Regulation of class switch recombination of the immunoglobulin heavy chain genes

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

The double-strand-break repair model for recombination

1983 • 2,468 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Elevated recombination rates in transcriptionally active DNA

1989 • 1,666 citations

A mechanism for gene conversion in fungi

1964 • 1,459 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

1993 • 1,084 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1981 • 959 citations

A general model for genetic recombination.

1975 • 890 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

T Cell-Dependent B Cell Activation

1993 • 727 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Handbook of experimental immunology

1986 • 637 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

1993 • 565 citations

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

1980 • 562 citations

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

1992 • 536 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

IgG2a restriction of murine antibodies elicited by viral infections.

1987 • 429 citations

Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and α genes

1982 • 421 citations

Cytokine regulation of T-cell function: potential for therapeutic intervention

1993 • 412 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

1992 • 409 citations

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

1986 • 405 citations

Molecular components of the B-cell antigen receptor complex of the IgM class

1990 • 401 citations

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.

1989 • 394 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

A three-tiered view of the role of IgA in mucosal defense

1993 • 374 citations

Signal transduction by Fc receptors: the Fc&RI case

1993 • 373 citations

Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.

1990 • 353 citations

Human Immunoglobulin Heavy Chain Genes Map to a Region of Translocations in Malignant B Lymphocytes

1982 • 351 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

1982 • 323 citations

SINGLE CELL STUDIES ON 19S ANTIBODY PRODUCTION

1964 • 317 citations

Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte

1977 • 309 citations

IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

1988 • 308 citations

The B-cell antigen receptor of the five immunoglobulin classes

1991 • 302 citations

ANTIBODY FORMATION

1963 • 290 citations

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

1988 • 285 citations

Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching

1988 • 277 citations

DNA sequences at immunoglobulin switch region recombination sites

1993 • 275 citations

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1994 • 267 citations

Production and Activities of IgE in Helminth Infection

2015 • 265 citations

Cre-stimulated recombination atloxP-containing DNA sequences placed into the mammalian genome

1989 • 262 citations

Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.

1987 • 259 citations

Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens.

1992 • 258 citations

CD40 ligand and its role in X-linked hyper-IgM syndrome

1993 • 257 citations

B lymphocyte differentiation induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classes.

1975 • 250 citations

Circular DNA is excised by immunoglobulin class switch recombination

1990 • 244 citations

DNA Sequences Mediating Class Switching in α-Immunoglobulins

1980 • 243 citations

Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching

1990 • 240 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region

1990 • 237 citations

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.

1993 • 237 citations

Correlation between segmental flexibility and effector function of antibodies

1984 • 235 citations

Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon

1985 • 232 citations

Structure of human immunoglobulin gamma genes: implications for evolution of a gene family

1982 • 231 citations

Pleiotropy and redundancy: T cell-derived lymphokines in the immune response

1989 • 228 citations

Activation of mouse complement by monoclonal mouse antibodies

1981 • 226 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

1986 • 220 citations

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

1990 • 220 citations

Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes

1981 • 219 citations

Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.

1993 • 218 citations

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

1994 • 214 citations

Sequential Expression of Immunoglobulin on Developing Mouse B Lymphocytes: A Systematic Survey That Suggests a Model for the Generation of Immunoglobulin Isotype Diversity

1978 • 211 citations

Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40.

1994 • 210 citations

B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex.

1990 • 208 citations

Immunoglobulin class switching

1984 • 208 citations

Fundamental Immunology

1990 • 207 citations

A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

1993 • 206 citations

Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue

1986 • 205 citations

Circular DNA is a product of the immunoglobulin class switch rearrangement

1990 • 202 citations

Activation of mouse complement by different classes of mouse antibody.

1979 • 184 citations

Mechanism for transforming growth factor beta and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures.

