The chemistry and biology of fatty acid, polyketide, and nonribosomal peptide biosynthesis

FATTY ACID SYNTHESIS AND ITS REGULATION

1983 • 1,007 citations

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

1991 • 883 citations

Structural basis of substrate specificity in the serine proteases

1995 • 802 citations

Fatty acid synthase, a proficient multifunctional enzyme

1989 • 801 citations

MOLECULAR GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY ACID BIOSYNTHESIS

1990 • 674 citations

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

1990 • 611 citations

The animal fatty acid synthase: one gene, one polypeptide, seven enzymes

1994 • 585 citations

Biochemistry (4th edn)

1995 • 579 citations

Regulation of fatty acid biosynthesis in Escherichia coli

1993 • 578 citations

Engineered Biosynthesis of Novel Polyketides

1993 • 459 citations

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

1995 • 436 citations

Crystal Structure and Function of the Isoniazid Target of Mycobacterium tuberculosis

1995 • 419 citations

POLYKETIDE SYNTHESIS: Prospects for Hybrid Antibiotics

1993 • 369 citations

Enoyl-Acyl Carrier Protein Reductase (fabI) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli

1995 • 360 citations

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

1984 • 358 citations

A Nonribosomal System of Peptide Biosynthesis

1996 • 344 citations

Rational Design of Peptide Antibiotics by Targeted Replacement of Bacterial and Fungal Domains

1995 • 336 citations

The Filamentous fungi

1975 • 323 citations

Nonribosomal biosynthesis of peptide antibiotics

1990 • 322 citations

The multifunctional 6‐methylsalicylic acid synthase gene of Penicillium patulum

1990 • 301 citations

Sequence and analysis of the genetic locus responsible for surfactin synthesis in Bacillus subtilis

1993 • 296 citations

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

1995 • 286 citations

The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame

1994 • 256 citations

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

1989 • 250 citations

Repositioning of a Domain in a Modular Polyketide Synthase to Promote Specific Chain Cleavage

1995 • 250 citations

Gramicidin S biosynthesis operon containing the structural genes grsA and grsB has an open reading frame encoding a protein homologous to fatty acid thioesterases

1989 • 244 citations

POLYKETIDE SYNTHASE GENE MANIPULATION: A Structure-Function Approach in Engineering Novel Antibiotics

1995 • 242 citations

Regulation of fatty acid biosynthesis in Escherichia coli.

1993 • 241 citations

The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes.

1990 • 240 citations

Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate‐forming enzymes

1992 • 240 citations

The polyketide metabolites

1992 • 235 citations

Engineered Biosynthesis of a Complete Macrolactone in a Heterologous Host

1994 • 229 citations

Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.

1992 • 229 citations

Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

1989 • 226 citations

Unified stereochemical model of polyether antibiotic structure and biogenesis

1983 • 221 citations

X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

1993 • 217 citations

Cloning, Overproduction, and Characterization of the Escherichia coli Holo-acyl Carrier Protein Synthase

1995 • 213 citations

Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate‐forming enzymes

1992 • 205 citations

Acetyl Coenzyme A Carboxylase System of Escherichia coli

1974 • 204 citations

Theoretical Study of the Absorption and Emission Spectra of Indole in the Gas Phase and in a Solvent

1996 • 203 citations

Molecular characterization of the enniatin synthetase gene encoding a multifunctional enzyme catalysing N‐methyldepsipeptide formation in Fusarium scirpi

1993 • 186 citations

Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics

1990 • 184 citations

The multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421,073 dalton protein similar to Bacillus brevis peptide antibiotic synthetases.

1990 • 184 citations

An erythromycin analog produced by reprogramming of polyketide synthesis.

1993 • 183 citations

Biosynthese von 6‐Methylsalicylsäure

1970 • 183 citations

Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

1992 • 182 citations

Modular structure of genes encoding multifunctional peptide synthetases required for non-ribosomal peptide synthesis

1995 • 178 citations

Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor

1988 • 178 citations

The role of cysteines in polyketide synthases. Site-directed mutagenesis of resveratrol and chalcone synthases, two key enzymes in different plant-specific pathways

1991 • 175 citations

The Escherichia coli Malonyl-CoA:Acyl Carrier Protein Transacylase at 1.5-Å Resolution.

