The role of gene deletion in the immunoglobulin heavy chain switch

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A membrane-filter technique for the detection of complementary DNA

1966 • 3,996 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

Enhanced autoradiographic detection of ³²P and ¹²⁵I using intensifying screens and hypersensitized film

1977 • 947 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

1976 • 726 citations

A physical map of the DNA regions flanking the rabbit β-globin gene

1977 • 654 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

1978 • 419 citations

The molecular basis of antibody formation: a paradox.

1965 • 394 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells

1978 • 324 citations

Organization of immunoglobulin heavy chain genes and allelic deletion model.

1978 • 297 citations

The arrangement and rearrangement of antibody genes

1978 • 277 citations

Rearrangement of genetic information may produce immunoglobulin diversity

1978 • 209 citations

Evidence for Control of Synthesis of the Variable Regions of the Heavy Chains of Immunoglobulins G and M by the Same Gene

1970 • 182 citations

Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.

1979 • 131 citations

Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis.

1978 • 129 citations

GENETICS OF ANTIBODIES

1968 • 124 citations

Synthesis of Multiple Immunoglobulin Classes by Single Lymphocytes

1977 • 109 citations

Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype.

1975 • 84 citations

Variants of Mouse Myeloma Cells That Produce Short Immunoglobulin Heavy Chains

1974 • 76 citations

Evidence for splicing of interrupted immunoglobulin variable and constant region sequences in nuclear RNA

1978 • 71 citations

Structural evidence for independent joining region gene in immunoglobulin heavy chains from anti-galactan myeloma proteins and its potential role in generating diversity in complementarity-determining regions

1979 • 71 citations

Studies of Generation of B-cell Diversity in Mouse, Man, and Chicken

1977 • 70 citations

Distribution of allotypic specificities A1, A2, A14, and A15 among immunoglobulin G molecules.

1970 • 68 citations

Isolation of myeloma variants with predefined variant surface immunoglobulin by cell sorting.

1978 • 65 citations

Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNA

1978 • 63 citations

Biosynthesis of immunoglobulins

1972 • 58 citations

Association of allotypic specificities of group a with allotypic specificities A11 and A12 in rabbit immunoglobulin

1970 • 58 citations

Distribution of Allotypic Specificities A1, A2, A14, and A15 Among Immunoglobulin G Molecules

1970 • 54 citations

Antibody differentiation: apparent sequence identity between variable regions shared by IgA and IgG immunoglobulins.

1976 • 43 citations

Surface Markers and Functional Relationships of Cells Involved in Murine B-lymphocyte Differentiation

1977 • 43 citations

Nuclear Transcripts of Mouse Heavy Chain Immunoglobulin Genes Contain Only the Expressed Class of C-Region Sequences

1979 • 37 citations

Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination.

1979 • 36 citations

Primary and secondary variants in immunoglobulin heavy chain production

1976 • 31 citations

Mutual homology of mouse immunoglobulin .gamma.-chain gene sequences

1979 • 29 citations

Variable and constant regions are separated in the 10-kbase transcription unit coding for immunoglobulin kappa light chains.

1978 • 27 citations