A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A Broad Host Range Mobilization System for In Vivo Genetic Engineering: Transposon Mutagenesis in Gram Negative Bacteria

1983 • 7,336 citations

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.

1992 • 4,683 citations

Construction and characterization of new cloning vehicle. II. A multipurpose cloning system

1977 • 3,829 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

1991 • 883 citations

A small cosmid for efficient cloning of large DNA fragments

1980 • 829 citations

Lambdoid phages that simplify the recovery of in vitro recombinants

1977 • 779 citations

MOLECULAR GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY ACID BIOSYNTHESIS

1990 • 674 citations

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

1990 • 611 citations

Genetics and Molecular Biology of Industrial Microorganisms

1989 • 319 citations

The multifunctional 6‐methylsalicylic acid synthase gene of Penicillium patulum

1990 • 301 citations

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

1989 • 250 citations

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

1992 • 238 citations

Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

1989 • 226 citations

Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics

1990 • 184 citations

Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

1987 • 164 citations

Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.

1989 • 159 citations

The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (myxobacteria). I. Soraphen A1.ALPHA.: Fermentation, isolation, biological properties.

1994 • 152 citations

β-ketoacyl-ACP synthase I of Escherichia coli: Nucleotide sequence of thefabB gene and identification of the cerulenin binding residue

1988 • 151 citations

Antibiotics from Gliding Bacteria, LIV. Isolation and Structure Elucidation of Soraphen A_1α, a Novel Antifungal Macrolide from Sorangium cellulosum

1993 • 113 citations

Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A

1994 • 105 citations

Myxobacteria: a source of new antibiotics

1988 • 91 citations

Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence

1994 • 81 citations

Acquisition by Escherichia coli of plasmid-borne β-lactamases normally confined to Pseudomonas spp

1979 • 68 citations

Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus

1994 • 58 citations

Genes for Polyketide Secondary Metabolic Pathways in Microorganisms and Plants

2007 • 54 citations

Structure of myxovirescin A, a new macrocylic antibiotic from gliding bacteria

1982 • 50 citations

Characterisation of actI-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis

1992 • 40 citations

Cloning of large DNA fragments, which hybridize with actinorhodin biosynthesis genes, from kalafungin and nanaomycin a methyl ester producers and identification of genes for kalafungin biosynthesis of the kalafungin producer.

1991 • 39 citations

Transfer of mobilizable plasmids to Sorangium cellosum and evidence for their integration into the chromosome

1992 • 37 citations

Mutation and mapping of genes involved in production of the antibiotic TA in Myxococcus xanthus

1992 • 30 citations