Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

[31] Electron microscope heteroduplex methods for mapping regions of base sequence homology in nucleic acids

1971 • 1,605 citations

The use of thin acrylamide gels for DNA sequencing

1978 • 1,449 citations

Spliced segments at the 5′ terminus of adenovirus 2 late mRNA

1977 • 1,301 citations

An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA

1977 • 1,138 citations

Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

1978 • 1,117 citations

The Genome of Simian Virus 40

1978 • 948 citations

THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULE

1969 • 869 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

The rabbit β-globin gene contains a large insert in the coding sequence

1977 • 422 citations

Mapping of Deletions and Substitutions in Heteroduplex DNA Molecules of Bacteriophage Lambda by Electron Microscopy

1969 • 408 citations

Ovalbumin gene is split in chicken DNA

1977 • 396 citations

Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution

1973 • 381 citations

Packaging recombinant DNA molecules into bacteriophage particles in vitro.

1977 • 343 citations

The structural organization of ribosomal DNA in drosophila melanogaster

1977 • 342 citations

Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o.

1977 • 339 citations

Transcription and processing of intervening sequences in yeast tRNA genes

1978 • 332 citations

R loop mapping of the 18S and 28S sequences in the long and short repeating units of drosophila melanogaster rDNA

1977 • 305 citations

A novel arrangement of the 18S and 28S sequences in a repeating unit of drosophila melanogaster rDNA

1977 • 271 citations

THE EVOLUTIONARY ORIGINS OF THE IMMUNOGLOBULINS

1966 • 258 citations

Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.

1978 • 254 citations

The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.

1978 • 242 citations

Structure of yeast phenylalanine-tRNA genes: an intervening DNA segment within the region coding for the tRNA.

1978 • 231 citations

Antibody Active Sites and Immunoglobulin Molecules

1966 • 221 citations

Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart.

1977 • 193 citations

Comparison of cloned rabbit and mouse β-globin genes showing strong evolutionary divergence of two homologous pairs of introns

1978 • 156 citations

Structure and processing of yeast precursor tRNAs containing intervening sequences

1978 • 149 citations

Nucleotide sequence homology at 12 intron–exon junctions in the chick ovalbumin gene

1978 • 145 citations

Cloning of an immunoglobulin variable region gene from mouse embryo.

1977 • 123 citations

Molecular analysis of spontaneous somatic mutants

1977 • 120 citations

Structure at 4.5 Å; Resolution of a Phosphorylcholine-binding Fab

1973 • 113 citations

DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats.

1978 • 98 citations

The presence of ovalbumin mRNA coding sequences in multiple restriction fragments of chicken DNA

1977 • 91 citations

Improved derivative of a phage λ EK2 vector for cloning recombinant DNA

1976 • 85 citations

Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes

1978 • 80 citations

Structural Variants of Human and Murine Immunoglobulins

1975 • 71 citations

Synthesis of a carboxyl-terminal (constant region) fragment of the immunoglobin light chain by a mouse myeloma cell line

1974 • 68 citations

Cloned MPC 11 myeloma cells express two kappa genes: a gene for a complete light chain and a gene for a constant region polypeptide

1977 • 51 citations

Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.

1978 • 31 citations