Biosynthesis of polyketide metabolites

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

1991 • 883 citations

Fatty acid synthase, a proficient multifunctional enzyme

1989 • 801 citations

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

1990 • 611 citations

ORGANIZATION AND EXPRESSION OF GENES INVOLVED IN THE BIOSYNTHESIS OF ANTIBIOTICS AND OTHER SECONDARY METABOLITES

1989 • 327 citations

Esperamicins, a novel class of potent antitumor antibiotics. 3. Structures of esperamicins A1, A2, and A1b

1987 • 311 citations

The multifunctional 6‐methylsalicylic acid synthase gene of Penicillium patulum

1990 • 301 citations

On the mechanism of prostacyclin and thromboxane A2 biosynthesis

1989 • 287 citations

Genetics of Actinorhodin Biosynthesis by Streptomyces coelicolor A3(2)

1979 • 197 citations

Biosynthese von 6‐Methylsalicylsäure

1970 • 183 citations

Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor

1988 • 178 citations

The role of cysteines in polyketide synthases. Site-directed mutagenesis of resveratrol and chalcone synthases, two key enzymes in different plant-specific pathways

1991 • 175 citations

Acetoacetyl-acyl carrier protein synthase, a potential regulator of fatty acid biosynthesis in bacteria.

1987 • 172 citations

Novel avermectins produced by mutational biosynthesis.

1991 • 169 citations

Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions

1990 • 157 citations

Macrolide biosynthesis. 4. Intact incorporation of a chain-elongation intermediate into erythromycin.

1987 • 144 citations

Asymmetric allylboration with B-allyl-2-(trimethylsilyl)borolane

1989 • 133 citations

Biosynthetic studies of brevetoxins, potent neurotoxins produced by the dinoflagellate Gymnodinium breve

1989 • 133 citations

Metabolic products of microorganisms. 234 Urdamycins, new angucycline antibiotics from Streptomyces fradiae. I Isolation, characterization and biological properties.

1986 • 128 citations

A Cerulenin Insensitive Short Chain 3-Ketoacyl-Acyl Carrier Protein Synthase in Spinacia oleracea Leaves

1989 • 127 citations

Calicheamicins, a novel family of antitumor antibiotics. 3. Isolation, purification and characterization of calicheamicins .BETA.1Br, .GAMMA.1Br, .ALPHA.2I, .ALPHA.3I, .BETA.1I, .GAMMA.1I and .DELTA.1I.

1989 • 126 citations

Macrolide biosynthesis. Tylactone formation involves the processive addition of three carbon units

1987 • 118 citations

Biosynthetic origins and assignments of carbon 13 NMR peaks of brevetoxin B

1986 • 108 citations

Three-dimensional structure of acyl carrier protein determined by NMR pseudoenergy and distance geometry calculations

1988 • 104 citations

Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase.

1988 • 102 citations

Biosynthesis of brevetoxins. Evidence for the mixed origin of the backbone carbon chain and possible involvement of dicarboxylic acids

1987 • 99 citations

Phospholipid studies of marine organisms. Part 25. Sponge phospholipids

1991 • 97 citations

Structure of preussomerin A: an unusual new antifungal metabolite from the coprophilous fungus Preussia isomera

1990 • 92 citations

Cloning and expression of daunorubicin biosynthesis genes from Streptomyces peucetius and S. peucetius subsp. caesius

1990 • 77 citations

Biosynthesis of NCS Chrom A, the chromophore of the antitumor antibiotic neocarzinostatin

1989 • 72 citations

Biosyntheses of antibiotic A26771B by Penicillium turbatum and dehydrocurvularin by Alternaria cinerariae: comparison of stereochemistry of polyketide and fatty acid enoyl thiol ester reductases

1989 • 71 citations

Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity.

