Engineered Biosynthesis of Novel Polyketides

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

1991 • 883 citations

Fatty acid synthase, a proficient multifunctional enzyme

1989 • 801 citations

MOLECULAR GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY ACID BIOSYNTHESIS

1990 • 674 citations

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

1990 • 611 citations

Fatty Acid Biosynthesis Redirected to Medium Chains in Transgenic Oilseed Plants

1992 • 427 citations

POLYKETIDE SYNTHESIS: Prospects for Hybrid Antibiotics

1993 • 369 citations

Genetic manipulation of Streptomyces

1985 • 361 citations

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

1984 • 358 citations

The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of streptomyces

1991 • 357 citations

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

1989 • 250 citations

Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.

1992 • 229 citations

Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

1989 • 226 citations

A vector system with temperature-sensitive replication for gene disruption and mutational cloning in streptomycetes

1989 • 223 citations

The Streptomyces plasmid SCP2∗: its functional analysis and development into useful cloning vectors

1985 • 208 citations

Stationary‐phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated

1993 • 201 citations

Physical and genetic characterisation of the gene cluster for the antibiotic actinorhodin inStreptomyces coelicolor A3(2)

1986 • 187 citations

Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

1992 • 182 citations

Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor

1988 • 178 citations

Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

1987 • 164 citations

Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions

1990 • 157 citations

Organisation and functions of the actV A region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor

1991 • 100 citations

Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase

1992 • 97 citations

Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities

1993 • 97 citations

[21] Genetic manipulation of Streptomyces: Integrating vectors and gene replacement

1991 • 88 citations

Polyketide synthase com plexes: their structure and function in antibiotic biosynthesis

1991 • 82 citations

Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor.

1987 • 79 citations

Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: role for the acyl carrier protein

1992 • 73 citations

Mutactin, a novel polyketide from Streptomyces coelicolor. Structure and biosynthetic relationship to actinorhodin

1990 • 63 citations

Anthracycline metabolites of tetracenomycin C-nonproducing Streptomyces glaucescens mutants

1986 • 49 citations

Functional replacement of genes for individual polyketide synthase components in Streptomyces coelicolor A3(2) by heterologous genes from a different polyketide pathway

1992 • 43 citations

Molecular genetic analysis reveals a putative bifunctional polyketide cyclase/dehydrase gene from Streptomycea coelicolor and Streptomyces violoceoruber, and a cyclase/O-methyltransferase from Streptomyces glaucescens.

1991 • 40 citations

Chemistry of the Coccoidea. VIII. Synthesis of the ancient dyestuff kermesic acid and of related anthraquinones

1981 • 31 citations

Genetic Regulation of Secondary Metabolic Pathways in Streptomyces

2007 • 21 citations

Ein α‐Methylanthrachinon aus Streptomyceten

1989 • 20 citations

Molecular Genetics and Biochemistry of Type II Polyketide Synthases from the Perspective of Tetracenomycin C Biosynthesis in Streptomyces glaucescens.

1992 • 4 citations