1990 • 183 citations

A NEW MOUSE IMMUNOGLOBULIN: I<scp>G</scp>G3

1971 • 181 citations

SEQUENCES OF SYNTHESIS OF γ-1 MACROGLOBULIN AND γ-2 GLOBULIN ANTIBODIES DURING PRIMARY AND SECONDARY RESPONSES TO PROTEINS, SALMONELLA ANTIGENS, AND PHAGE

1963 • 173 citations

Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences

1981 • 173 citations

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

1982 • 173 citations

Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma.

1989 • 172 citations

The role of gene deletion in the immunoglobulin heavy chain switch

1980 • 164 citations

Virally induced modulation of murine IgG antibody subclasses.

1988 • 162 citations

Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells.

1993 • 162 citations

Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.

1982 • 157 citations

NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation.

1993 • 151 citations

Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines.

1990 • 150 citations

Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms

1981 • 143 citations

Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen.

1992 • 143 citations

Rescue from anti-IgM-induced programmed cell death by the B cell surface proteins CD20 and CD40

1992 • 142 citations

Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

1975 • 139 citations

The mouse IgH 3′‐enhancer

1991 • 139 citations

Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

1990 • 138 citations

B Lymphocyte Differentiation Induced by Lipopolysaccharide

1975 • 138 citations

Structure and expression of germ line immunoglobulin gamma 2b transcripts.

1988 • 136 citations

Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4.

1989 • 134 citations

Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1.

1990 • 123 citations

Mouse Immunoglobulin D: Messenger RNA and Genomic DNA Sequences

1980 • 123 citations

An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing

1980 • 121 citations

Gene conversion and polymorphism: Generation of mouse immunoglobulin γ2a chain alleles by differential gene conversion by γ2b chain gene

1983 • 119 citations

An enhancer at the 3′ end of the mouse immunoglobulin heavy chain locus

1991 • 116 citations

Immunoglobulin Class Switch Recombination

1993 • 116 citations

Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.

1991 • 115 citations

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.

1993 • 114 citations

Modulation of IL-4 induced germline ε RNA synthesis in human B cells by tumor necrosis factor-α, anti-CD40 monoclonal antibodies or transforming growth factor-β correlates with levels of IgE production

1992 • 112 citations

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus

1993 • 112 citations

Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon.

1990 • 111 citations

Complete physical map of the human immunoglobulin heavy chain constant region gene complex.

1989 • 109 citations

Synthesis of Multiple Immunoglobulin Classes by Single Lymphocytes

1977 • 109 citations

The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence.

1982 • 108 citations

Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE.

1992 • 108 citations

Complete nucleotide sequence of mouse imunoglobulin μ gene and comparison with other immunoglobulin heavy chain genes

1980 • 108 citations

Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression

1980 • 106 citations

Modification of B Lymphocyte Differentiation by Anti-Immunoglobulins

1974 • 106 citations

The murine IgG₁/IgE class switch program

1992 • 105 citations

Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

1983 • 105 citations

The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface.

1990 • 101 citations

Mouse IgA heavy chain gene sequence: implications for evolution of immunoglobulin hinge axons.

1981 • 99 citations

Gene segments encoding transmembrane carboxyl termini of immunoglobulin γ chains

1981 • 99 citations

Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.

1981 • 99 citations

Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes.

1985 • 99 citations

Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer.

1992 • 98 citations

Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome

1980 • 98 citations

Isolation, structure and expression of cDNA and genomic clones for murine eosinophil differentiation factor

1988 • 96 citations

Molecular aspects of heavy-chain class switching.

1989 • 95 citations

Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts.

1986 • 95 citations

Directed Ig class switch recombination in activated murine B cells.

1987 • 94 citations

Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains.

1980 • 93 citations

Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements.

1992 • 93 citations

Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes

1990 • 91 citations

Germline transcripts of the murine immunoglobulin _γ2a gene: structure and induction by IFN-_γ

1993 • 91 citations

Antibodies of the secondary response can be expressed without switch recombination in normal mouse B cells.

1984 • 88 citations

Regulation of the β-globin locus

1993 • 88 citations

Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokine(s).

1984 • 87 citations

Effect of transforming growth factor (TGF)-beta 1 on IgA isotype expression. TGF-beta 1 induces a small increase in sIgA+ B cells regardless of the method of B cell activation.