1995 • 174 citations

Fatty acid metabolism and its regulation

1984 • 172 citations

A small gene, designated comS, located within the coding region of the fourth amino acid‐activation domain of srfA, is required for competence development in Bacillus subtilis

1995 • 172 citations

Modular Structure of Peptide Synthetases Revealed by Dissection of the Multifunctional Enzyme GrsA

1995 • 172 citations

Acetoacetyl-acyl carrier protein synthase, a potential regulator of fatty acid biosynthesis in bacteria.

1987 • 172 citations

Struktur und Biogenese der Makrolide

1957 • 171 citations

The gene encoding Escherichia coli acyl carrier protein lies within a cluster of fatty acid biosynthetic genes.

1992 • 166 citations

Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase

1995 • 165 citations

Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase

1994 • 165 citations

Molecular analysis of chalcone and dihydropinosylvin synthase from Scots pine (Pinus sylvestris), and differential regulation of these and related enzyme activities in stressed plants

1992 • 159 citations

Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.

1989 • 159 citations

Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions

1990 • 157 citations

A Family of Protein-Cutting Proteins

1974 • 157 citations

Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis.

1994 • 155 citations

Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.

1994 • 152 citations

Nonribosomal polypeptide synthesis on polyenzyme templates

1973 • 145 citations

Macrolide biosynthesis. 4. Intact incorporation of a chain-elongation intermediate into erythromycin.

1987 • 144 citations

Purification and properties of a stilbene synthase from induced cell suspension cultures of peanut.

1984 • 143 citations

Reaction Mechanisms of Homodimeric Plant Polyketide Synthases (Stilbene and Chalcone Synthase)

1995 • 140 citations

An active serine is involved in covalent substrate amino acid binding at each reaction center of gramicidin S synthetase.

1991 • 139 citations

Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin‐producing polyketide synthase from Saccharopolyspora erythraea

1992 • 137 citations

Acetoacetyl-acyl carrier protein synthase

1989 • 137 citations

Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits.

1981 • 134 citations

Die biochemischen Grundlagen der „Polyacetat‐Regel”︁

1961 • 124 citations

Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence.

1988 • 121 citations

Evidence for a double-helical structure for modular polyketide synthases

1996 • 119 citations

Enniatin synthetase, a novel type of multifunctional enzyme catalyzing depsipeptide synthesis in Fusarium oxysporum

1982 • 117 citations

Analysis of core sequences in the D-Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis

1994 • 117 citations

Primary structure of chicken liver acetyl-CoA carboxylase deduced from cDNA sequence.

1988 • 115 citations

Enzymatic Synthesis of a Bacterial Polyketide from Acetyl and Malonyl Coenzyme A

1993 • 113 citations

Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases

1995 • 112 citations

Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase.

1992 • 111 citations

Engineered Biosynthesis of Novel Polyketides: Dissection of the Catalytic Specificity of the act Ketoreductase

1994 • 109 citations

Complete nucleotide sequence of the tycA gene coding the tyrocidine synthetase 1 fromBacillus brevis

1988 • 108 citations

Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)

1995 • 105 citations

Evolution of the chalcone synthase gene family in the genus Ipomoea.

1995 • 105 citations

Biosynthesis of fatty acid and polyketide metabolites

1995 • 105 citations

Engineered Biosynthesis of Novel Polyketides: actVII and actIV Genes Encode Aromatase and Cyclase Enzymes, Respectively

1994 • 99 citations

Structural organization of the multifunctional animal fatty‐acid synthase

1991 • 99 citations

Acetyl Coenzyme A Carboxylase System of Escherichia coli

1974 • 98 citations

The protein thiotemplate mechanism of synthesis for the peptide antibiotics produced by Bacillus brevis.

1973 • 97 citations

Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase

1992 • 97 citations

Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities

1993 • 97 citations

Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase

1992 • 96 citations

Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase.

1994 • 94 citations

Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase.

1987 • 93 citations

Nucleotide sequence analysis reveals linked N-acetyl hydrolase, thioesterase, transport, and regulatory genes encoded by the bialaphos biosynthetic gene cluster of Streptomyces hygroscopicus

1991 • 93 citations

Engineered biosynthesis of a triketide lactone from an incomplete modular polyketide synthase

1994 • 91 citations

Substrate specificity of chalcone synthase from Petroselinum hortense. Formation of phloroglucinol derivatives from aliphatic substrates.

