Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

1983 • 490 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

Transgenic Mice and Analysis of B-Cell Tolerance

1992 • 362 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody

1984 • 304 citations

Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ

1987 • 293 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Human Antibody Effector Function

1992 • 266 citations

The Role of Somatic Mutation in the Pathogenic Anti-DNA Response

1992 • 244 citations

Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line

1985 • 244 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Characterization of a human colon/lung carcinoma oncogene

1983 • 208 citations

Immunoglobulin class switching

1984 • 208 citations

All T15 Id-positive antibodies (but not the majority of V_HT15⁺ antibodies) are produced by peritoneal CD5⁺ B lymphocytes

1990 • 197 citations

Induction of Plasma Cell Tumours in BALB/c Mice with 2,6,10,14-Tetramethylpentadecane (Pristane)

1969 • 196 citations

Isotypes and specificities of immunoglobulins produced by germ‐free mice fed chemically defined ultrafiltered “antigen‐free” diet

1984 • 194 citations

A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes

1985 • 169 citations

Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse

1989 • 157 citations

The Generation of Diversity in Phosphorylcholine-Binding Antibodies

1984 • 153 citations

Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen.

1992 • 147 citations

Immunological regulation of spontaneous antibodies to DNA and RNA. II. Sequential switch from IgM to IgG in NZB/NZW F1 mice.

1977 • 145 citations

Clonal Deletion of Autospecific B Lymphocytes

1991 • 137 citations

Monoclonal vs. heterogeneous anti‐H‐8 antibodies in the analysis of the anti‐phosphorylcholine response in BALB/c mice

1981 • 127 citations

Characterization of the antibody to the C-carbohydrate produced by a transplantable mouse plasmacytoma

1969 • 122 citations

Monoclonal anti‐allotype antibody towards BALB/c IgM Analysis of specificity and site of a V‐C crossover in recombinant strain BALB‐Igh‐V^a/Igh‐C^b

1987 • 104 citations

Layered Evolution in the Immune System

1992 • 99 citations

Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes

1990 • 91 citations

A monoclonal antibody against Igh6-4 determinant

1986 • 88 citations

Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice.

1989 • 71 citations

Natural occurrence and origin of somatically mutated memory B cells in mice.

1992 • 71 citations

Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies.

1988 • 66 citations

Rat anti-T15 monoclonal antibodies with specificity for VH and VH-VL epitopes

1984 • 57 citations

Genetic regulation of the class conversion of dsDNA-specific antibodies in (NZB � NZW)F1 hybrid

1983 • 55 citations

Somatically mutated IgG anti‐DNA antibody clonally related to germ‐line encoded IgM anti‐DNA antibody

1992 • 48 citations

T Cell‐Dependent Antibody Production by Ly‐1 B Cells^a

1992 • 46 citations

Alternative expression of secreted and membrane forms of immunoglobulin mu-chain is regulated by transcriptional termination in stable plasmacytoma transfectants.

1988 • 42 citations

Selection of Autoantibody Specificities in the Ly‐1 B Subset^a

1992 • 17 citations