Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Hybridization of nucleic acids immobilized on solid supports

1984 • 1,357 citations

Plasmid screening at high colony density

1980 • 1,100 citations

Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries.

1985 • 818 citations

Synthetic oligonucleotide probes deduced from amino acid sequence data

1985 • 759 citations

Evolution of Proteolytic Enzymes

1984 • 641 citations

The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit β-globin DNA

1981 • 473 citations

Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein?

1984 • 337 citations

Human cathepsin B1. Purification and some properties of the enzyme

1973 • 322 citations

Cloning and sequence analysis of cDNA for human cathepsin D.

1985 • 318 citations

An alternative approach to deoxyoligonucleotides as hybridization probes by insertion of deoxyinosine at ambiguous codon positions.

1985 • 305 citations

Comparative biochemistry of the proteinases of eucaryotic microorganisms

1982 • 276 citations

Arylsulfonyltetrazoles, new coupling reagents and further improvements in the triester method for the synthesis of deoxyribooligonucleotides¹

1977 • 235 citations

Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product.

1982 • 235 citations

Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.

1983 • 232 citations

Homology of amino acid sequences of rat liver cathepsins B and H with that of papain.

1983 • 231 citations

Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.

1982 • 200 citations

Aleurain: a barley thiol protease closely related to mammalian cathepsin H.

1985 • 187 citations

Rapid synthesis of oligodeoxyribonucleotides VI. Effident, mechanised synthesis of heptadecadeoxyribonucleotides by an improved solid phase phosphotriester route

1981 • 185 citations

Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH

1984 • 153 citations

Structures and Functions of Lysosomal Thiol Proteinases and Their Endogenous Inhibitor

1983 • 135 citations

Use of a cDNA clone for the fourth component of human complement (C4) for analysis of a genetic deficiency of C4 in guinea pig.

1983 • 113 citations

Carboxyl-terminal proteolytic processing during biosynthesis of the lysosomal enzymes .beta.-glucuronidase and cathepsin D

1983 • 95 citations

Cathepsin B-related proteases in the insulin secretory granule.

1984 • 89 citations

Amino acid sequence of human liver cathepsin B

1985 • 82 citations

Construction of plasmid vectors with unique PstI cloning sites in a signal sequence coding region

1980 • 82 citations

A new and improved method for 3′-end labelling DNA using [α-32P]ddATP

1984 • 76 citations

Identification of cDNA clones encoding a precursor of rat liver cathepsin B.

1985 • 73 citations

A developmentally regulated cysteine proteinase in Dictyostelium discoideum.

1985 • 72 citations

Characterization of a latent cysteine proteinase from ascitic fluid as a high molecular weight form of cathepsin B

1983 • 67 citations

Novel carbohydrate structures of cathepsin B from porcine spleen.

1984 • 58 citations

Differential expression of mRNAs for alpha- and beta-tubulin during differentiation of the parasitic protozoan Leishmania mexicana.

1984 • 57 citations

Cathepsin B-Like Proteinase as a Marker for Metastatic Tumor Cell Variants

1984 • 42 citations

Identification of protease isozymes after analytical isoelectric focusing using fluorogenic substrates impregnated into cellulose membranes.

1984 • 41 citations

Molecular cloning of a bovine cathepsin

1985 • 38 citations

Primary structure study of rat liver cathepsin B -----A striking resemblance to papain

1980 • 37 citations

Species variations amongst lysosomal cysteine proteinases

1984 • 35 citations

Cathepsins J and K: High molecular weight cysteine proteinases from human tissues

1984 • 31 citations

Proteases in cellular slime mold development: evidence for their involvement.

1979 • 31 citations

Comparative studies of mouse liver cathepsin B and an analogous tumor thiol proteinase.

1983 • 31 citations

Proteolytic and other metabolic pathways in lysosomes

1984 • 28 citations

A comparison of four sulfhydryl cathepsins (B, C, H, and L) from porcine spleen

1984 • 14 citations