1991 • 68 citations

Polyether biosynthesis. 2. Origin of the oxygen atoms of monensin A

1982 • 68 citations

Structure and mechanism of action of a multifunctional enzyme: fatty acid synthase

1990 • 65 citations

Experiments and speculations on the role of oxidative cyclization chemistry in natural product biosynthesis

1991 • 65 citations

Isolation and structure of constanolactones A and B, new cyclopropyl hydroxy-eicosanoids from the temperate red alga constantinea simplex

1990 • 64 citations

Biosynthesis of methyl branched hydrocarbons of the German cockroach Blattella germanica (L.) (orthoptera, blattellidae)

1990 • 63 citations

Mutactin, a novel polyketide from Streptomyces coelicolor. Structure and biosynthetic relationship to actinorhodin

1990 • 63 citations

Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. I. Production, isolation and physico-chemical and biological properties.

1991 • 62 citations

Fluoro-fatty Acids in the Seeds of Dichapetalum toxicarium

1964 • 62 citations

An acyl‐carrier‐protein – thioesterase domain from the 6‐deoxyerythronolide B synthase of Saccharopolyspora erythraea

1991 • 61 citations

The structure of tautomycin, a dialkylmaleic anhydride antibiotic.

1990 • 60 citations

The baconipyrones. Novel polypropionates from the pulmonate Siphonaria baconi

1989 • 57 citations

Comparison of fatty acid and polyketide biosynthesis: stereochemistry of cladosporin and oleic acid formation in Cladosporium cladosporioides

1989 • 57 citations

Intact incorporation of acetate-derived di- and tetraketides during biosynthesis of dehydrocurvularin, a macrolide phytotoxin from Alternaria cinerariae

1990 • 57 citations

New antibiotic produced by Micromonospora globosa.

1990 • 55 citations

BIOSYNTHESIS OF LASALOCID. II

1974 • 55 citations

Cloning, characterization, and high-level expression in Escherichia coli of the Saccharopolyspora erythraea gene encoding an acyl carrier protein potentially involved in fatty acid biosynthesis

1991 • 54 citations

Formation of a cyclopropyl eicosanoid via an allene oxide in the coral Plexaura homomalla: implications for the biosynthesis of 5,6-trans-prostaglandin A2

1989 • 49 citations

Characterization of recombinant thioesterase and acyl carrier protein domains of chicken fatty acid synthase expressed in Escherichia coli

1989 • 49 citations

Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. II. Structure elucidation of purpactins A, B and C.

1991 • 47 citations

Pectinatone, a new antibiotic from the mollusc siphonaria pectinata

1983 • 44 citations

Total synthesis of (-)-denticulatins A and B: marine polypropionates from Siphonaria denticulata

1990 • 44 citations

Urdamycins, new angucycline antibiotics from Streptomyces fradiae. IV. Biosynthetic studies of urdamycins A-D.

1989 • 44 citations

Obionin A: A new polyketide metabolite from the marine fungus leptosphaeria obiones

1989 • 42 citations

Deoxygenation of phenolic natural products. Enzymic conversion of emodin to chrysophanol

1988 • 42 citations

The structure of tautomycetin, a dialkylmaleic anhydride antibiotic.

1990 • 39 citations

Urdamycins, new angucycline antibiotics from Streptomyces fradiae. VI. Structure elucidation and biosynthetic investigations on urdamycin H.

1989 • 39 citations

The short chain condensing enzyme has a widespread occurrence in the fatty acid synthetases from higher plants

1990 • 39 citations

Vallartanones A and B, polypropionate metabolites of Siphonaria maura from Mexico

1989 • 38 citations

Synthesis of Putative Intermediates on the Monensin Biosynthetic Pathway and Incorporation Experiments with the Monensin‐Producing Organism

1990 • 38 citations

New metabolites from the marine mollusc siphonaria grisea

1990 • 38 citations

Mechanism of activation of the antitumor antibiotic neocarzinostatin by mercaptan and sodium borohydride.