1983 • 89 citations

Three‐dimensional structure of acyl carrier protein in solution determined by nuclear magnetic resonance and the combined use of dynamical simulated annealing and distance geometry

1988 • 89 citations

Tetracenomycin F1 monooxygenase: Oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens

1993 • 88 citations

Bacterial Production of Antibiotic Polypeptides by Thiol-Linked Synthesis on Protein Templates

1981 • 88 citations

Polyketide synthesis in vitro on a modular polyketide synthase

1995 • 86 citations

Role of the D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid

1994 • 85 citations

Actinomycete Antibiotics

1962 • 85 citations

Studies on the yeast fatty acid synthetase. Subunit composition and structural organization of a large multifunctional enzyme complex.

1978 • 84 citations

Construction, expression, and characterization of a mutated animal fatty acid synthase deficient in the dehydrase function.

1993 • 84 citations

A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes

1995 • 83 citations

Physicochemical studies of the rat liver and adipose fatty acid synthetases.

1979 • 82 citations

Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase

1996 • 82 citations

Cell-free biosynthesis of new cyclosporins.

1989 • 82 citations

Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence

1994 • 81 citations

Biosynthesis of fatty acid and polyketide metabolites

1993 • 79 citations

Fatty acid biosynthesis in yeast

1978 • 79 citations

Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor

1994 • 78 citations

Detection of 4'‐phosphopantetheine at the thioester binding site for <scp>l</scp>‐valine of gramicidinS synthetase 2

1994 • 78 citations

6‐Methylsalicylic Acid Synthetase from Penicillium patulum

1976 • 77 citations

Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation/termination signals in the cDNA

1989 • 75 citations

Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum

1992 • 73 citations

Welkstoffe und Antibiotika. 7. Mitteilung. Über die Isolierung neuartiger Antibiotika aus Fusarien

1948 • 71 citations

The presence and possible role of phosphopantothenic acid in gramicidin S synthetase

1970 • 66 citations

The Streptomyces glaucescens tcmKL polyketide synthase and tcmN polyketide cyclase genes govern the size and shape of aromatic polyketides

1995 • 66 citations

N-Methyltransferase function of the multifunctional enzyme enniatin synthetase

1987 • 65 citations

Polyketide synthase acyl carrier proteins from Streptomyces: expression in Escherichia coli, purification and partial characterisation

1995 • 64 citations

Biosynthesis of polyketide metabolites

1992 • 63 citations

Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin‐producing polyketide synthase

1993 • 63 citations

Isolation of orsellinic acid synthase

1968 • 61 citations

Engineered Biosynthesis of Novel Polyketides: Analysis of tcmN Function in Tetracenomycin Biosynthesis

1995 • 60 citations

Three Conserved Glycine Residues in Valine Activation of Gramicidin S Synthetase 2 from Bacillus brevis

1995 • 57 citations

Erythromycin Biosynthesis: Kinetic Studies on a Fully Active Modular Polyketide Synthase Using Natural and Unnatural Substrates

1996 • 57 citations

VII.—The formation of orcinol and other condensation products from dehydracetic acid

1893 • 57 citations

Bacterial Expression of Catalytically Active Fragments of the Multifunctional Enzyme Enniatin Synthetase

1994 • 55 citations

On the question of half- or full-site reactivity of animal fatty acid synthetase.

1984 • 55 citations

Die Malonyl‐Bindungsstellen des Fettsäuresynthetase‐Komplexes aus Hefe

1970 • 52 citations

Epimerization of the D-Valine Portion in the Biosynthesis of Actinomycin D

1994 • 52 citations

Macrolide biosynthesis. 3. Stereochemistry of the chain-elongation steps of erythromycin biosynthesis

1986 • 51 citations

Pantetheine-Linked Peptide Intermediates in Gramicidin S and Tyrocidine Biosynthesis

1971 • 51 citations

Reaction of Yeast Fatty Acid Synthetase with Iodoacetamide

1977 • 51 citations

CRYSTALLIZATION OF A MULTIENZYME COMPLEX: FATTY ACID SYNTHETASE FROM YEAST

1969 • 50 citations

Biosynthesis of the erythromycin macrolactone and a rational approach for producing hybrid macrolides

1992 • 49 citations

Arrangement of Catalytic Sites in the Multifunctional Enzyme Enniatin Synthetase

1995 • 49 citations

Animal fatty acid synthetase. Identification of the residues comprising the novel arrangement of the beta-ketoacyl synthetase site and their role in its cold inactivation.

