Biosynthesis of the erythromycin macrolactone and a rational approach for producing hybrid macrolides

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

1991 • 883 citations

MOLECULAR GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY ACID BIOSYNTHESIS

1990 • 674 citations

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

1990 • 611 citations

Cloning and analysis of the promoter region of the erythromycin-resistance gene (ermE) of Streptomyces erythraeus

1986 • 347 citations

The multifunctional 6‐methylsalicylic acid synthase gene of Penicillium patulum

1990 • 301 citations

Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)

1989 • 288 citations

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

1992 • 238 citations

Biosynthesis of Peptide Antibiotics

1987 • 172 citations

Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

1987 • 164 citations

Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.

1989 • 159 citations

Macrolide biosynthesis. 4. Intact incorporation of a chain-elongation intermediate into erythromycin.

1987 • 144 citations

The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains

1986 • 126 citations

N-methyl transferase of Streptomyces erythraeus that confers resistance to the macrolidelincosamide-streptogramin B antibiotics: amino acid sequence and its homology to cognate R-factor enzymes from pathogenic bacilli and cocci

1985 • 110 citations

β-Hydroxydecanoyl Thioester Dehydrase

1969 • 103 citations

Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea

1990 • 101 citations

Structural organization of the multifunctional animal fatty‐acid synthase

1991 • 99 citations

Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase.

1987 • 93 citations

Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis

1989 • 82 citations

Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation/termination signals in the cDNA

1989 • 75 citations

Derived amino acid sequence and identification of active site residues of Escherichia coli beta-hydroxydecanoyl thioester dehydrase.

1988 • 71 citations

Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid

1990 • 68 citations

Molecular cloning and sequencing of chicken liver fatty acid synthase cDNA.

1989 • 64 citations

Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli

1990 • 64 citations

Characterization of an insertion sequence (IS891) of novel structure from the cyanobacterium Anabaena sp. strain M-131

1989 • 53 citations

Molecular cloning and sequencing of DNA complementary to chicken liver fatty acid synthase mRNA.

1988 • 51 citations

Identification of a gene required for the terminal step in erythromycin A biosynthesis in Saccharopolyspora erythraea (Streptomyces erythreus)

1989 • 49 citations

15 β-Hydroxydecanoyl Thioester Dehydrase

1971 • 45 citations

Isolation of proposed intermediates in the biosynthesis of mycinamicins

1988 • 28 citations

Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin

1990 • 24 citations