1989 • 37 citations

Prostaglandin 1,15-lactones of the F series from the nudibranch mollusk Tethys fimbria

1991 • 35 citations

High molecular weight polyacetylenes from Petrosia ficiformis: Further structural analysis and biological activity

1989 • 35 citations

Efficient Stereoselective Total Synthesis of Denticulatins A and B

1991 • 34 citations

Partitioning of tetrahydro- and dihydrobisfuran formation in aflatoxin biosynthesis defined by cell-free and direct incorporation experiments

1989 • 34 citations

Derailment product in NADPH‐dependent synthesis of a dihydroisocoumarin 6‐hydroxymellein by elicitor‐treated carrot cell extracts

1989 • 34 citations

Naturally occurring prostaglandin-1,15-lactones

1989 • 32 citations

Biogenesis of chromomycin A3 by Streptomyces griseus.

1990 • 30 citations

Identification of threo-ig-fluoro.9,10-Dihydroxystearic acid:a novel cofluorinated fatty acid from dichapetalum toxicarium seeds.

1990 • 29 citations

Fatty acid incorporation in the biosynthesis of anacardic acids of geraniums

1990 • 27 citations

Gas chromatographic-mass spectroscopic identification of protaglandin F2? in floweringKalanchoe blossfeldiana v. Poelln.

1982 • 25 citations

Macrolide biosynthesis. 5. Intact incorporation of a chain-elongation intermediate into nargenicin

1988 • 25 citations

Nonstereospecific proton removal in the enzymatic formation of orsellinic acid from chiral malonate

1989 • 25 citations

The timing of aromatic deoxygenation in aflatoxin biosynthesis

1989 • 25 citations

Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin

1990 • 24 citations

Unusual Pattern of Fatty Acid Biosynthesis

1989 • 24 citations

Separation and identification of prostaglandin A₁ in onion

1980 • 23 citations

Biosynthesis of kalafungin in Streptomyces tanashiensis.

1990 • 23 citations

Biosynthetic origin of the carbon skeleton and oxygen atoms of the LL-F28249.ALPHA., apoent antiparasitic macrolide.

1989 • 22 citations

The Bioconversion of (3RS,E)‐ and (3RS,Z)‐Nerolidol into Oxygenated Products by Streptomyces cinnamonensis. Possible Implications for the Biosynthesis of the Polyether Antibiotic Monensin A??

1990 • 21 citations

Biosynthesis of the streptovaricins: 3-Amino-5-hydroxybenzoic acid as a precursor to the meta-C7N unit.

1991 • 20 citations

Macrolide (cucujolide) biosynthesis in the rusty grain beetle, Cryptolestes ferrugineusI

1990 • 20 citations

Biosynthesis of benanomicins.

1989 • 19 citations

The carboxyl-terminal region of thioesterase II participates in the interaction with fatty acid synthase. Use of electrospray ionization mass spectrometry to identify a carboxyl-terminally truncated form of the enzyme.

1990 • 18 citations

Structure and biosynthesis of a new antifungal antibiotic, phthoramycin.

1989 • 18 citations

Selection of a specifically blocked mutant of. Streptomyces cinnamonensis: Isolation and synthesis of 26-deoxymonensin A.

1989 • 16 citations

Biosynthesis of the terpenoidic polyketide fusalanipyrone*

1990 • 16 citations

Novel macrolides from Micromonospora rosaria.

1990 • 14 citations

Arachidonic acid and prostaglandins in buds of Populus balsamifera

1990 • 13 citations

Biosynthesis of the antibiotic okilactomycin.

1989 • 11 citations

Biosynthesis and 13C NMR assignment of cytovaricin, a neutral macrolide antibiotic.

1989 • 11 citations

The biosynthesis of chromomycin-A3

1988 • 10 citations

新トリアゾール系抗真菌剤Itraconazoleの深在性真菌症患者分離株に対する in vitro 抗真菌活性

1991 • 1 citations