1982 • 48 citations

Macrolide biosynthesis—II

1983 • 48 citations

Yeast fatty acid synthase: structure to function relationship

1985 • 46 citations

The fabJ-encoded beta-ketoacyl-[acyl carrier protein] synthase IV from Escherichia coli is sensitive to cerulenin and specific for short-chain substrates.

1994 • 46 citations

ATP Binding in Peptide Synthetases: Determination of Contact Sites of the Adenine Moiety by Photoaffinity Labeling of Tyrocidine Synthetase 1 with 2-Azidoadenosine Triphosphate

1994 • 45 citations

Contribution to knowledge of the biosynthesis of cyclosporin A

1983 • 44 citations

The putative fabJ gene of Escherichia coli fatty acid synthesis is the fabF gene

1995 • 43 citations

Remarkably broad substrate specificity of a modular polyketide synthase in a cell-free system

1995 • 41 citations

The yeast fatty acid synthetase. Structure-function relationship and the role of the active cysteine-SH and pantetheine-SH.

1981 • 40 citations

Efficient Synthesis of Aromatic Polyketides in Vitro by the Actinorhodin Polyketide Synthase

1996 • 40 citations

Reaction of Yeast Fatty Acid Synthetase with Iodoacetamide

1977 • 38 citations

Yeast fatty acid synthetase: Structure—function relationship and nature of the β-ketoacyl synthetase site

1980 • 38 citations

Small-angle neutron-scattering and electron microscope studies of the chicken liver fatty acid synthase.

1987 • 38 citations

Utilization of an active serine 101—-cysteine mutant to demonstrate the proximity of the catalytic serine 101 and histidine 237 residues in thioesterase II.

1992 • 36 citations

Further Purification and Properties of Adenosine Triphosphate-dependent Phenylalanine Racemase of Bacillus brevis NAGANO*

1969 • 35 citations

Untersuchungen zur Biogenese des Erythromycins

1960 • 35 citations

Identity of Malonyl and Palmitoyl Transferase of Fatty Acid Synthetase from Yeast. 2. A Comparison of Active-Site Peptides

1979 • 34 citations

Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A. Identification of 3(R)-hydroxy-4(R)-methyl-6(E)-octenoic acid as a key intermediate by enzymatic in vitro synthesis and by in vivo labeling techniques.

1993 • 34 citations

Mechanism of the chain extension step in the biosynthesis of fatty acids

1988 • 34 citations

Effect of Single Base Substitutions at Glycine-870 Codon of Gramicidin S Synthetase 2 Gene on Proline Activation1

1993 • 34 citations

Biosynthesis of polyketides. Purification and inhibition studies of 6-methylsalicylic acid synthase

1974 • 34 citations

Structure-function relationships of the yeast fatty acid synthase: negative-stain, cryo-electron microscopy, and image analysis studies of the end views of the structure.

1992 • 33 citations

Transacylation as a chain-termination mechanism in fatty acid synthesis by mammalian fatty acid synthetase. Synthesis of butyrate and hexanoate by lactating cow mammary gland fatty acid synthetase

1980 • 32 citations

Charakterisierung der Acetyltransferase in der Fettsaäresynthetase aus Hefe

1972 • 32 citations

Mechanisms of enzyme action

1970 • 32 citations

A single change of histidine to glutamine alters the substrate preference of a stilbene synthase.

1992 • 32 citations

[25] Medium-chain fatty acyl-S-4′-phosphopantetheine-fatty acid synthase thioester hydrolase from lactating mammary gland of rat

1981 • 31 citations

The isolation of the two subunits of yeast fatty acid synthetase

1978 • 29 citations

Isolation and Structural Elucidation of Tetracenomycin F2 and Tetracenomycin F1: Early Intermediates in the Biosynthesis of Tetracenomycin C in Streptomyces glaucescens

1993 • 29 citations

Localization of the central and peripheral SH-groups on the same polypeptide chain of yeast fatty acid synthetase

1976 • 28 citations

5 Acyl Group Transfer (Acyl Carrier Protein)

1973 • 26 citations

Engineered Biosynthesis of Novel Polyketides: Regiospecific Methylation of an Unnatural Substrate by the tcmO O-Methyltransferase

1996 • 26 citations

Macrolide biosynthesis. 5. Intact incorporation of a chain-elongation intermediate into nargenicin

1988 • 25 citations

Nonstereospecific proton removal in the enzymatic formation of orsellinic acid from chiral malonate

1989 • 25 citations

Fluorescence studies of chicken liver fatty acid synthase. Segmental flexibility and distance measurements.