1992 • 86 citations

Humoral immune functions in IL-4 transgenic mice.

1991 • 86 citations

A model for the molecular requirements of immunoglobulin heavy chain class switching

1982 • 85 citations

Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype.

1975 • 84 citations

T helper cell‐dependent B cell activation

1991 • 84 citations

A processed human immunoglobulin epsilon gene has moved to chromosome 9.

1982 • 84 citations

Transplantation Immunity and Tolerance

1961 • 83 citations

Nucleotide sequence divergence of mouse immunoglobulin gamma 1 and gamma 2b chain genes and the hypothesis of intervening sequence-mediated domain transfer.

1980 • 82 citations

Regulation of Ig Class Secretion by Soluble Products of Certain T‐Cell Lines

1984 • 81 citations

The carbohydrates of mouse hepatitis virus (MHV) A59: structures of the O-glycosidically linked oligosaccharides of glycoprotein E1.

1984 • 78 citations

Ig mu-epsilon isotype switch in IL-4-treated human B lymphoblastoid cells. Evidence for a sequential switch.

1992 • 77 citations

Expression of I_μ-C_γ hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching

1994 • 77 citations

B cell differentiation induced by lipopolysaccharide. V. Suppression of plasma cell maturation by anti-mu: mode of action and characteristics of suppressed cells.

1978 • 76 citations

Structure and expression of germline immunoglobulin γ³ heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching

1990 • 76 citations

Production of sterile transcripts of C_γ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells

1989 • 74 citations

Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences.

1992 • 74 citations

Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells.

1991 • 74 citations

Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene.

1991 • 73 citations

Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4.

1990 • 72 citations

Switch region content of hybridomas: the two spleen cell Igh loci tend to rearrange to the same isotype.

1987 • 71 citations

DNA regions flanking the mouse Ig 3' alpha enhancer are differentially methylated and DNAase I hypersensitive during B cell differentiation.

1993 • 71 citations

Frequency of immunoglobulin E class switching is autonomously determined and independent of prior switching to other classes.

1994 • 70 citations

Partial biochemical characterization of IgG₁‐inducing factor

1985 • 69 citations

Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line.

1981 • 67 citations

B lymphocyte activation: Entry into cell cycle is accompanied by decreased expression of IgD but not IgM

1983 • 66 citations

Isolation of myeloma variants with predefined variant surface immunoglobulin by cell sorting.

1978 • 65 citations

A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation.

1989 • 65 citations

LR1, a lipopolysaccharide-responsive factor with binding sites in the immunoglobulin switch regions and heavy-chain enhancer.

1991 • 65 citations

Complete nucleotide sequence of the murine gamma 3 switch region and analysis of switch recombination sites in two gamma 3-expressing hybridomas.

1985 • 65 citations

A nuclear DNA-binding protein expressed during early stages of B cell differentiation interacts with diverse segments within and 3' of the Ig H chain gene cluster.

1992 • 64 citations

Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice

1994 • 62 citations

Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3′ enhancer

1992 • 61 citations

Structure of TGF-β1-induced human immunoglobulin Cα1 and Cα2 germ-line transcripts

1991 • 61 citations

Deletion of Cmu genes in mouse B lymphocytes upon stimulation with LPS.

1983 • 60 citations

Control of Immunoglobulin Class Switch Recombination

1986 • 60 citations

Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.

1987 • 59 citations

Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch.

1988 • 57 citations

Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide.

1992 • 57 citations

Isotype switching in murine pre-B cell lines

1983 • 55 citations

Copy choice mechanism of immunoglobulin heavy-chain switch recombination.

1990 • 52 citations

Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes.

1990 • 51 citations

Activation to IgG Secretion by Lipopolysaccharide Requires Several Proliferation Cycles

1979 • 50 citations

Switch recombination breakpoints are strictly correlated with DNA recognition motifs for immunoglobulin S gamma 3 DNA-binding proteins.

