Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Experiments in molecular genetics

1972 • 28,260 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Studies on transformation of Escherichia coli with plasmids

1983 • 11,179 citations

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1984 • 4,231 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

Rapid and efficient cosmid cloning

1981 • 1,897 citations

Lambda replacement vectors carrying polylinker sequences

1983 • 1,809 citations

The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences

1984 • 820 citations

Factors affecting the isolation of CCC DNA from Streptomyces lividans and Escherichia coli

1984 • 745 citations

Production of ‘hybrid’ antibiotics by genetic engineering

1985 • 364 citations

pUR222, a vector for cloning and rapid chemical sequencing of DNA

1981 • 267 citations

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

1989 • 250 citations

The Streptomyces plasmid SCP2∗: its functional analysis and development into useful cloning vectors

1985 • 208 citations

Genetics of Actinorhodin Biosynthesis by Streptomyces coelicolor A3(2)

1979 • 197 citations

Physical and genetic characterisation of the gene cluster for the antibiotic actinorhodin inStreptomyces coelicolor A3(2)

1986 • 187 citations

Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor

1988 • 178 citations

Acetoacetyl-acyl carrier protein synthase, a potential regulator of fatty acid biosynthesis in bacteria.

1987 • 172 citations

Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

1987 • 164 citations

On the Structure of Fatty Acid Synthetase of Yeast

1980 • 164 citations

β-ketoacyl-ACP synthase I of Escherichia coli: Nucleotide sequence of thefabB gene and identification of the cerulenin binding residue

1988 • 151 citations

The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains

1986 • 126 citations

Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence.

1988 • 121 citations

The significance of protein sequence similarities

1988 • 100 citations

Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase.

1987 • 93 citations

Substrate specificity of chalcone synthase from Petroselinum hortense. Formation of phloroglucinol derivatives from aliphatic substrates.

1983 • 89 citations

Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor.

1987 • 79 citations

New derivatives of the Streptomyces temperate phage φC31 useful for the cloning and functional analysis of Streptomyces DNA

1985 • 71 citations

Derived amino acid sequence and identification of active site residues of Escherichia coli beta-hydroxydecanoyl thioester dehydrase.

1988 • 71 citations

Organization and regulation of genes encoding biosynthetic enzymes in Bacillus subtilis.

1988 • 63 citations

A small, discrete acyl carrier protein is involved in de novo fatty acid biosynthesis in Streptomyces erythraeus

1987 • 28 citations

Macrolide antibiotics

2015 • 15 citations

Role of escherichia coli β-ketoacyl-ACP synthase I in unsaturated fatty acid synthesis

1988 • 12 citations

The Relationship between Structure and Function for and the Regulation of the Enzymes of Fatty Acid Synthesis^a

1986 • 11 citations

Oligonucleotide probes for bacterial acylcarrier protein genes

1985 • 4 citations