223 citations

Aspartic proteinases and their inhibitors

1985 • 218 citations

Cysteine proteinases and metastasis

1984 • 211 citations

Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.

1982 • 200 citations

Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D.

1981 • 188 citations

Elastinolytic activity of human cathepsin L

1986 • 185 citations

The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L

1987 • 172 citations

Lysosomal Enzyme Precursors in Human Fibroblasts. Activation of Cathepsin D Precursor in vitro and Activity of beta-Hexosaminidase A Precursor towards Ganglioside GM2

1982 • 163 citations

Identification of latent procathepsins B and L in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro

1988 • 161 citations

Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts.

1987 • 151 citations

Transformation-dependent secretion of a low molecular weight protein by murine fibroblasts.

1978 • 149 citations

The major excreted protein of transformed fibroblasts is an activable acid-protease.

1986 • 147 citations

Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells.

1987 • 147 citations

Cloning and characterization of a mouse cysteine proteinase.

1986 • 137 citations

Structures and Functions of Lysosomal Thiol Proteinases and Their Endogenous Inhibitor

1983 • 135 citations

Golgi/granule processing of peptide hormone and neuropeptide precursors: A minireview

1984 • 134 citations

Cathepsin D isozymes from porcine spleens. Large scale purification and polypeptide chain arrangements.

1979 • 127 citations

Biosyntheses and processing of lysosomal cysteine proteinases in rat macrophages

1988 • 121 citations

Intracellular protein catabolism

1977 • 118 citations

Molecular cloning and sequencing of cDNA for rat cathepsin L

1987 • 115 citations

Calpain inhibition by peptide epoxides

1985 • 106 citations

Biosynthesis of cathepsin B in cultured normal and I-cell fibroblasts.

1987 • 104 citations

Isolation and sequence of a cDNA for human pro-(cathepsin L)

1988 • 98 citations

Carboxyl-terminal proteolytic processing during biosynthesis of the lysosomal enzymes .beta.-glucuronidase and cathepsin D

1983 • 95 citations

Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages

1988 • 94 citations

Amino acid sequences of the human kidney cathepsins H and L

1988 • 87 citations

Amino acid sequence of human liver cathepsin B

1985 • 82 citations

Identification of cDNA clones encoding a precursor of rat liver cathepsin B.

1985 • 73 citations

Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin

1987 • 73 citations

Characterization of a thiol proteinase secreted by malignant human breast tumours

1980 • 72 citations

Oligosaccharide units of lysosomal cathepsin D from porcine spleen. Amino acid sequence and carbohydrate structure of the glycopeptides.

1983 • 68 citations

Turnover of two lysosomal enzymes in macrophages.

1981 • 62 citations

Novel carbohydrate structures of cathepsin B from porcine spleen.

1984 • 58 citations

Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.

1986 • 58 citations

Biosynthesis and transport of lysosomal enzymes in human monocytes and macrophages. Effects of ammonium chloride, zymosan and tunicamycin

1983 • 58 citations

Molecular cloning and sequencing of cDNA for rat cathepsin H Homology in pro‐peptide regions of cysteine proteinases

1987 • 54 citations

Molecular forms of β-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes

1983 • 53 citations

An acid protease secreted by transformed cells interferes with antigen processing.

1988 • 50 citations

Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B.

1986 • 48 citations

Immunochemical Difference between Cathepsin D and Cathepsin E-Like Enzyme from Rat Spleen

1980 • 48 citations

Purification and amino acid sequence of chicken liver cathepsin L

1987 • 47 citations

The major ras induced protein in NIH3T3 cells is cathepsin L

1987 • 46 citations

Biosynthesis of lysosomal cathepsins B and H in cultured rat hepatocytes

1988 • 45 citations

Structural Studies on the Carbohydrate Moieties of Rat Liver Cathepsins B and H1

1985 • 41 citations

Differences in cathepsin B mRNA levels in rat tissues ssuggest specialized functions

1986 • 37 citations

Identification of a precursor form of cathepsin D in microsomal lumen: Characterization of enzymatic activation and proteolytic processing

1987 • 35 citations

Identification of latent procathepsin H in microsomal lumen: Characterization of proteolytic processing and enzyme activation

1988 • 30 citations

Postendocytic maturation of acid hydrolases: evidence of prelysosomal processing.

1987 • 28 citations

Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle

1983 • 25 citations

Sulfated oligosaccharides in human lysosomal enzymes

1987 • 23 citations

In vitro biosynthesis of the lysosomal cathepsin H

1987 • 17 citations

CATHEPSIN B: A PROTEINASE LINKED TO METASTASIS?

1986 • 5 citations

Some unexpected properties of cathepsin D

1985 • 1 citations