1992 • 49 citations

Characterization of the IgG Response Induced by Polyclonal B Cell Activators

1982 • 47 citations

Cell-specific expression of secreted versus membrane forms of immunoglobulin gamma 2b mRNA involves selective use of alternate polyadenylation sites.

1985 • 46 citations

Isotype switching in human B lymphocyte malignancies occurs by DNA deletion: evidence for nonspecific switch recombination.

1987 • 46 citations

Ig isotype switching in B lymphocytes. The effect of T cell-derived interleukins, cytokines, cholera toxin, and antigen on isotype switch frequency of a cloned B cell lymphoma

1991 • 46 citations

IL-4 induces the specific rearrangement of gamma 1 genes on the expressed and unexpressed chromosomes of lipopolysaccharide-activated normal murine B cells.

1989 • 45 citations

An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion.

1992 • 43 citations

Production of RNA for secreted immunoglobulin μ chains does not require transcriptional termination 5′ to the μM exons

1983 • 42 citations

T helper cells

1992 • 42 citations

Properties of B cell stage specific and ubiquitous nuclear factors binding to immunoglobulin heavy chain gene switch regions

1992 • 42 citations

Interleukin 5 induces S mu-S gamma 1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: a three component model for Ig class switching.

1993 • 39 citations

The human l_α1 and l_α2 germline promoter elements: proximal positive and distal negative elements may regulate the tissue specific expression of C_α1 and C_α2 germline transcripts

1993 • 39 citations

Effect of downregulation of germline transcripts on immunoglobulin A isotype differentiation.

1993 • 39 citations

Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line.

1984 • 39 citations

Cloning and nucleotide sequence of mouse immunoglobulin epsilon chain cDNA.

1982 • 38 citations

Concerted evolution of the mouse immunoglobulin gamma chain genes.

1984 • 35 citations

The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints.

1993 • 31 citations

Molecular requirements for immunoglobulin heavy chain constant region gene switch recombination revealed with switch substrate retroviruses

1989 • 30 citations

A common mechanism for the synthesis of membrane and secreted immunoglobulin α, γ and μ chains

1982 • 30 citations

The immunoglobulin heavy chain switch: structural features of gamma 1 recombinant switch regions.

1987 • 29 citations

Intraclonal diversification in immunoglobulin isotype secretion: an analysis of switch probabilities.

1982 • 28 citations

Sites of switch recombination in IgG2b- and IgG2a-producing hybridomas.

1988 • 28 citations

Products and implied mechanism of H chain switch recombination.

1989 • 23 citations

Isotype restriction during infection of mice with the cestode Mesocestoides corti: role of immune suppression.

1987 • 22 citations

Coexpression of mu and gamma 1 heavy chains can occur by a discontinuous transcription mechanism from the same unrearranged chromosome.

1992 • 22 citations

The contribution of parasite-specific T cells to isotype restriction in Mesocestoides corti-infected mice.

1987 • 21 citations

The molecular events in heavy chain class-switching.

1989 • 21 citations

Patterns and extent of isotype-specificity in the murine H chain switch DNA rearrangement.

1990 • 20 citations

RNA splicing generates alternate forms of germline immunoglobulin α heavy chain transcripts

1990 • 18 citations

Developmental regulation of membrane and secretory Ig gamma 2b mRNA.

1989 • 18 citations

Nuclear protein binding to octamer motifs in the immunoglobulin γ1 switch region

1991 • 17 citations

Long identical repeats in the mouse gamma 2b switch region and their implications for the mechanism of class switching.

1984 • 16 citations

Rearrangement of Rat Immunoglobulin E heavy-chain and c-myc Genes in the B-Cell Immunocytoma IR162

1987 • 10 citations

Trancriptional regulation of IgM and Ig

1985 • 9 citations

DNA binding sites 5′ of the IgG1 switch region comprising IL4 inducibility and B cell specificity

1992 • 8 citations

Rearrangement of rat immunoglobulin E heavy-chain and c-myc genes in the B-cell immunocytoma IR162.

1987 • 7 citations