1986 • 24 citations

Erythromycin biosynthesis: Exploiting the catalytic versatility of the modular polyketide synthase

1996 • 24 citations

Structure of fatty acid synthetase from the harderian gland of guinea pig

1988 • 23 citations

Gramicidin S Synthetase, an Enzyme with an Unusually Large Number of Catalytic Functions

1972 • 23 citations

The cell surface receptor for immunoglobulin E. II. Properties of the purified biologically active receptor.

1979 • 23 citations

Small “Non-velocity” Redshifts in Galaxies

1972 • 22 citations

Substrate and Product Binding Sites of Yeast Fatty Acid Synthase. Stoichiometry and Binding Kinetics of Wild-Type and in vitro Mutated Enzymes

1995 • 22 citations

Investigation of the mechanism and steric course of the reaction catalyzed by 6-methylsalicylic acid synthase from Penicillium patulum using (R)-[1-13C;2-2H] and (S)-[1-13C; 2-2H]malonates

1992 • 22 citations

The arrangement and role of some of the amino acid residues in the beta-ketoacyl synthetase site of chicken liver fatty acid synthetase.

1983 • 21 citations

Reaction Mechanism of Gramicidin S Synthetase 1, Phenylalanine Racemase, of Bacillus brevis

1989 • 21 citations

Differential Activities and Intramolecular Location of Fatty Acid Synthase and 6-Methylsalicylic Acid Synthase Component Enzymes

1994 • 20 citations

Synthesis of fatty acids from malonyl-CoA and NADPH by pigeon liver fatty acid synthetase

1974 • 20 citations

The biosynthesis of tetraketides: enzymology, mechanism and molecular programming

1993 • 20 citations

Sulfhydryl Groups Related to the Catalytic Activity of Gramicidin S Synthetase 1 of Bacillus brevis1

1981 • 19 citations

Amino acid sequences of pyridoxal 5'-phosphate binding sites and fluorescence resonance energy transfer in chicken liver fatty acid synthase

1989 • 18 citations

Chapter 3 Genetics of fatty acid biosynthesis in yeast

1984 • 18 citations

Substrate and Product Binding Sites of Yeast Fatty Acid Synthase. Stoichiometry and Binding Kinetics of Wild-Type and in vitro Mutated Enzymes

1995 • 17 citations

Identity of Malonyl and Palmitoyl Transferase of Fatty Acid Synthetase from Yeast. 1. Functional Interrelationships between the Acyl Transferases

1979 • 16 citations

Hybridization studies of chicken liver fatty acid synthetase. Evidence for the participation in palmitate synthesis of cysteine and phosphopantetheine sulfhydryl groups on adjacent subunits.

1984 • 16 citations

[Effect of schizophyllan on macrophage migration inhibition test in tumor-bearing mice].

1972 • 15 citations

[38] 6-Methylsalicylic acid synthetase

1975 • 15 citations

Measurement of distance between the active serine of the thioesterase domain and the pantetheine thiol of fatty acid synthase by fluorescence resonance energy transfer.

1985 • 15 citations

The yeast fatty acid synthase. Pathway for transfer of the acetyl group from coenzyme A to the Cys-SH of the condensation site.

1990 • 15 citations

Stereospecific manipulation of hydrogen atoms with opposite absolute orientations during the biosynthesis of the polyketide 6-methylsalicylic acid from chiral malonates in Penicillium patulum

1990 • 7 citations

The cloning and overexpression of E coli acyl carrier protein (ACP)

1993 • 5 citations

Mutant Genes of Gramicidin S Synthetase 1 Defective in Phenylalanine Racemization Have the Same Sequence as the Wild Gene

1994 • 5 citations

Preliminary X-ray Diffraction Analysis of β-Ketoacyl-[Acyl Carrier Protein] Synthase I from Escherichia coli

1994 • 3 citations

The development and application of a novel chromophoric substrate for investigation of the mechanism of yeast fatty acid synthase

1985 • 3 citations

Modeling spray/puddle dissolution processes for deep-ultraviolet acid-hardened resists

1993 • 2 citations

Deleted Work

1955 • 0 citations