Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences.

Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid

1978 • 4,472 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

1988 • 1,734 citations

Elevated recombination rates in transcriptionally active DNA

1989 • 1,666 citations

Monovalent cation-induced structure of telomeric DNA: The G-quartet model

1989 • 1,202 citations

Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops

1989 • 939 citations

A sodium-potassium switch in the formation of four-stranded G4-DNA

1990 • 789 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine·guanine base pairs

1987 • 675 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

V(D)J recombination: a functional definition of the joining signals.

1989 • 467 citations

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1989 • 432 citations

Coding potential and regulatory signals of the polyoma virus genome

1980 • 369 citations

The integration host factor stimulates interaction of RNA polymerase with NIFA, the transcriptional activator for nitrogen fixation operons

1990 • 367 citations

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

1987 • 346 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

The DNA binding domain and bending angle of E. coli CAP protein

1986 • 322 citations

Recombination-stimulating sequences in yeast ribosomal DNA correspond to sequences regulating transcription by RNA polymerase I

1987 • 317 citations

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

1988 • 285 citations

Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching

1988 • 277 citations

Powerful and versatile enhancer-promoter unit for mammalian expression vectors

1986 • 263 citations

Circular DNA is excised by immunoglobulin class switch recombination

1990 • 244 citations

Cis-acting, recombination-stimulating activity in a fragment of the ribosomal DNA of S. cerevisiae

1984 • 243 citations

Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching

1990 • 240 citations

The role of DNA topoisomerases in recombination and genome stability: A double-edged sword?

1990 • 236 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Circular DNA is a product of the immunoglobulin class switch rearrangement

1990 • 202 citations

[6] The use of pKC30 and its derivatives for controlled expression of genes

1983 • 202 citations

Developmental stage specificity of the lymphoid V(D)J recombination activity.

1987 • 199 citations

Novel strand exchanges in V(D)J recombination

1988 • 174 citations

Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma.

1989 • 172 citations

MECHANISM AND DEVELOPMENTAL PROGRAM OF IMMUNOGLOBULIN GENE REARRANGEMENT IN MAMMALS

1989 • 144 citations

Role of integration host factor in the regulation of the glnHp2 promoter of Escherichia coli.

1991 • 140 citations

Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

1990 • 138 citations

Escherichia coli integration host factor bends the DNA at the ends of IS1 and in an insertion hotspot with multiple IHF binding sites.

1987 • 137 citations

Structure and expression of germ line immunoglobulin gamma 2b transcripts.

1988 • 136 citations

Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4.

1989 • 134 citations

Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon.

1990 • 111 citations

The NF-ϰB transcription factor induces DNA bending which is modulated by its 65-kD subunit

1990 • 109 citations

The γδ resolvase induces an unusual DNA structure at the recombinational crossover point

1987 • 107 citations

Sex, maps, and imprinting

1991 • 78 citations

Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation.

1991 • 77 citations

Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4.

1990 • 72 citations

Complete nucleotide sequence of the murine gamma 3 switch region and analysis of switch recombination sites in two gamma 3-expressing hybridomas.

1985 • 65 citations

V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.

1990 • 64 citations

Deletion of Cmu genes in mouse B lymphocytes upon stimulation with LPS.

1983 • 60 citations

DNA bending is induced in an enhancer by the DNA-binding domain of the bovine papillomavirus E2 protein.

1988 • 55 citations

Transfer and Expression of Plasmids Containing Human Cytomegalovirus Immediate‐Early Gene 1 Promoter‐Enhancer Sequences in Eukaryotic and Prokaryotic Cells

1988 • 54 citations

Palindromic sequences are associated with sites of DNA breakage during gene conversion

1986 • 51 citations

Structure and Expression of Germ Line Immunoglobulin γ2b Transcripts

1988 • 36 citations

Structure and Expression of Germ Line Immunoglobulin Heavy-Chain ε Transcripts: Interleukin-4 Plus Lipopolysaccharide-Directed Switching to Cε

1990 • 33 citations

Coordination of Immunoglobulin DJ_H Transcription and D-to-J_H Rearrangement by Promoter-Enhancer Approximation

1991 • 26 citations